Results 81 to 90 of about 4,562,862 (262)

KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons

Cytoskeleton, EarlyView.
ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung, J. Sidhu, A. Hsieh, Y. Ma, J. Liu, M. A. Silverman   +5 more
wiley   +1 more source

Notch Signaling Activation Enhances Human Adipose-Derived Stem Cell Retinal Differentiation

Stem Cells International, 2018
Retinal disease treatment by stem cell-based replacement relies on stem cell differentiation into retinal cells. We previously demonstrated that human periodontal ligament-derived stem cells can be directed into retinal lineage upon induction.
Yuqiang Huang, Tsz Kin Ng, Chong-Bo Chen, Bing Huang, Jiajian Liang, Chi Pui Pang, Mingzhi Zhang   +6 more
doaj   +1 more source

Damaging effect of ischemia on the development of retinal organoids derived from human embryonic stem cells [PDF]

International Journal of Ophthalmology
AIM: To explore the changes in early retinal development after the occurrence of ischemia. METHODS: Human retinal organoids (hROs) of day 18 or day 30 were treated with oxygen-glucose deprivation and reperfusion (OGD/R) to simulate the retinal ischemia ...
Yu-Han Yan, Hong-Yu Li, Li-Xiong Gao, Wen Li, Ling-Ping Zhao, Quan Zeng, Yu Luo, Tian-Tian Cui, Ru-Ge Zang, Zi Ye, Jia-Fei Xi, Wen Yue, Zhao-Hui Li   +12 more
doaj   +1 more source

Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support [PDF]

, 2004
Background - The mechanisms underlying the variation in collateral formation between patients, even with similar patterns of coronary artery disease, remain unclear.
Bucknall, CA, Meng, Y G, Redwood, SR, Pearson, JD, Redwood, S R, Edwards, R J, Lambiase, PD, Marber, MS, Edwards, RJ, Anthopoulos, P, Rahman, S, Lambiase, P D, Meng, YG, Pearson, J D, Marber, M S; id_orcid, Bucknall, C A   +15 more
core   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Advances in Retinal Stem Cell Biology

Journal of Ophthalmic & Vision Research, 2013
Tremendous progress has been made in recent years to generate retinal cells from pluripotent cell sources. These advances provide hope for those suffering from blindness due to lost retinal cells.
Andrea S Viczian
doaj  

Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells [PDF]

, 2003
Background— Transplantation of ex vivo expanded circulating endothelial progenitor cells (EPCs) from peripheral blood mononuclear cells improves the neovascularization after critical ischemia. However, the origin of the endothelial progenitor lineage and
Dimmeler, S, Heeschen, C, Aicher, A, Urbich, C, Zeiher, AM, Dernbach, E   +5 more
core  

Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells [PDF]

, 2012
Recombinant adeno-associated viral (rAAV) vectors can be used to introduce neurotrophic genes into injured CNS neurons, promoting survival and axonal regeneration.
Rodger Jennifer, Hellström Mats, Alan R Harvey, Jennifer Rodger, Mats Hellström, Hellström, M., Robertson, D., Harvey, A.R., Donald Robertson, Drummond Eleanor S., Harvey Alan R., Eleanor S Drummond, Rodger, J., Drummond, E.S., Robertson Donald   +14 more
core   +2 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells

Cell, 2001
Cell 105(1), 43-55 (2001).
Marquardt, Till, Ashery-Padan, Ruth, Andrejewski, Nicole, Scardigli, Raffaella, Guillemot, Francois, Gruss, Peter   +5 more
openaire   +3 more sources