Results 31 to 40 of about 614,351 (314)

On the Generation and Regeneration of Retinal Ganglion Cells [PDF]

Frontiers in Cell and Developmental Biology, 2020
Retinal development follows a conserved neurogenic program in vertebrates to orchestrate the generation of specific cell types from multipotent progenitors in sequential but overlapping waves. In this program, retinal ganglion cells (RGCs) are the first cell type generated.
Viviane M. Oliveira-Valença, Alejandra Bosco, Monica L. Vetter, Mariana S. Silveira, Mariana S. Silveira   +4 more
openaire   +4 more sources

Correction to: Therapeutic Effects of Combination Therapy and Photobiomodulation Therapy on Retinal Regeneration [PDF]

J Lasers Med Sci
Behnaz Ahrabi, Samareh Omidvari, Shamim Mollazadeh Ghomi, Navid Ahmady Roozbahany, Saeed Vafaei‐Nezhad, Atefeh Shirazi Tehrani, Hojjat‐Allah Abbaszadeh, Shahram Darabi   +7 more
openalex   +3 more sources

Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells [PDF]

, 2012
Recombinant adeno-associated viral (rAAV) vectors can be used to introduce neurotrophic genes into injured CNS neurons, promoting survival and axonal regeneration.
Rodger Jennifer, Hellström Mats, Alan R Harvey, Jennifer Rodger, Mats Hellström, Hellström, M., Robertson, D., Harvey, A.R., Donald Robertson, Drummond Eleanor S., Harvey Alan R., Eleanor S Drummond, Rodger, J., Drummond, E.S., Robertson Donald   +14 more
core   +2 more sources

Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application

Stem Cell Reports, 2014
Age-related macular degeneration (AMD) causes severe visual impairment due in part to age-dependent impairment of retinal pigment epithelium (RPE). It has been suggested that autologous human induced pluripotent stem cells (hiPSCs) may represent a useful
Hiroyuki Kamao, Michiko Mandai, Satoshi Okamoto, Noriko Sakai, Akiko Suga, Sunao Sugita, Junichi Kiryu, Masayo Takahashi   +7 more
doaj   +1 more source

Quantitative and Qualitative Evaluation of Photoreceptor Synapses in Developing, Degenerating and Regenerating Retinas

Frontiers in Cellular Neuroscience, 2019
Quantitative and qualitative evaluation of synapses is crucial to understand neural connectivity. This is particularly relevant now, in view of the recent advances in regenerative biology and medicine.
Ryutaro Akiba, Ryutaro Akiba, Take Matsuyama, Hung-Ya Tu, Tomoyo Hashiguchi, Junki Sho, Shuichi Yamamoto, Masayo Takahashi, Michiko Mandai   +8 more
doaj   +1 more source

Chemically-induced photoreceptor degeneration and protection in mouse iPSC-derived three-dimensional retinal organoids

Stem Cell Research, 2017
Induced pluripotent stem cells (iPSCs), which can be differentiated into various tissues and cell types, have been used for clinical research and disease modeling.
Shin-ichiro Ito, Akishi Onishi, Masayo Takahashi   +2 more
doaj   +1 more source

Is the Capacity for Optic Nerve Regeneration Related to Continued Retinal Ganglion Cell Production in the Frog? [PDF]

, 1989
In the central nervous system of fish and frogs, some, but not all, axons can regenerate. Retinal ganglion cells are among those that can. The retinae of fish and frogs produce new retinal neurons, including ganglion cells, for months or years after ...
Jack, J. L., Easter, Stephen S., Taylor, J. S. H.   +2 more
core   +1 more source

Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice

Stem Cell Reports, 2014
In this article, we show that mouse embryonic stem cell- or induced pluripotent stem cell-derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner and outer segments even in an advanced retinal degeneration model ...
Juthaporn Assawachananont, Michiko Mandai, Satoshi Okamoto, Chikako Yamada, Mototsugu Eiraku, Shigenobu Yonemura, Yoshiki Sasai, Masayo Takahashi   +7 more
doaj   +1 more source

Integrative transcription start site analysis and physiological phenotyping reveal torpor-specific expression program in mouse skeletal muscle

Communications Biology, 2021
Ruslan Deviatiiarov et al. identify torpor-specific promoters with an enriched binding motif and the transcription factor ATF3 highly expressed during torpor deprivation.
Ruslan Deviatiiarov, Kiyomi Ishikawa, Guzel Gazizova, Takaya Abe, Hiroshi Kiyonari, Masayo Takahashi, Oleg Gusev, Genshiro A. Sunagawa   +7 more
doaj   +1 more source

Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture

Regenerative Therapy, 2022
Background: The BMP signaling pathway plays a key role in growth, differentiation and patterning during neural development. Recent work on the generation of a self-organization of three-dimensional retinal organoid (3D-retina) from human pluripotent stem
Suguru Yamasaki, Atsushi Kuwahara, Akiyoshi Kishino, Toru Kimura, Masayo Takahashi, Michiko Mandai   +5 more
doaj   +1 more source