Results 11 to 20 of about 48,539 (287)

Human retinal progenitor cell transplantation preserves vision. [PDF]

J Biol Chem, 2014
Cell transplantation is a potential therapeutic strategy for retinal degenerative diseases involving the loss of photoreceptors. However, it faces challenges to clinical translation due to safety concerns and a limited supply of cells. Human retinal progenitor cells (hRPCs) from fetal neural retina are expandable in vitro and maintain an ...
Luo J, Baranov P, Patel S, Ouyang H, Quach J, Wu F, Qiu A, Luo H, Hicks C, Zeng J, Zhu J, Lu J, Sfeir N, Wen C, Zhang M, Reade V, Patel S, Sinden J, Sun X, Shaw P, Young M, Zhang K.   +21 more
europepmc   +6 more sources

A microfabricated scaffold for retinal progenitor cell grafting [PDF]

Biomaterials, 2008
Diseases that cause photoreceptor cell degeneration afflict millions of people, yet no restorative treatment exists for these blinding disorders. Replacement of photoreceptors using retinal progenitor cells (RPCs) represents a promising therapy for the treatment of retinal degeneration.
William L, Neeley, Stephen, Redenti, Henry, Klassen, Sarah, Tao, Tejal, Desai, Michael J, Young, Robert, Langer   +6 more
openaire   +4 more sources

Efficacy and Safety of Human Retinal Progenitor Cells. [PDF]

Translational Vision Science & Technology, 2016
PURPOSE: We assessed the long-term efficacy and safety of human retinal progenitor cells (hRPC) using established rodent models. METHODS: Efficacy of hRPC was tested initially in Royal College of Surgeons (RCS) dystrophic rats immunosuppressed with ...
Brooke, G, Carter, D, Coffey, P, Haamedi, N, Patel, S, Semo, M, Sinden, J, Stevanato, L, Vugler, A, Young, M   +9 more
core   +9 more sources

Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

Nature Communications, 2019
Stem cell transplantation to treat retinal degeneration could be limited by the degenerative microenvironment. Here, the authors show that C-Kit+/SSEA4– progenitor cells enriched from human embryonic stem cell derived retinal organoids protect retinal ...
Ting Zou, Lixiong Gao, Yuxiao Zeng, Qiyou Li, Yijian Li, Siyu Chen, Xisu Hu, Xi Chen, Caiyun Fu, Haiwei Xu, Zheng Qin Yin   +10 more
doaj   +2 more sources

Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina

Nature Communications
The emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal development.
Birthe Dorgau, Joseph Collin, Agata Rozanska, Darin Zerti, Adrienne Unsworth, Moira Crosier, Rafiqul Hussain, Jonathan Coxhead, Tamil Dhanaseelan, Aara Patel, Jane C. Sowden, David R. FitzPatrick, Rachel Queen, Majlinda Lako   +13 more
doaj   +2 more sources

Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells [PDF]

Basic and Clinical Neuroscience, 2021
Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host
Hamid Aboutaleb Kadkhodaeian
doaj   +3 more sources

Morphological asymmetry in dividing retinal progenitor cells [PDF]

Development, Growth & Differentiation, 2003
For the understanding of histogenetic events in the 3‐D retinal neuroepithelium, direct observation of the progenitor cells and their morphological changes is required. A slice culture method has been developed by which the behavior of single progenitor cells can be monitored.
Kanako, Saito, Ayano, Kawaguchi, Saori, Kashiwagi, Sadao, Yasugi, Masaharu, Ogawa, Takaki, Miyata   +5 more
openaire   +2 more sources

SURGICAL RETINAL EXPLANTS AS A SOURCE OF RETINAL PROGENITOR CELLS

Retina, 2021
Purpose: To describe the novel observation of spontaneously migrating retinal cells from living donor surgical retinal explants that express progenitor cell markers in the absence of exogenous growth factors. Methods: Surgical retinal explants were harvested from 5 consecutive ...
Too, Lay Khoon, Shen, Weiyong, Mammo, Zaid, Osaadon, Perach, Gillies, Mark C., Simunovic, Matthew P.   +5 more
openaire   +3 more sources

Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration

eLife, 2023
In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor production and neuronal ...
Laura Celotto, Fabian Rost, Anja Machate, Juliane Bläsche, Andreas Dahl, Anke Weber, Stefan Hans, Michael Brand   +7 more
doaj   +1 more source

Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. [PDF]

, 2018
The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events.
Hashimoto, Takao, Tang, Ronald, Yang, Xian-Jie, Zhang, Xiang-Mei   +3 more
core   +1 more source