Bifunctional MXene‐Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration [PDF]
Advanced Science, 2023 Retinal degeneration, characterized by the progressive loss of retinal neurons, is the leading cause of incurable visual impairment. Retinal progenitor cells (RPCs)‐based transplantation can facilitate sight restoration, but the clinical efficacy of this
Zhimin Tang +13 more
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Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states [PDF]
Scientific Reports, 2021 Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells.
Xueqing Chen, Mark M. Emerson
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Evidence for a retinal progenitor cell in the postnatal and adult mouse [PDF]
Stem Cell Research, 2017 Progress in cell therapy for retinal disorders has been challenging. Recognized retinal progenitors are a heterogeneous population of cells that lack surface markers for the isolation of live cells for clinical implementation. In the present application,
Xi Chen +10 more
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Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells [PDF]
Cell Reports, 2023 Summary: Neural progenitor cells lengthen their cell cycle to prime themselves for differentiation as development proceeds. It is currently not clear how they counter this lengthening and avoid being halted in the cell cycle.
Liang Li +8 more
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Interphotoreceptor matrix-poly(ϵ-caprolactone) composite scaffolds for human photoreceptor differentiation [PDF]
Journal of Tissue Engineering, 2014 Tissue engineering has been widely applied in different areas of regenerative medicine, including retinal regeneration. Typically, artificial biopolymers require additional surface modification (e.g. with arginine–glycine–aspartate-containing peptides or
Petr Baranov +4 more
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Damaging effect of ischemia on the development of retinal organoids derived from human embryonic stem cells [PDF]
International Journal of OphthalmologyAIM: To explore the changes in early retinal development after the occurrence of ischemia. METHODS: Human retinal organoids (hROs) of day 18 or day 30 were treated with oxygen-glucose deprivation and reperfusion (OGD/R) to simulate the retinal ischemia ...
Yu-Han Yan +12 more
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A zinc finger-dependent, PRDM13-driven mechanism regulates retinal progenitor cell fate from mouse embryonic stem cells via WNT signaling. [PDF]
Stem Cell ReportsBasinski BW +9 more
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Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1
Cell Reports, 2023 Summary: Transitions in competence underlie the ability of CNS progenitors to generate a diversity of neurons and glia. Retinal progenitor cells in mouse generate early-born cell types embryonically and late-born cell types largely postnatally.
Jianmin Zhang +4 more
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Cells, 2021 Regenerative medicine in ophthalmology that uses induced pluripotent stem cells (iPS) cells has been described, but those studies used iPS cells derived from fibroblasts.
Naoki Yamamoto +11 more
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Pharmaceutics, 2021 The aim of this review was to provide an update on the potential of cell therapies to restore or replace damaged and/or lost cells in retinal degenerative and optic nerve diseases, describing the available cell sources and the challenges involved in such
Rosa M. Coco-Martin +2 more
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