Distribution of doublecortin in the developing retina of birds: A comparative analysis
The Anatomical Record, EarlyView.Abstract The avian retina presents an elegant and highly accessible model for investigating the spatial and temporal dynamics of neurogenesis within the central nervous system. In recent years, the microtubule cytoskeleton has emerged not merely as a structural scaffold, but as a dynamic regulator of the transition of a morphologically homogeneous pool
Javier Francisco‐Morcillo +5 more
wiley +1 more source
Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]
, 2012 The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Johannes Burger +8 more
core +2 more sources
Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing
Animal Research and One Health, EarlyView.Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley +1 more source
A multipotent transit-amplifying neuroblast lineage in the central brain gives rise to optic lobe glial cells in Drosophila [PDF]
, 2013 The neurons and glial cells of the Drosophila brain are generated by neural stem cell-like progenitors during two developmental phases, one short embryonic phase and one more prolonged postembryonic phase.
Reichert, Heinrich +2 more
core +1 more source
Biotechnology and Bioengineering, EarlyView.Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney +6 more
wiley +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Conditional activation of Bmi1 in embryonic and postnatal neural stem/progenitor cells in mouse models: analysis of its effect on their biological properties and tumourigenesis [PDF]
, 2011 PhDThe Polycomb group protein Bmi1 is a key transcriptional regulator of self renewal of embryonic and adult neural stem and progenitor cells (NSPC) and its over-expression has been shown to occur in several types of brain tumour.
Yadırgı, Gökhan
core +4 more sources
PLoS ONE, 2012 Cell transplantation to treat retinal degenerative diseases represents an option for the replacement of lost photoreceptor cells. In vitro expandable cells isolated from the developing mammalian retina have been suggested as a potential source for the ...
Magdalena Czekaj +7 more
doaj +1 more source
A comparative study of the potential for human retinal pigment epithelium utilising an embryonic chick model of the phenomenon [PDF]
, 2014 The retinal pigment epithelial (RPE) cells of several species, including: chicken, rat, mouse and newt, have been observed to undergo a phenomenon known as transdifferentiation.
Smart, MJK
core
Prostaglandin E Positively Modulates Endothelial Progenitor Cell Homeostasis: An Advanced Treatment Modality for Autologous Cell Therapy [PDF]
, 2009 Aims: The mobilization of endothelial progenitor cells (EPC) and their functioning in postnatal neovascularization are tightly regulated. To identify new modulators of EPC homeostasis, we screened biologically active prostaglandin E compounds for their ...
Hermann, Patrick C. +6 more
core +1 more source