Results 101 to 110 of about 614,351 (314)

Profound Re-Organization of Cell Surface Proteome in Equine Retinal Pigment Epithelial Cells in Response to In Vitro Culturing [PDF]

, 2012
The purpose of this study was to characterize the cell surface proteome of native compared to cultured equine retinal pigment epithelium (RPE) cells. The RPE plays an essential role in visual function and represents the outer blood-retinal barrier.
Kerstin N. Euler, Ueffing, Marius, Fröhlich, K.J.H., Stefanie Hauck, Marius Ueffing, Euler, K.N., Fröhlich, Kristina J. H., Kerstin Euler, Claudia Alge-priglinger, Stefanie M. Hauck, Deeg, Cornelia A., Hauck, Stefanie M., Kristina J. H. Fröhlich, Euler, Kerstin N., Cornelia A. Deeg, Christoph Szober, Szober, Christoph M., Hauck, S.M., Ueffing, M., Kristina Fröhlich, Cornelia Deeg, Christoph M. Szober, Szober, C.M., Alge-Priglinger, C.S., Alge-Priglinger, Claudia, Deeg, C.A.   +25 more
core   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile

eLife
Retinal pigment epithelium (RPE) cells show heterogeneous levels of pigmentation when cultured in vitro. To know whether their color in appearance is correlated with the function of the RPE, we analyzed the color intensities of human-induced pluripotent ...
Yoko Nakai-Futatsugi, Jianshi Jin, Taisaku Ogawa, Noriko Sakai, Akiko Maeda, Ken-ichi Hironaka, Masakazu Fukuda, Hiroki Danno, Yuji Tanaka, Seiji Hori, Katsuyuki Shiroguchi, Masayo Takahashi   +11 more
doaj   +1 more source

Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa

Frontiers in Cell and Developmental Biology, 2020
Although an increasing number of disease genes have been identified, the exact cellular mechanisms of retinitis pigmentosa (RP) remain largely unclear. Retinal organoids (ROs) derived from the induced pluripotent stem cells (iPSCs) of patients provide a ...
Mei-Ling Gao, Mei-Ling Gao, Xin-Lan Lei, Xin-Lan Lei, Fang Han, Fang Han, Kai-Wen He, Kai-Wen He, Si-Qian Jin, Si-Qian Jin, You-You Zhang, You-You Zhang, Zi-Bing Jin, Zi-Bing Jin   +13 more
doaj   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Retinal regeneration and stem cell therapy in retinitis pigmentosa

Taiwan Journal of Ophthalmology, 2012
AbstractRetinitis pigmentosa (RP) is the leading cause of hereditary blindness, and there is currently no available treatment that can either significantly slow the progression of this disease or restore lost vision. Amphibians and birds exhibit different strategies for retinal regeneration, including the proliferation of cells in the ciliary margin ...
Kaplan, Henry J., Fernandez de Castro, Juan P.   +1 more
openaire   +1 more source

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

Reduction of all-trans-retinal limits regeneration of visual pigment in mice

, 1998
Absorption of photons by pigments in photoreceptor cells results in photoisomerization of the chromophore, 11-cis-retinal, to all-trans-retinal and activation of opsin.
Garwin, Gregory G, Palczewski, Krzysztof, Saari*,, John C, Van Hooser, J.Preston   +3 more
core   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source