Results 41 to 50 of about 272,086 (189)

Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis

Micromachines, 2020
We present a retrospective of unique micro-fabrication problems and solutions that were encountered through over 10 years of retinal prosthesis product development, first for the Boston Retinal Implant Project initiated at the Massachusetts Institute of ...
Douglas B. Shire, Marcus D. Gingerich, Patricia I. Wong, Michael Skvarla, Stuart F. Cogan, Jinghua Chen, Wei Wang, Joseph F. Rizzo   +7 more
doaj   +1 more source

Photovoltaic retinal prosthesis with high pixel density

, 2012
Retinal degenerative diseases lead to blindness due to loss of the ‘image capturing’ photoreceptors, while neurons in the ‘image-processing’ inner retinal layers are relatively well preserved.
Theodore I. Kamins, Goetz, Georges, Richard Smith, Alexander Sher, Galambos, Ludwig, Harris, James S., Wang, Lele, James Loudin, Kamins, Theodore I., Keith Mathieson, Philip Huie, Georges Goetz, Loudin, James, Huie, Philip, Sher, Alexander, James S. Harris, Mathieson, Keith, Smith, Richard, Palanker, Daniel, Ludwig Galambos, Daniel Palanker, Lele Wang   +21 more
core   +3 more sources

Optogenetic approaches to retinal prosthesis [PDF]

Visual Neuroscience, 2014
AbstractThe concept of visual restoration via retinal prosthesis arguably started in 1992 with the discovery that some of the retinal cells were still intact in those with the retinitis pigmentosa disease. Two decades later, the first commercially available devices have the capability to allow users to identify basic shapes. Such devices are still very
Barrett John, Berlinguer-Palmini Rolando, Degenaar Patrick   +2 more
openaire   +3 more sources

Safety, effectiveness, and cost-effectiveness of Argus II in patients with retinitis pigmentosa: a systematic review [PDF]

International Journal of Ophthalmology, 2021
AIM: To assess the effectiveness, safety, and cost-effectiveness of the Argus II in treatment of the retinitis pigmentosa (RP) patients. METHODS: The ProQuest, Web of Science, EMBASE, MEDLINE (via PubMed) were searched using combinations of the keywords ...
Zakieh Ostad-Ahmadi, Amin Daemi, Mohammad-Reza Modabberi, Ali Mostafaie   +3 more
doaj   +1 more source

A REVIEW OF RETINAL PROSTHESIS APPROACHES [PDF]

International Journal of Modern Physics: Conference Series, 2012
Age-related macular degeneration and retinitis pigmentosa are two of the most common diseases that cause degeneration in the outer retina, which can lead to several visual impairments up to blindness. Vision restoration is an important goal for which several different research approaches are currently being pursued.
Kien, Tran, Maul, Tomas, Andrzej Bargiela   +2 more
openaire   +1 more source

A clinically viable approach to restoring visual function using optogenetic gene therapy

Molecular Therapy: Methods & Clinical Development, 2023
Optogenetic gene therapies offer a promising strategy for restoring vision to patients with retinal degenerative diseases, such as retinitis pigmentosa (RP). Several clinical trials have begun in this area using different vectors and optogenetic proteins
Boyuan Yan, Suresh Viswanathan, Scott E. Brodie, Wen-Tao Deng, Kirsten E. Coleman, William W. Hauswirth, Sheila Nirenberg   +6 more
doaj   +1 more source

Implantation of multiple suprachoroidal electrode arrays in rabbits

Journal of Current Ophthalmology, 2018
Purpose: Epiretinal and subretinal prosthesis have been shown to be a valid way to provide some vision to patients with advanced outer retinal degeneration and profound vision loss.
Walid Abdallah, Wen Li, James Weiland, Mark Humayun, Hossein Ameri   +4 more
doaj   +1 more source

Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation

Frontiers in Cellular Neuroscience, 2022
Retinal prostheses have shown some clinical success in patients with retinitis pigmentosa and age-related macular degeneration. However, even after the implantation of a retinal prosthesis, the patient’s visual acuity is at best less than 20/420. Reduced
Jungryul Ahn, Seongkwang Cha, Kwang-Eon Choi, Seong-Woo Kim, Yongseok Yoo, Yong Sook Goo   +5 more
doaj   +1 more source

Nanowire arrays restore vision in blind mice

Nature Communications, 2018
The restoration of light response using retinal prosthesis could be a way to restore vision following retinal degenerative disease. Here the authors develop gold-titania nanowire arrays that restore visual response in blind mice.
Jing Tang, Nan Qin, Yan Chong, Yupu Diao, Yiliguma, Zhexuan Wang, Tian Xue, Min Jiang, Jiayi Zhang, Gengfeng Zheng   +9 more
doaj   +1 more source

AnIn VitroModel of a Retinal Prosthesis [PDF]

IEEE Transactions on Biomedical Engineering, 2008
Epiretinal prostheses are being developed to bypass a degenerated photoreceptor layer and excite surviving ganglion and inner retinal cells. We used custom microfabricated multielectrode arrays with 200-microm-diameter stimulating electrodes and 10-microm-diameter recording electrodes to stimulate and record neural responses in isolated tiger ...
Ashish K. Ahuja, Matthew R. Behrend, Masako Kuroda, Mark S. Humayun, James D. Weiland   +4 more
openaire   +3 more sources