Programmable active pixel sensor to investigate neural interactions within the retina [PDF]
, 2009 Detection of the visual scene by the eye and the resultant neural interactions of the retina-brain system give us our perception of sight. We have developed an Active Pixel Sensor (APS) to be used as a tool for both furthering understanding of these ...
Hart MD +5 more
core +1 more source
Temporal structure in spiking patterns of ganglion cells defines perceptual thresholds in rodents with subretinal prosthesis. [PDF]
, 2018 Subretinal prostheses are designed to restore sight in patients blinded by retinal degeneration using electrical stimulation of the inner retinal neurons.
Goetz, Georges +8 more
core +3 more sources
Keratoprostheses for corneal blindness: a review of contemporary devices [PDF]
, 2015 According to the World Health Organization, globally 4.9 million are blind due to corneal pathology. Corneal transplantation is successful and curative of the blindness for a majority of these cases. However, it is less successful in a number of diseases
Avadhanam, Venkata +2 more
core +1 more source
Adverse events associated with intraocular injection of anti-VEGF(bevacizumab) in retinal vein ccclusion: a case report [PDF]
, 2015 Introduction: Antiangiogenic agents are often administered for treatment of Branch Retinal Vein Occlusion (BRVO). Among them, Bevacizumab has noticeable antiangiogenic and antiedemigenic properties and possesses great capacity to penetrate the retinal ...
ARTICO, Marco +7 more
core +1 more source
AnIn VitroModel of a Retinal Prosthesis [PDF]
IEEE Transactions on Biomedical Engineering, 2008 Epiretinal prostheses are being developed to bypass a degenerated photoreceptor layer and excite surviving ganglion and inner retinal cells. We used custom microfabricated multielectrode arrays with 200-microm-diameter stimulating electrodes and 10-microm-diameter recording electrodes to stimulate and record neural responses in isolated tiger ...
Ashish K. Ahuja +4 more
openaire +2 more sources
Safety, effectiveness, and cost-effectiveness of Argus II in patients with retinitis pigmentosa: a systematic review [PDF]
International Journal of Ophthalmology, 2021 AIM: To assess the effectiveness, safety, and cost-effectiveness of the Argus II in treatment of the retinitis pigmentosa (RP) patients. METHODS: The ProQuest, Web of Science, EMBASE, MEDLINE (via PubMed) were searched using combinations of the keywords ...
Zakieh Ostad-Ahmadi +3 more
doaj +1 more source
Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision [PDF]
, 2012 Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Edward Wong +5 more
core +2 more sources
A clinically viable approach to restoring visual function using optogenetic gene therapy
Molecular Therapy: Methods & Clinical Development, 2023 Optogenetic gene therapies offer a promising strategy for restoring vision to patients with retinal degenerative diseases, such as retinitis pigmentosa (RP). Several clinical trials have begun in this area using different vectors and optogenetic proteins
Boyuan Yan +6 more
doaj +1 more source
Microdevices for studies of cultured neural networks [PDF]
, 2000 A cultured network has the advantages that the network is two-dimensional and easily observed, that the biochemical environment can be controlled, and that conventional electrodes as well as extracellular electrodes incorporated into the cultured ...
Pine, Jerome
core +1 more source
Wafer-Level Parylene Packaging With Integrated RF Electronics for Wireless Retinal Prostheses [PDF]
, 2010 This paper presents an embedded chip integration technology that incorporates silicon housings and flexible Parylene-based microelectromechanical systems (MEMS) devices.
Humayun, Mark S. +5 more
core +1 more source