Results 51 to 60 of about 614,351 (314)

Neural retina-specific Aldh1a1 controls dorsal choroidal vascular development via Sox9 expression in retinal pigment epithelial cells

eLife, 2018
VEGF secreted from retinal pigment epithelial (RPE) cells is responsible for the choroidal vascular development; however, the molecular regulatory mechanism is unclear.
So Goto, Akishi Onishi, Kazuyo Misaki, Shigenobu Yonemura, Sunao Sugita, Hiromi Ito, Yoko Ohigashi, Masatsugu Ema, Hirokazu Sakaguchi, Kohji Nishida, Masayo Takahashi   +10 more
doaj   +1 more source

Generation of Nonhuman Primate Model of Cone Dysfunction through In Situ AAV-Mediated CNGB3 Ablation

Molecular Therapy: Methods & Clinical Development, 2020
Summary: A major challenge to the development of therapies for human retinal degenerative diseases is the lack of an ideal preclinical model because of the physiological differences between humans and most model animals. Despite the successful generation
Qiang Lin, Ji-Neng Lv, Kun-Chao Wu, Chang-Jun Zhang, Qin Liu, Zi-Bing Jin   +5 more
doaj   +1 more source

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Targeting the Wnt Pathway and Transplantation Therapy as Strategies for Retinal Repair

Journal of Pharmacological Sciences, 2009
Recent advances in stem cell biology have provided new insights that may lead to the development of regeneration therapy in the central nervous system to replenish lost neurons and to reconstitute neural circuits.
Fumitaka Osakada, Masayo Takahashi
doaj   +1 more source

Critical Examination of Müller Glia-Derived in vivo Neurogenesis in the Mouse Retina

Frontiers in Cell and Developmental Biology, 2022
Müller glia (MG) are a potential source of stem cells in the mammalian retina that could replenish lost retinal neurons for vision restoration. Unlike their counterpart in zebrafish, mammalian MG are quiescent and they do not spontaneously generate new ...
Ye Xie, Bo Chen
doaj   +1 more source

Retinal Degeneration and Regeneration—Lessons From Fishes and Amphibians [PDF]

, 2017
International audienceRetinal degenerative diseases have immense socio-economic impact. Studying animal models that recapitulate human eye pathologies aids in understanding the pathogenesis of diseases and allows for the discovery of novel therapeutic ...
Muriel Perron, Ail, Divya, Divya Ail, Perron, Muriel   +3 more
core   +2 more sources

Retinitis Pigmentosa with EYS Mutations Is the Most Prevalent Inherited Retinal Dystrophy in Japanese Populations

Journal of Ophthalmology, 2015
The aim of this study was to gain information about disease prevalence and to identify the responsible genes for inherited retinal dystrophies (IRD) in Japanese populations. Clinical and molecular evaluations were performed on 349 patients with IRD.
Yuuki Arai, Akiko Maeda, Yasuhiko Hirami, Chie Ishigami, Shinji Kosugi, Michiko Mandai, Yasuo Kurimoto, Masayo Takahashi   +7 more
doaj   +1 more source

Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation

Stem Cell Reports, 2018
Summary: Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies.
Satoshi Iraha, Hung-Ya Tu, Suguru Yamasaki, Takahiro Kagawa, Motohito Goto, Riichi Takahashi, Takehito Watanabe, Sunao Sugita, Shigenobu Yonemura, Genshiro A. Sunagawa, Take Matsuyama, Momo Fujii, Atsushi Kuwahara, Akiyoshi Kishino, Naoshi Koide, Mototsugu Eiraku, Hidenobu Tanihara, Masayo Takahashi, Michiko Mandai   +18 more
doaj   +1 more source

OTX2 stimulates adult retinal ganglion cell regeneration

, 2022
Retinal ganglion cell (RGC) axons provide the only link between the light sensitive and photon transducing neural retina and visual centers of the brain.
Ibad, Raoul Torero, Nicole Quenech’du, Kenneth L Moya, Quenech’du, Nicole, Prochiantz, Alain, Raoul Torero Ibad, Alain Prochiantz, Moya, Kenneth, L, Ibad, Raoultorero, Moya, Kennethl, RaoulTorero Ibad, KennethL Moya   +11 more
core   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury

Neural Regeneration Research, 2023
Ras homolog enriched in brain (Rheb) is a small GTPase that activates mammalian target of rapamycin complex 1 (mTORC1). Previous studies have shown that constitutively active Rheb can enhance the regeneration of sensory axons after spinal cord injury by ...
Jikuan Jiang, Lusi Zhang, Jingling Zou, Jingyuan Liu, Jia Yang, Qian Jiang, Peiyun Duan, Bing Jiang   +7 more
doaj   +1 more source