Evidence for a retinal progenitor cell in the postnatal and adult mouse [PDF]
Stem Cell Research, 2017 Progress in cell therapy for retinal disorders has been challenging. Recognized retinal progenitors are a heterogeneous population of cells that lack surface markers for the isolation of live cells for clinical implementation. In the present application,
Xi Chen +10 more
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Adult limbal neurosphere cells: a potential autologous cell resource for retinal cell generation. [PDF]
PLoS ONE, 2014 The Corneal limbus is a readily accessible region at the front of the eye, separating the cornea and sclera. Neural colonies (neurospheres) can be generated from adult corneal limbus in vitro.
Xiaoli Chen +5 more
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Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina [PDF]
Nature CommunicationsThe emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal development.
Birthe Dorgau +13 more
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Progress of stem/progenitor cell-based therapy for retinal degeneration
Journal of Translational Medicine, 2017 Retinal degeneration (RD), such as age-related macular degeneration (AMD) and retinitis pigmentosa, is one of the leading causes of blindness. Presently, no satisfactory therapeutic options are available for these diseases principally because the retina ...
Zhimin Tang +6 more
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Cell Fate of Retinal Progenitor Cells: In Ovo UbC-StarTrack Analysis [PDF]
International Journal of Molecular Sciences, 2022 Clonal cell analysis outlines the ontogenic potential of single progenitor cells, allowing the elucidation of the neural heterogeneity among different cell types and their lineages. In this work, we analyze the potency of retinal stem/progenitor cells through development using the chick embryo as a model.
Cindy L. Olmos-Carreño +3 more
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Histone methyltransferase Setd8 preserves chromatin accessibility to safeguard retinal progenitor cell identity during development [PDF]
Stem Cell ReportsDynamic epigenetic changes guide retinal progenitor cells (RPCs) toward diverse neuronal subtypes and Mu¨ller glia during retinal development. However, the epigenetic mechanisms that maintain RPC proliferative and neurogenic potential throughout the ...
Oda, Hisanobu +9 more
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Ten-Eleven Translocation Enzymes Control the Rate and Mode of Retinal Progenitor Cell Division in the Developing Retina. [PDF]
FASEB JEarly RPCs divide predominantly symmetrically and exhibit a high proliferation rate, resulting in rapid retinal growth. Late RPCs divide predominantly asymmetrically and exhibit a low proliferation rate. Our results suggest that TET‐deficient RPCs divide predominantly asymmetrically but exhibit a high proliferation rate.
Dvoriantchikova G +3 more
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Cell Reports, 2023 Summary: Neural progenitor cells lengthen their cell cycle to prime themselves for differentiation as development proceeds. It is currently not clear how they counter this lengthening and avoid being halted in the cell cycle.
Liang Li +8 more
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Müller Glia Subtypes Define Neuro-Glial Associations and Spatial Morphogen Axes in the Zebrafish Retina. [PDF]
GliaZebrafish Müller glia are heterogeneous in the early larval retina. Zebrafish Müller glia subtypes define a spatial axis of retinoic acid metabolism. Neuron‐associated glial programs identified in Zebrafish Müller glia are evolutionarily conserved in mammals. ABSTRACT Müller glia are instrumental macroglia of the vertebrate retina, once thought to be a
Storey SS +3 more
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Patterns of Proliferation in the Pacific Hagfish (Eptatretus stoutii) Retina Suggest an Ancient Origin for Adult Neurogenesis. [PDF]
J Comp NeurolThe hagfish, a jawless early‐branching vertebrate, has very rudimentary eyes that are diminutive and oddly devoid of melanin pigment. Yet, the degenerate hagfish eye grows throughout life and expresses canonical genes of vertebrate retinal development. ABSTRACT Comparative morphology has revealed fascinating structural and organizational differences in
Bradshaw SN, Allison WT.
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