Results 71 to 80 of about 5,449,684 (261)

Identification of a modular super-enhancer in murine retinal development

Nature Communications, 2022
Super-enhancers are regions of genomic DNA comprised of multiple putative enhancers that contribute to dynamic gene expression patterns during development.
Victoria Honnell, Jackie L. Norrie, Anand G. Patel, Cody Ramirez, Jiakun Zhang, Yu-Hsuan Lai, Shibiao Wan, Michael A. Dyer   +7 more
doaj   +1 more source

Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia [PDF]

, 2006
Background— Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of chemoattractant factors such as stromal cell–derived factor 1 and vascular endothelial growth ...
Dimmeler, S, Aicher, A, Heeschen, C, Sasaki, K, Urbich, C, Zeiher, AM   +5 more
core  

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Reprogramming of Adult Retinal Müller Glial Cells into Human-Induced Pluripotent Stem Cells as an Efficient Source of Retinal Cells

Stem Cells International, 2019
The reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) has broad applications in regenerative medicine. The generation of self-organized retinal structures from these iPSCs offers the opportunity to study retinal development ...
Amélie Slembrouck-Brec, Amélie Rodrigues, Oriane Rabesandratana, Giuliana Gagliardi, Céline Nanteau, Stéphane Fouquet, Gilles Thuret, Sacha Reichman, Gael Orieux, Olivier Goureau   +9 more
doaj   +1 more source

Supplementary_Data - In Situ Cross-linking Hydrogel as a Vehicle for Retinal Progenitor Cell Transplantation

, 2019
Supplementary_Data for In Situ Cross-linking Hydrogel as a Vehicle for Retinal Progenitor Cell Transplantation by Jeayoung Park, Petr Baranov, Aybike Aydin, Hany Abdelgawad, Deepti Singh, Wanting Niu, Motoichi Kurisawa, Myron Spector, and Michael J ...
Hany Abdelgawad (6527189), Myron Spector (2543191), Aybike Aydin (6527186), Wanting Niu (6527195), Jeayoung Park (6527183), Michael J. Young (223106), Petr Baranov (5532329), Motoichi Kurisawa (1532425), Deepti Singh (6527192)   +8 more
core   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish.

PLoS ONE, 2014
The precise regulation of numbers and types of neurons through control of cell cycle exit and terminal differentiation is an essential aspect of neurogenesis. The Hippo signaling pathway has recently been identified as playing a crucial role in promoting
Yoichi Asaoka, Shoji Hata, Misako Namae, Makoto Furutani-Seiki, Hiroshi Nishina   +4 more
doaj   +1 more source

Trk C Signaling Is Required for Retinal Progenitor Cell Proliferation

, 2000
Although neurotrophin actions in the survival of specific retinal cell types have been identified, the biological functions for neurotrophin-3 (NT-3) in early retinal development remain unclear.
Evangeline Shih, Janet R. Sparrow, Takashi Mikawa, Barbara L. Hempstead, Indranil Das, Michelle I. Lin   +5 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Expression status transition of NOTCH1 accompanies chromatin remodeling in human early retinal progenitor cells [version 6; peer review: 1 approved, 3 approved with reservations]

F1000Research
Background Notch signaling, especially via the Notch1 receptor, supports normal eye development by maintaining the retinal progenitor cell state before differentiation, although the regulatory mechanism behind fine-tuned Notch1 expression remains unclear.
Masaharu Yoshihara, Satoru Takahashi, Takahiro Nakayama, Sakurako Kobayashi, Yoshitoku Watabe   +4 more
doaj   +1 more source