Results 71 to 80 of about 24,391 (241)

Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration [PDF]

, 2017
The loss of cone photoreceptors that mediate daylight vision represents a leading cause of blindness, for which cell replacement by transplantation offers a promising treatment strategy.
Naeem, A, Kloc, M., Decembrini, S, Sampson, R.D., Goh, D, Jonikas, M, Maswood, RN, Maswood, R.N., West, E.L., Sowden, J.C., Smith, A.J., Duran, Y, Sowden, JC, Gonzalez-Cordero, A, Arsenijevic, Y., Jonikas, M., Kruczek, K, Georgiadis, A., Pearson, R.A., Arsenijevic, Y, Gonzalez-Cordero, A., Sampson, RD, Ali, R.R., Kloc, M, Goh, D., Ali, RR, Blackford, SJI, Georgiadis, A, Pearson, RA, Duran, Y., Naeem, A., West, EL, Kruczek, K., Decembrini, S., Smith, AJ   +34 more
core   +1 more source

Cellular and Molecular Determinants of Retinal Cell Fate

, 2022
The vertebrate retina is regarded as a simple part of the central nervous system (CNS) and thus amenable to investigations of the determinants of cell fate.
Godinho, Leanne, Petridou, Eleni
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials

Journal of Tissue Engineering, 2018
Strategies to replace retinal photoreceptors lost to damage or disease rely upon the migration of replacement cells transplanted into sub-retinal spaces.
Ankush Thakur, Shawn Mishra, Juan Pena, Jing Zhou, Stephen Redenti, Robert Majeska, Maribel Vazquez   +6 more
doaj   +1 more source

Sprouty2 regulates positioning of retinal progenitors through suppressing the Ras/Raf/MAPK pathway

Scientific Reports, 2020
Sproutys are negative regulators of the Ras/Raf/MAPK signaling pathway and involved in regulation of organogenesis, differentiation, cell migration and proliferation.
Jian Sun, Jaeho Yoon, Moonsup Lee, Yoo-Seok Hwang, Ira O. Daar   +4 more
doaj   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells

Cell, 2001
Cell 105(1), 43-55 (2001).
Marquardt, Till, Ashery-Padan, Ruth, Andrejewski, Nicole, Scardigli, Raffaella, Guillemot, Francois, Gruss, Peter   +5 more
openaire   +3 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

RNA fusion in human retinal development

eLife
Chimeric RNAs have been found in both cancerous and healthy human cells. They have regulatory effects on human stem/progenitor cell differentiation, stemness maintenance, and central nervous system development.
Wen Wang, Xiao Zhang, Ning Zhao, Ze-Hua Xu, Kangxin Jin, Zi-Bing Jin   +5 more
doaj   +1 more source

Notch Signaling-Induced Oscillatory Gene Expression May Drive Neurogenesis in the Developing Retina

Frontiers in Molecular Neuroscience, 2019
After integrating classic and cutting-edge research, we proposed a unified model that attempts to explain the key steps of mammalian retinal neurogenesis.
Dmitry Ivanov, Dmitry Ivanov
doaj   +1 more source