Results 31 to 40 of about 48,539 (287)
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2021 The developing retina expresses multiple bHLH transcription factors. Their precise functions and interactions in uncommitted retinal progenitors remain to be fully elucidated.
Xiangmei Zhang +9 more
doaj +1 more source
A Defective Crosstalk Between Neurons and Müller Glial Cells in the rd1 Retina Impairs the Regenerative Potential of Glial Stem Cells [PDF]
, 2019 Müller glial cells (MGC) are stem cells in the retina. Although their regenerative capacity is very low in mammals, the use of MGC as stem cells to regenerate photoreceptors (PHRs) during retina degenerations, such as in retinitis pigmentosa, is being ...
Ayala Peña, Victoria Belen +10 more
core +1 more source
A Model for Investigating Developmental Eye Repair in Xenopus Laevis [PDF]
, 2018 Vertebrate eye development is complex and requires early interactions between neuroectoderm and surface ectoderm during embryogenesis. In the African clawed frog, Xenopus laevis, individual eye tissues such as the retina and lens can undergo regeneration.
Kha, Cindy X. +3 more
core +2 more sources
Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis. [PDF]
PLoS Genetics, 2013 Development in the central nervous system is highly dependent on the regulation of the switch from progenitor cell proliferation to differentiation, but the molecular and cellular events controlling this process remain poorly understood.
Lucie P Pellissier +15 more
doaj +1 more source
Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]
, 2013 Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Plate, Karl H. +2 more
core +1 more source
Characterization of Progenitor Cells during Canine Retinal Development [PDF]
Stem Cells International, 2012 We identify the presence of progenitor cells during retinal development in the dog, as this species represents a natural model for studying several breed-specific degenerative retinal disorders. Antibodies to detected progenitor cells (Pax6, C-kit, and nestin) and ganglion cells (BDNF, Brn3a, and Thy1) were used in combination with H3 for the purpose ...
Mallely Ávila-García +3 more
openaire +3 more sources
Cell Transplantation, 2010 Human fetal retinal cells have been widely advocated for the development of cellular replacement therapies in patients with retinal dystrophies and age-related macular degeneration.
Shazeen M. Hasan +5 more
doaj +1 more source
eLife, 2020 During vertebrate retinal development, subsets of progenitor cells generate progeny in a non-stochastic manner, suggesting that these decisions are tightly regulated.
Miruna Georgiana Ghinia Tegla +5 more
doaj +1 more source
Engineering Retina from Human Retinal Progenitors (Cell Lines) [PDF]
Tissue Engineering Part A, 2009 Retinal degeneration resulting in the loss of photoreceptors is the leading cause of blindness. Several therapeutic protocols are under consideration for treatment of this disease. Tissue replacement is one such strategy currently being explored. However, availability of tissues for transplant poses a major obstacle.
Kamla, Dutt, Yang, Cao
openaire +2 more sources