Results 61 to 70 of about 48,539 (287)

Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish. [PDF]

, 2016
Maintaining neurogenesis in growing tissues requires a tight balance between progenitor cell proliferation and differentiation. In the zebrafish retina, neuronal differentiation proceeds in two stages with embryonic retinal progenitor cells (RPCs) of the
Cavodeassi, F, Cerveny, KL, Gestri, G, Givens, M, Hawkins, TA, Horner, W, Krasnow, AM, Lamb, DB, Lawrence, LM, Schwarz, QP, Stickney, HL, Tafessu, A, Valdivia, LE, Vleeshouwer-Neumann, TS, Wierzbicki, C, Williams, AM, Wilson, SW, Young, RM   +17 more
core   +4 more sources

Intravitreal Administration of Human Bone Marrow CD34+ Stem Cells in a Murine Model of Retinal Degeneration. [PDF]

, 2016
PurposeIntravitreal murine lineage-negative bone marrow (BM) hematopoietic cells slow down retinal degeneration. Because human BM CD34+ hematopoietic cells are not precisely comparable to murine cells, this study examined the effect of intravitreal human
Annett, Geralyn, Cary, Whitney, Moisseiev, Elad, Motta, Monica, Murphy, Christopher J, Nolta, Jan A, Oltjen, Sharon, Park, Susanna S, Smit-McBride, Zeljka, Zawadzki, Robert J, Zhang, Pengfei   +10 more
core   +2 more sources

Retinal progenitor cells (jCell) for retinitis pigmentosa

Frontiers in Cellular Neuroscience
ObjectiveTo assess the safety and tolerability of intravitreal injection of human retinal progenitor cells (RPCs) at multiple dose levels in adults with non-syndromic retinitis pigmentosa (RP).DesignA prospective, multicenter, open-label, single-arm, Phase I/IIa safety study of RPCs in adults with RP (n = 28). Two patient cohorts were studied: Cohort 1:
Yang, Jing, Kuppermann, Baruch D, Liao, David, Mehta, Mitul C, Hsiang, Chinhui, Menges, Steven, Boyer, David S, Klassen, Henry   +7 more
openaire   +3 more sources

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]

, 2015
PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David, Arana, Eloisa, Buitrago, Emiliano, Chantada, Guillermo Luis, Croxatto, Juan Oscar, del Sole, Maria Jose, Djaballah, Hakim, Francis, Jasmine, Laurent, Viviana Eunice, Mena, Hebe Agustina, Negrotto, Soledad, Schaiquevich, Paula Susana, Sgroi, Mariana, Winter, Ursula Andrea   +13 more
core   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development. [PDF]

PLoS ONE, 2016
ADAM10 and ADAM17 are two closely related members of the ADAM (a disintegrin and metalloprotease) family of membrane-bound sheddases, which proteolytically cleave surface membrane proteins.
Joseph A Toonen, Adam Ronchetti, D J Sidjanin   +2 more
doaj   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants. [PDF]

Glia
Zebrafish pde6c mutants undergo photoreceptor degeneration from 5 dpf, but rods regenerate from 4 wpf. scRNA‐seq of retinal microglia reveals dynamic change of states between 5 dpf and 4 wpf. Two states emerge specifically during regeneration. ABSTRACT Microglia, brain‐resident immune cells, maintain brain homeostasis.
Ravishankar D, Takeuchi Y, Masai I.
europepmc   +2 more sources

Single-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis. [PDF]

, 2019
The development of the mammalian retina is a complicated process involving the generation of distinct types of neurons from retinal progenitor cells (RPCs) in a spatiotemporal-specific manner.
An, Qin, Fan, Guoping, Hu, Youjin, Liu, Qinghuai, Mao, Xiying, Wang, Jinmei, Xi, Huiyu, Yang, Xian-Jie, Yuan, Songtao, Zhang, Xiangmei   +9 more
core  

CD133adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF) [PDF]

, 2009
Background CD133 is a cell surface marker of haematopoietic stem and progenitor cells. Leukaemia inhibitory factor (LIF), sustains proliferation and not differentiation of embryonic stem cells.
Debra A Carter, Andrew D Dick, Eric J Mayer, EJ Mayer, EJ Mayer, DA Carter, V Coskun, PE Nickerson, CM Morshead, NE Knox Cartwright, S Sell, CM Morshead, SA Goldman, EJ Mayer, D Mizrak, P Barraud, S Corti, N Uchida, A Weigmann, S Miraglia, AH Yin, SV Shmelkov, MA Maw, R Handgretinger, S Yu, DK Smith, R Lemke, R Lemke, S Bauer, M Pitman, RA Irizarry, LM Cope, D Greenbaum, RE Davey, K Jin, A Wilson, MZ Ratajczak, MW Djojosubroto, C Wiese, AV Gilyarov, S Couillard-Despres, TL Walker, BL Coles, K Ohta, K Canola, H Klassen, M Takahashi, I Ahmad, V Tropepe, H Xu, A Moshiri, X Zhao, M Haruta, G Sun, M Asami, AJ Fischer, S Ooto, P Mirabelli, C De Bruyn, DE Van Epps, S Hitoshi, T Marquardt, R Ashery-Padan, S Xu, W Matthews, O Rosnet, R Namikawa, AP Jadhav, TO Alexson, SX Skapek, H Herrmann, S Couillard-Despres, H Boeuf, J Wang, T Nikolova, S Bauer, D Wodarz, I Pineau, T Shimazaki, NY Ip, SS Zhang, GA Limb, GS Peh   +82 more
core   +1 more source