Results 81 to 90 of about 24,391 (241)

Trk C Signaling Is Required for Retinal Progenitor Cell Proliferation

, 2000
Although neurotrophin actions in the survival of specific retinal cell types have been identified, the biological functions for neurotrophin-3 (NT-3) in early retinal development remain unclear.
Evangeline Shih, Janet R. Sparrow, Takashi Mikawa, Barbara L. Hempstead, Indranil Das, Michelle I. Lin   +5 more
core   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Advances in Retinal Stem Cell Biology

Journal of Ophthalmic & Vision Research, 2013
Tremendous progress has been made in recent years to generate retinal cells from pluripotent cell sources. These advances provide hope for those suffering from blindness due to lost retinal cells.
Andrea S Viczian
doaj  

Characterisation of immortalised human foetal retinal progenitor cell lines [PDF]

, 2008
Inherited retinal dystrophies and age-related macular degeneration (AMD) are leading causes of blindness. Current treatments only slow disease progression in a minority of patients, therefore it is important to develop new treatments that can regenerate ...
Hasan, S.M.
core  

Retinal Endothelial Cell Apoptosis Stimulates Recruitment of Endothelial Progenitor Cells [PDF]

Investigative Opthalmology & Visual Science, 2009
Bone marrow-derived endothelial progenitor cells (EPCs) contribute to vascular repair although it is uncertain how local endothelial cell apoptosis influences their reparative function. This study was conducted to determine how the presence of apoptotic bodies at sites of endothelial damage may influence participation of EPCs in retinal microvascular ...
Bhatwadekar, Ashay, Glenn, Josephine, Curtis, Timothy, Grant, M.B., Stitt, Alan, Gardiner, Tom   +5 more
openaire   +3 more sources

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Bankable human iPSC-derived retinal progenitors represent a valuable source of multipotent cells

Communications Biology, 2023
Retinal progenitor cells (RPCs) are the source of all retinal cell types during retinogenesis. Until now, the isolation and expansion of RPCs has been at the expense of their multipotency.
Sandy Gozlan, Vivien Batoumeni, Tara Fournier, Céline Nanteau, Anais Potey, Marilou Clémençon, Gaël Orieux, José-Alain Sahel, Olivier Goureau, Jérôme E. Roger, Sacha Reichman   +10 more
doaj   +1 more source

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Next-Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS. [PDF]

Cell Prolif
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Wang Y, Li J, Mao X, Wang W, Li Y, Hu X, Zhong J, Zhao F, Wang L.   +8 more
europepmc   +2 more sources