Results 1 to 10 of about 387 (69)

Bifunctional MXene‐Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration

Advanced Science, 2023
Retinal degeneration, characterized by the progressive loss of retinal neurons, is the leading cause of incurable visual impairment. Retinal progenitor cells (RPCs)‐based transplantation can facilitate sight restoration, but the clinical efficacy of this
Zhimin Tang, Yan Liu, Huijing Xiang, Xinyue Dai, Xiaolin Huang, Yahan Ju, Ni Ni, Rui Huang, Huiqin Gao, Jing Zhang, Xianqun Fan, Yun Su, Yu Chen, Ping Gu   +13 more
doaj   +2 more sources

Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1

Cell Reports, 2023
Summary: Transitions in competence underlie the ability of CNS progenitors to generate a diversity of neurons and glia. Retinal progenitor cells in mouse generate early-born cell types embryonically and late-born cell types largely postnatally.
Jianmin Zhang, Jacqueline M. Roberts, Fei Chang, Joon Schwakopf, Monica L. Vetter   +4 more
doaj   +1 more source

Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states

Scientific Reports, 2021
Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells.
Xueqing Chen, Mark M. Emerson
doaj   +1 more source

Novel Technique for Retinal Nerve Cell Regeneration with Electrophysiological Functions Using Human Iris-Derived iPS Cells

Cells, 2021
Regenerative medicine in ophthalmology that uses induced pluripotent stem cells (iPS) cells has been described, but those studies used iPS cells derived from fibroblasts.
Naoki Yamamoto, Noriko Hiramatsu, Mahito Ohkuma, Natsuko Hatsusaka, Shun Takeda, Noriaki Nagai, Ei-ichi Miyachi, Masashi Kondo, Kazuyoshi Imaizumi, Masayuki Horiguchi, Eri Kubo, Hiroshi Sasaki   +11 more
doaj   +1 more source

Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

Nature Communications, 2023
Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes through Müller glia (MG) reprogramming and asymmetric cell division that produces a multipotent Müller glia-derived neuronal progenitor cell (MGPC).
Pin Lyu, Maria Iribarne, Dmitri Serjanov, Yijie Zhai, Thanh Hoang, Leah J. Campbell, Patrick Boyd, Isabella Palazzo, Mikiko Nagashima, Nicholas J. Silva, Peter F. Hitchcock, Jiang Qian, David R. Hyde, Seth Blackshaw   +13 more
doaj   +1 more source

Cell Replacement Therapy for Retinal and Optic Nerve Diseases: Cell Sources, Clinical Trials and Challenges

Pharmaceutics, 2021
The aim of this review was to provide an update on the potential of cell therapies to restore or replace damaged and/or lost cells in retinal degenerative and optic nerve diseases, describing the available cell sources and the challenges involved in such
Rosa M. Coco-Martin, Salvador Pastor-Idoate, Jose Carlos Pastor   +2 more
doaj   +1 more source

Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration

eLife, 2023
In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor production and neuronal ...
Laura Celotto, Fabian Rost, Anja Machate, Juliane Bläsche, Andreas Dahl, Anke Weber, Stefan Hans, Michael Brand   +7 more
doaj   +1 more source

Enhanced generation of retinal progenitor cells from human retinal pigment epithelial cells induced by amniotic fluid

BMC Research Notes, 2012
Background Retinal progenitor cells are a convenient source of cell replacement therapy in retinal degenerative disorders. The purpose of this study was to evaluate the expression patterns of the homeobox genes PAX6 and CHX10 (retinal progenitor markers)
Sanie-Jahromi Fatemeh, Ahmadieh Hamid, Soheili Zahra-Soheila, Davari Maliheh, Ghaderi Shima, Kanavi Mozhgan, Samiei Shahram, Deezagi Abdolkhalegh, Pakravesh Jalil, Bagheri Abouzar   +9 more
doaj   +1 more source

Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid Development

Frontiers in Cell and Developmental Biology, 2021
The developing retina expresses multiple bHLH transcription factors. Their precise functions and interactions in uncommitted retinal progenitors remain to be fully elucidated.
Xiangmei Zhang, Igor Mandric, Kevin H. Nguyen, Thao T. T. Nguyen, Matteo Pellegrini, James C. R. Grove, Steven Barnes, Steven Barnes, Xian-Jie Yang, Xian-Jie Yang   +9 more
doaj   +1 more source

Immortalized Human Fetal Retinal Cells Retain Progenitor Characteristics and Represent a Potential Source for the Treatment of Retinal Degenerative Disease

Cell Transplantation, 2010
Human fetal retinal cells have been widely advocated for the development of cellular replacement therapies in patients with retinal dystrophies and age-related macular degeneration.
Shazeen M. Hasan, Anthony A. Vugler, Erik A. Miljan, John D. Sinden, Stephen E. Moss, John Greenwood   +5 more
doaj   +1 more source