Intravitreal Injection of Human Retinal Progenitor Cells for Treatment of Retinal Degeneration [PDF]
Medical Science Monitor, 2020 BACKGROUND Retinal degeneration causes irreversible blindness. Human retinal progenitor cells (hRPCs) have the potential to treat retinal diseases. The vitreous cavity is a relatively immune-privileged site that is suitable for stem cell transplantation in the treatment of retinal diseases.
Wang, Zhuoshi +7 more
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Expression of SIRT1 and DBC1 in Developing and Adult Retinas
Stem Cells International, 2012 Sirtuin 1 (SIRT1) is a deacetylase that can regulate various biological processes via repression of transcription. Its activity has been linked to the differentiation of neural progenitor cells, although little is known about its function during retinal ...
Shawn C. Maloney +7 more
doaj +1 more source
Adult limbal neurosphere cells: a potential autologous cell resource for retinal cell generation.
PLoS ONE, 2014 The Corneal limbus is a readily accessible region at the front of the eye, separating the cornea and sclera. Neural colonies (neurospheres) can be generated from adult corneal limbus in vitro.
Xiaoli Chen +5 more
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Clues from Crouzon: Insights into the potential role of growth factors in the pathogenesis of myelinated retinal nerve fibers. [PDF]
, 2016 PurposeWe present a case of bilateral extensive peripapillary myelinated retinal nerve fibers (MRNF) in an individual with Crouzon syndrome, an inherited form of craniosynostosis caused by overactivation of fibroblast growth factor receptor 2.
Akil, Handan +5 more
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Progress of stem/progenitor cell-based therapy for retinal degeneration
Journal of Translational Medicine, 2017 Retinal degeneration (RD), such as age-related macular degeneration (AMD) and retinitis pigmentosa, is one of the leading causes of blindness. Presently, no satisfactory therapeutic options are available for these diseases principally because the retina ...
Zhimin Tang +6 more
doaj +1 more source
Notch pathway mutants do not equivalently perturb mouse embryonic retinal development.
PLoS Genetics, 2023 In the vertebrate eye, Notch ligands, receptors, and ternary complex components determine the destiny of retinal progenitor cells in part by regulating Hes effector gene activity. There are multiple paralogues for nearly every node in this pathway, which
Bernadett Bosze +4 more
doaj +1 more source
The ratio of VEGF/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization [PDF]
, 2011 Angiogenesis, or neovascularization, is a finely balanced process controlled by pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is a major pro-angiogenic factor, whereas pigment epithelial-derived factor (PEDF) is the most ...
Crawford, Ross, Fan, Wei, Xiao, Yin
core +2 more sources
Cell Fate of Retinal Progenitor Cells: In Ovo UbC-StarTrack Analysis
International Journal of Molecular Sciences, 2022 Clonal cell analysis outlines the ontogenic potential of single progenitor cells, allowing the elucidation of the neural heterogeneity among different cell types and their lineages. In this work, we analyze the potency of retinal stem/progenitor cells through development using the chick embryo as a model.
Cindy L. Olmos-Carreño +3 more
openaire +4 more sources
The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina
Cell Reports, 2017 Summary: Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal ...
Taejeong Ha +8 more
doaj +1 more source
Glucocorticoid agonists enhance retinal stem cell self-renewal and proliferation
Stem Cell Research & Therapy, 2021 Background Adult mammalian retinal stem cells (RSCs) readily proliferate, self-renew, and generate progeny that differentiate into all retinal cell types in vitro.
Kenneth N. Grisé +4 more
doaj +1 more source