Results 11 to 20 of about 614,351 (314)
Cellular and Molecular Triggers of Retinal Regeneration in Amphibians [PDF]
Life, 2023 Understanding the mechanisms triggering the initiation of retinal regeneration in amphibians may advance the quest for prevention and treatment options for degenerating human retina diseases.
Yuliya V. Markitantova +1 more
doaj +3 more sources
An In-Silico Study on the Most Effective Growth Factors in Retinal Regeneration Utilizing Tissue Engineering Concepts [PDF]
Journal of Ophthalmic & Vision Research, 2021 Purpose: Considering the significance of retinal disorders and the growing need to employ tissue engineering in this field, in-silico studies can be used to establish a cost-effective method.
Nima Beheshtizadeh +3 more
doaj +3 more sources
The neuroimmune interface in retinal regeneration [PDF]
Progress in Retinal and Eye ResearchRetinal neurodegeneration leads to irreversible blindness due to the mammalian nervous system's inability to regenerate lost neurons. Efforts to regenerate retina involve two main strategies: stimulating endogenous cells to reprogram into neurons or transplanting stem-cell derived neurons into the degenerated retina.
Sucheta Bhattacharya +3 more
openaire +4 more sources
Nanotherapy for Neural Retinal Regeneration [PDF]
Advanced ScienceAbstract Retinal diseases can severely impair vision and even lead to blindness, posing significant threats to both physical and mental health. Physical retinal regenerative therapies are poised to revolutionize the treatment of various disorders associated with blindness. However, these therapies must overcome the challenges posed by
Chuyao Yu +11 more
openaire +4 more sources
Inhibition of the TGFβ Pathway Enhances Retinal Regeneration in Adult Zebrafish. [PDF]
PLoS ONE, 2016 In contrast to the mammalian retina, the zebrafish retina exhibits the potential for lifelong retinal neurogenesis and regeneration even after severe damage. Previous studies have shown that the transforming growth factor beta (TGFβ) signaling pathway is
Christoph Tappeiner +5 more
doaj +4 more sources
Recapitulating developmental mechanisms for retinal regeneration [PDF]
Progress in Retinal and Eye Research, 2020 Degeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes.
Ahmad, Iqbal +3 more
openaire +3 more sources
Retinal regeneration requires dynamic Notch signaling [PDF]
Neural Regeneration Research, 2022 Retinal damage in the adult zebrafish induces Müller glia reprogramming to produce neuronal progenitor cells that proliferate and differentiate into retinal neurons. Notch signaling, which is a fundamental mechanism known to drive cell-cell communication, is required to maintain Müller glia in a quiescent state in the undamaged retina, and repression ...
Leah J Campbell +3 more
openaire +4 more sources
Live-cell imaging: new avenues to investigate retinal regeneration [PDF]
Neural Regen Res, 2017 Sensing and responding to our environment requires functional neurons that act in concert. Neuronal cell loss resulting from degenerative diseases cannot be replaced in humans, causing a functional impairment to integrate and/or respond to sensory cues ...
Manuela Lahne, David R Hyde, DavidR Hyde
core +2 more sources
A transcriptome for the study of early processes of retinal regeneration in the adult newt, Cynops pyrrhogaster. [PDF]
PLoS ONE, 2014 Retinal regeneration in the adult newt is a useful system to uncover essential mechanisms underlying the regeneration of body parts of this animal as well as to find clues to treat retinal disorders such as proliferative vitreoretinopathy.
Kenta Nakamura +8 more
doaj +2 more sources
Leveraging Zebrafish to Study Retinal Degenerations [PDF]
Frontiers in Cell and Developmental Biology, 2018 Retinal degenerations are a heterogeneous group of diseases characterized by death of photoreceptors and progressive loss of vision. Retinal degenerations are a major cause of blindness in developed countries (Bourne et al., 2017; De Bode, 2017) and ...
Juan M. Angueyra, Katie S. Kindt
doaj +2 more sources