Results 41 to 50 of about 5,449,684 (261)

Glucocorticoid agonists enhance retinal stem cell self-renewal and proliferation

Stem Cell Research & Therapy, 2021
Background Adult mammalian retinal stem cells (RSCs) readily proliferate, self-renew, and generate progeny that differentiate into all retinal cell types in vitro.
Kenneth N. Grisé, Nelson X. Bautista, Krystal Jacques, Brenda L. K. Coles, Derek van der Kooy   +4 more
doaj   +1 more source

Retinal progenitor cells (jCell) for retinitis pigmentosa

Frontiers in Cellular Neuroscience
ObjectiveTo assess the safety and tolerability of intravitreal injection of human retinal progenitor cells (RPCs) at multiple dose levels in adults with non-syndromic retinitis pigmentosa (RP).DesignA prospective, multicenter, open-label, single-arm, Phase I/IIa safety study of RPCs in adults with RP (n = 28). Two patient cohorts were studied: Cohort 1:
Yang, Jing, Kuppermann, Baruch D, Liao, David, Mehta, Mitul C, Hsiang, Chinhui, Menges, Steven, Boyer, David S, Klassen, Henry   +7 more
openaire   +3 more sources

Molecular Characterization of Human Retinal Progenitor Cells

Investigative Opthalmology & Visual Science, 2009
To examine the molecular profile of fetal human retinal progenitor cells (hRPCs) expanded in vitro and those grown in a co-culture system with mouse retina through the analysis of protein and gene expression and neurotransmitter-stimulated calcium dynamics.hRPCS were isolated from human retina of 14 to 18 weeks gestational age (GA) and expanded in ...
Scott, Schmitt, Unber, Aftab, Caihui, Jiang, Stephen, Redenti, Henry, Klassen, Erik, Miljan, John, Sinden, Michael, Young   +7 more
openaire   +2 more sources

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Activation of c-Jun N-terminal kinase (JNK) during mitosis in retinal progenitor cells. [PDF]

PLoS ONE, 2012
Most studies of c-Jun N-terminal Kinase (JNK) activation in retinal tissue were done in the context of neurodegeneration. In this study, we investigated the behavior of JNK during mitosis of progenitor cells in the retina of newborn rats.
Vinicius Toledo Ribas, Bruno Souza Gonçalves, Rafael Linden, Luciana Barreto Chiarini   +3 more
doaj   +1 more source

A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouse [PDF]

, 2006
Neural stem and progenitor cells are located in the subependyma of the adult forebrain. An increase in adult subependymal cell proliferation is reported after various kinds of brain injury.
Batista, C.M.C., Akamatsu, W., Shimabukuro, M.K., Kippin, T.E., Willaime-Morawek, S., van der Kooy, D.   +5 more
core   +1 more source

PlexinA2 and Sema6A are required for retinal progenitor cell migration [PDF]

Development, Growth & Differentiation, 2016
In the vertebrate retina six types of neurons and one glial cell type are generated from multipotent retinal progenitor cells (RPCs) whose proliferation and differentiation are regulated by intrinsic and extrinsic factors. RPCs proliferate undergoing interkinetic nuclear migration within the neuroblastic layer, with their nuclei moving up and down ...
Belle, Morgane, Parray, Aijaz, Belle, Martin, Chédotal, Alain, Nguyen-Ba-Charvet, Kim Tuyen   +4 more
openaire   +3 more sources

Prostaglandin E Positively Modulates Endothelial Progenitor Cell Homeostasis: An Advanced Treatment Modality for Autologous Cell Therapy [PDF]

, 2009
Aims: The mobilization of endothelial progenitor cells (EPC) and their functioning in postnatal neovascularization are tightly regulated. To identify new modulators of EPC homeostasis, we screened biologically active prostaglandin E compounds for their ...
Hermann, Patrick C., Schwarz, Theresa M., Kopp, Reinhard, Huber, Stephan, Heeschen, Christopher, Herrler, Tanja, Leicht, Simon F.   +6 more
core   +1 more source

Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression. [PDF]

PLoS ONE, 2016
During retinogenesis seven different cell types are generated in distinct yet overlapping timepoints from a population of retinal progenitor cells.
Jillian J Goetz, Lauren A Laboissonniere, Andrea K Wester, Madison R Lynch, Jeffrey M Trimarchi   +4 more
doaj   +1 more source

In Vitro Isolation and Expansion of Human Retinal Progenitor Cells [PDF]

Experimental Neurology, 2002
Human retinal development proceeds with temporal and spatial precision. Although differentiation starts around the beginning of the third month of gestation, the majority of cells in the outer neuroblastic layer of human neural retina are still proliferating, as evidenced by their Ki-67 immunoreactivity.
Yang, Peng, Seiler, Magdalene J, Aramant, Robert B, Whittemore, Scott R   +3 more
openaire   +4 more sources