Results 1 to 10 of about 24,391 (241)

Bifunctional MXene‐Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration [PDF]

Advanced Science, 2023
Retinal degeneration, characterized by the progressive loss of retinal neurons, is the leading cause of incurable visual impairment. Retinal progenitor cells (RPCs)‐based transplantation can facilitate sight restoration, but the clinical efficacy of this
Zhimin Tang, Yan Liu, Huijing Xiang, Xinyue Dai, Xiaolin Huang, Yahan Ju, Ni Ni, Rui Huang, Huiqin Gao, Jing Zhang, Xianqun Fan, Yun Su, Yu Chen, Ping Gu   +13 more
doaj   +5 more sources

Evidence for a retinal progenitor cell in the postnatal and adult mouse [PDF]

Stem Cell Research, 2017
Progress in cell therapy for retinal disorders has been challenging. Recognized retinal progenitors are a heterogeneous population of cells that lack surface markers for the isolation of live cells for clinical implementation. In the present application,
Xi Chen, Shaojun Wang, Haiwei Xu, Joao D. Pereira, Konstantinos E. Hatzistergos, Dieter Saur, Barbara Seidler, Joshua M. Hare, Mark A. Perrella, Zheng Qin Yin, Xiaoli Liu   +10 more
doaj   +5 more sources

Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states [PDF]

Scientific Reports, 2021
Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells.
Xueqing Chen, Mark M. Emerson
doaj   +3 more sources

Human retinal progenitor cell transplantation preserves vision. [PDF]

J Biol Chem, 2014
Cell transplantation is a potential therapeutic strategy for retinal degenerative diseases involving the loss of photoreceptors. However, it faces challenges to clinical translation due to safety concerns and a limited supply of cells.
Luo J, Baranov P, Patel S, Ouyang H, Quach J, Wu F, Qiu A, Luo H, Hicks C, Zeng J, Zhu J, Lu J, Sfeir N, Wen C, Zhang M, Reade V, Patel S, Sinden J, Sun X, Shaw P, Young M, Zhang K.   +21 more
europepmc   +6 more sources

Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina [PDF]

Nature Communications
The emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal development.
Birthe Dorgau, Joseph Collin, Agata Rozanska, Darin Zerti, Adrienne Unsworth, Moira Crosier, Rafiqul Hussain, Jonathan Coxhead, Tamil Dhanaseelan, Aara Patel, Jane C. Sowden, David R. FitzPatrick, Rachel Queen, Majlinda Lako   +13 more
doaj   +5 more sources

Adult limbal neurosphere cells: a potential autologous cell resource for retinal cell generation.

PLoS ONE, 2014
The Corneal limbus is a readily accessible region at the front of the eye, separating the cornea and sclera. Neural colonies (neurospheres) can be generated from adult corneal limbus in vitro.
Xiaoli Chen, Heather Thomson, Jessica Cooke, Jennifer Scott, Parwez Hossain, Andrew Lotery   +5 more
doaj   +2 more sources

Enhanced generation of retinal progenitor cells from human retinal pigment epithelial cells induced by amniotic fluid

BMC Research Notes, 2012
Background Retinal progenitor cells are a convenient source of cell replacement therapy in retinal degenerative disorders. The purpose of this study was to evaluate the expression patterns of the homeobox genes PAX6 and CHX10 (retinal progenitor markers)
Sanie-Jahromi Fatemeh, Ahmadieh Hamid, Soheili Zahra-Soheila, Davari Maliheh, Ghaderi Shima, Kanavi Mozhgan, Samiei Shahram, Deezagi Abdolkhalegh, Pakravesh Jalil, Bagheri Abouzar   +9 more
doaj   +2 more sources

Progress of stem/progenitor cell-based therapy for retinal degeneration

Journal of Translational Medicine, 2017
Retinal degeneration (RD), such as age-related macular degeneration (AMD) and retinitis pigmentosa, is one of the leading causes of blindness. Presently, no satisfactory therapeutic options are available for these diseases principally because the retina ...
Zhimin Tang, Yi Zhang, Yuyao Wang, Dandan Zhang, Bingqiao Shen, Min Luo, Ping Gu   +6 more
doaj   +2 more sources

Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells

Cell Reports, 2023
Summary: Neural progenitor cells lengthen their cell cycle to prime themselves for differentiation as development proceeds. It is currently not clear how they counter this lengthening and avoid being halted in the cell cycle.
Liang Li, Yue Sun, Alexander E. Davis, Sahil H. Shah, Lobna K. Hamed, Man-Ru Wu, Cheng-Hui Lin, Jun B. Ding, Sui Wang   +8 more
doaj   +3 more sources

Immortalized Human Fetal Retinal Cells Retain Progenitor Characteristics and Represent a Potential Source for the Treatment of Retinal Degenerative Disease

Cell Transplantation, 2010
Human fetal retinal cells have been widely advocated for the development of cellular replacement therapies in patients with retinal dystrophies and age-related macular degeneration.
Shazeen M. Hasan, Anthony A. Vugler, Erik A. Miljan, John D. Sinden, Stephen E. Moss, John Greenwood   +5 more
doaj   +2 more sources