Results 81 to 90 of about 5,449,684 (261)

Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials

Journal of Tissue Engineering, 2018
Strategies to replace retinal photoreceptors lost to damage or disease rely upon the migration of replacement cells transplanted into sub-retinal spaces.
Ankush Thakur, Shawn Mishra, Juan Pena, Jing Zhou, Stephen Redenti, Robert Majeska, Maribel Vazquez   +6 more
doaj   +1 more source

Sprouty2 regulates positioning of retinal progenitors through suppressing the Ras/Raf/MAPK pathway

Scientific Reports, 2020
Sproutys are negative regulators of the Ras/Raf/MAPK signaling pathway and involved in regulation of organogenesis, differentiation, cell migration and proliferation.
Jian Sun, Jaeho Yoon, Moonsup Lee, Yoo-Seok Hwang, Ira O. Daar   +4 more
doaj   +1 more source

A comparative study of the potential for human retinal pigment epithelium utilising an embryonic chick model of the phenomenon [PDF]

, 2014
The retinal pigment epithelial (RPE) cells of several species, including: chicken, rat, mouse and newt, have been observed to undergo a phenomenon known as transdifferentiation.
Smart, MJK
core  

KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons

Cytoskeleton, EarlyView.
ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung, J. Sidhu, A. Hsieh, Y. Ma, J. Liu, M. A. Silverman   +5 more
wiley   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Advances in Retinal Stem Cell Biology

Journal of Ophthalmic & Vision Research, 2013
Tremendous progress has been made in recent years to generate retinal cells from pluripotent cell sources. These advances provide hope for those suffering from blindness due to lost retinal cells.
Andrea S Viczian
doaj  

RNA fusion in human retinal development

eLife
Chimeric RNAs have been found in both cancerous and healthy human cells. They have regulatory effects on human stem/progenitor cell differentiation, stemness maintenance, and central nervous system development.
Wen Wang, Xiao Zhang, Ning Zhao, Ze-Hua Xu, Kangxin Jin, Zi-Bing Jin   +5 more
doaj   +1 more source

Notch Signaling-Induced Oscillatory Gene Expression May Drive Neurogenesis in the Developing Retina

Frontiers in Molecular Neuroscience, 2019
After integrating classic and cutting-edge research, we proposed a unified model that attempts to explain the key steps of mammalian retinal neurogenesis.
Dmitry Ivanov, Dmitry Ivanov
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Expression status transition of NOTCH1 accompanies chromatin remodeling in human early retinal progenitor cells [version 5; peer review: 1 approved, 3 approved with reservations]

F1000Research
Background Notch signaling, especially via the Notch1 receptor, is involved in normal eye development by maintaining retinal progenitor cell state before their differentiation, although the regulatory mechanism of fine-tuned Notch1 expression is unclear.
Masaharu Yoshihara, Satoru Takahashi, Takahiro Nakayama, Sakurako Kobayashi, Yoshitoku Watabe   +4 more
doaj   +1 more source