Results 31 to 40 of about 5,449,684 (261)
Damaging effect of ischemia on the development of retinal organoids derived from human embryonic stem cells [PDF]
International Journal of OphthalmologyAIM: To explore the changes in early retinal development after the occurrence of ischemia. METHODS: Human retinal organoids (hROs) of day 18 or day 30 were treated with oxygen-glucose deprivation and reperfusion (OGD/R) to simulate the retinal ischemia ...
Yu-Han Yan +12 more
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Expression of SIRT1 and DBC1 in Developing and Adult Retinas
Stem Cells International, 2012 Sirtuin 1 (SIRT1) is a deacetylase that can regulate various biological processes via repression of transcription. Its activity has been linked to the differentiation of neural progenitor cells, although little is known about its function during retinal ...
Shawn C. Maloney +7 more
doaj +1 more source
Efficacy and Safety of Human Retinal Progenitor Cells
Translational Vision Science & Technology, 2016 We assessed the long-term efficacy and safety of human retinal progenitor cells (hRPC) using established rodent models.Efficacy of hRPC was tested initially in Royal College of Surgeons (RCS) dystrophic rats immunosuppressed with cyclosporine/dexamethasone.
Semo, M +9 more
openaire +3 more sources
Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis. [PDF]
PLoS Genetics, 2013 Development in the central nervous system is highly dependent on the regulation of the switch from progenitor cell proliferation to differentiation, but the molecular and cellular events controlling this process remain poorly understood.
Lucie P Pellissier +15 more
doaj +1 more source
eLife, 2020 During vertebrate retinal development, subsets of progenitor cells generate progeny in a non-stochastic manner, suggesting that these decisions are tightly regulated.
Miruna Georgiana Ghinia Tegla +5 more
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The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina
Cell Reports, 2017 Summary: Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal ...
Taejeong Ha +8 more
doaj +1 more source
Neural Regeneration ResearchOur previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplantation of retinal progenitor cells ...
Chunge Ren +12 more
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Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells
Basic and Clinical Neuroscience, 2021 Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host
Hamid Aboutaleb Kadkhodaeian
doaj
Notch pathway mutants do not equivalently perturb mouse embryonic retinal development.
PLoS Genetics, 2023 In the vertebrate eye, Notch ligands, receptors, and ternary complex components determine the destiny of retinal progenitor cells in part by regulating Hes effector gene activity. There are multiple paralogues for nearly every node in this pathway, which
Bernadett Bosze +4 more
doaj +1 more source
, 2020 Recent advances in cell transplantation technologies have shown that polymeric fibrous tissue-engineered scaffolds provide a suitable physical environment, including the structural support, for cell delivery and effectively mimic the transplanted cells ...
Masaeli, Elahe +9 more
core +1 more source