Results 81 to 90 of about 48,023 (234)

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration [PDF]

, 2014
The reprogramming of retinal pigment epithelium (RPE) cells in the adult newt immediately after retinal injury is an area of active research for the study of retinal disorders and regeneration.
Casco-Robles Martin Miguel, Chiba Chikafumi, Inami Wataru, Islam Md. Rafiqul, Kunahong Ailidana, Maruo Fumiaki, Nakamura Kenta, Toyama Fubito, 丸尾 文昭, 千葉 親文   +9 more
core   +1 more source

Bipotent progenitors as embryonic origin of retinal stem cells [PDF]

Journal of Cell Biology, 2017
In lower vertebrates, retinal stem cells (RSCs) capable of producing all retinal cell types are a resource for retinal tissue growth throughout life. However, the embryonic origin of RSCs remains largely elusive. Using a Zebrabow-based clonal analysis, we characterized the RSC niche in the ciliary marginal zone of zebrafish retina and illustrate that ...
Xia Tang, Jianan Gao, Xinling Jia, Wencao Zhao, Yijie Zhang, Weijun Pan, Jie He   +6 more
openaire   +2 more sources

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Notch Signaling Activation Enhances Human Adipose-Derived Stem Cell Retinal Differentiation

Stem Cells International, 2018
Retinal disease treatment by stem cell-based replacement relies on stem cell differentiation into retinal cells. We previously demonstrated that human periodontal ligament-derived stem cells can be directed into retinal lineage upon induction.
Yuqiang Huang, Tsz Kin Ng, Chong-Bo Chen, Bing Huang, Jiajian Liang, Chi Pui Pang, Mingzhi Zhang   +6 more
doaj   +1 more source

Damaging effect of ischemia on the development of retinal organoids derived from human embryonic stem cells [PDF]

International Journal of Ophthalmology
AIM: To explore the changes in early retinal development after the occurrence of ischemia. METHODS: Human retinal organoids (hROs) of day 18 or day 30 were treated with oxygen-glucose deprivation and reperfusion (OGD/R) to simulate the retinal ischemia ...
Yu-Han Yan, Hong-Yu Li, Li-Xiong Gao, Wen Li, Ling-Ping Zhao, Quan Zeng, Yu Luo, Tian-Tian Cui, Ru-Ge Zang, Zi Ye, Jia-Fei Xi, Wen Yue, Zhao-Hui Li   +12 more
doaj   +1 more source

A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. [PDF]

, 2012
EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly.
Ataman, Bulent, Bloodgood, Brenda L, Cowan, Christopher W, Greenberg, Michael E, Ho, Hsin-Yi Henry, Malik, Athar N, Robichaux, Michael A, Rubin, Alex A, Sharma, Nikhil, Shokat, Kevan M, Soskis, Michael J, Zhang, Chao, Zieg, Janine   +12 more
core   +1 more source

Meis1 regulates Foxn4 expression during retinal progenitor cell differentiation [PDF]

Biology Open, 2013
Summary The transcription factor forkhead box N4 (Foxn4) is a key regulator in a variety of biological processes during development. In particular, Foxn4 plays an essential role in the genesis of horizontal and amacrine neurons from neural progenitors in the vertebrate retina.
Mohammed M. Islam, Ying Li, Huijun Luo, Mengqing Xiang, Li Cai   +4 more
openaire   +3 more sources

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

In vitro expanded stem cells from the developing retina fail to generate photoreceptors but differentiate into myelinating oligodendrocytes.

PLoS ONE, 2012
Cell transplantation to treat retinal degenerative diseases represents an option for the replacement of lost photoreceptor cells. In vitro expandable cells isolated from the developing mammalian retina have been suggested as a potential source for the ...
Magdalena Czekaj, Jochen Haas, Marlen Gebhardt, Thomas Müller-Reichert, Peter Humphries, Jane Farrar, Udo Bartsch, Marius Ader   +7 more
doaj   +1 more source