Results 31 to 40 of about 24,391 (241)

Expression of SIRT1 and DBC1 in Developing and Adult Retinas

Stem Cells International, 2012
Sirtuin 1 (SIRT1) is a deacetylase that can regulate various biological processes via repression of transcription. Its activity has been linked to the differentiation of neural progenitor cells, although little is known about its function during retinal ...
Shawn C. Maloney, Emilia Antecka, Alexandre N. Odashiro, Bruno F. Fernandes, Madeline Doyle, Li-Anne Lim, Yousef Katib, Miguel N. Burnier   +7 more
doaj   +1 more source

OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification

eLife, 2020
During vertebrate retinal development, subsets of progenitor cells generate progeny in a non-stochastic manner, suggesting that these decisions are tightly regulated.
Miruna Georgiana Ghinia Tegla, Diego F Buenaventura, Diana Y Kim, Cassandra Thakurdin, Kevin C Gonzalez, Mark M Emerson   +5 more
doaj   +1 more source

Notch pathway mutants do not equivalently perturb mouse embryonic retinal development.

PLoS Genetics, 2023
In the vertebrate eye, Notch ligands, receptors, and ternary complex components determine the destiny of retinal progenitor cells in part by regulating Hes effector gene activity. There are multiple paralogues for nearly every node in this pathway, which
Bernadett Bosze, Julissa Suarez-Navarro, Illiana Cajias, Joseph A Brzezinski Iv, Nadean L Brown   +4 more
doaj   +1 more source

Bipotent progenitors as embryonic origin of retinal stem cells [PDF]

Journal of Cell Biology, 2017
In lower vertebrates, retinal stem cells (RSCs) capable of producing all retinal cell types are a resource for retinal tissue growth throughout life. However, the embryonic origin of RSCs remains largely elusive. Using a Zebrabow-based clonal analysis, we characterized the RSC niche in the ciliary marginal zone of zebrafish retina and illustrate that ...
Xia Tang, Jianan Gao, Xinling Jia, Wencao Zhao, Yijie Zhang, Weijun Pan, Jie He   +6 more
openaire   +2 more sources

Efficacy and Safety of Human Retinal Progenitor Cells

Translational Vision Science & Technology, 2016
We assessed the long-term efficacy and safety of human retinal progenitor cells (hRPC) using established rodent models.Efficacy of hRPC was tested initially in Royal College of Surgeons (RCS) dystrophic rats immunosuppressed with cyclosporine/dexamethasone.
Semo, M, Haamedi, N, Stevanato, L, Carter, D, Brooke, G, Young, M, Coffey, P, Sinden, J, Patel, S, Vugler, A   +9 more
openaire   +3 more sources

In Vitro Isolation and Expansion of Human Retinal Progenitor Cells [PDF]

Experimental Neurology, 2002
Human retinal development proceeds with temporal and spatial precision. Although differentiation starts around the beginning of the third month of gestation, the majority of cells in the outer neuroblastic layer of human neural retina are still proliferating, as evidenced by their Ki-67 immunoreactivity.
Yang, Peng, Seiler, Magdalene J, Aramant, Robert B, Whittemore, Scott R   +3 more
openaire   +4 more sources

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina

Cell Reports, 2017
Summary: Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal ...
Taejeong Ha, Kyeong Hwan Moon, Le Dai, Jun Hatakeyama, Keejung Yoon, Hee-Sae Park, Young-Yoon Kong, Kenji Shimamura, Jin Woo Kim   +8 more
doaj   +1 more source

Glucocorticoid agonists enhance retinal stem cell self-renewal and proliferation

Stem Cell Research & Therapy, 2021
Background Adult mammalian retinal stem cells (RSCs) readily proliferate, self-renew, and generate progeny that differentiate into all retinal cell types in vitro.
Kenneth N. Grisé, Nelson X. Bautista, Krystal Jacques, Brenda L. K. Coles, Derek van der Kooy   +4 more
doaj   +1 more source

Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1 [PDF]

, 2009
Background. In Xenopus retinogenesis, p27Xic1, a Xenopus cyclin dependent kinase inhibitor, functions as a cell fate determinant in both gliogenesis and neurogenesis in a context dependent manner.
Toshiaki Mochizuki, Zollo Massimo, Ohnuma, S-I, Bilitou, A, Bilitou Aikaterini, Ohnuma Shin-ichi, Waters Caroline T, Massimo Zollo, Shin-ichi Ohnuma, Mochizuki, Toshiaki, Aikaterini Bilitou, Kamran Hussain, Caroline T Waters, Hussain Kamran, Zollo, M, Waters, CT, Mochizuki Toshiaki, Hussain, K, Mochizuki, T   +18 more
core   +1 more source

Molecular Characterization of Human Retinal Progenitor Cells

Investigative Opthalmology & Visual Science, 2009
To examine the molecular profile of fetal human retinal progenitor cells (hRPCs) expanded in vitro and those grown in a co-culture system with mouse retina through the analysis of protein and gene expression and neurotransmitter-stimulated calcium dynamics.hRPCS were isolated from human retina of 14 to 18 weeks gestational age (GA) and expanded in ...
Scott, Schmitt, Unber, Aftab, Caihui, Jiang, Stephen, Redenti, Henry, Klassen, Erik, Miljan, John, Sinden, Michael, Young   +7 more
openaire   +2 more sources