Results 41 to 50 of about 614,351 (314)
, 2014 Retinal degenerative diseases, e.g. retinitis pigmentosa, with resulting photoreceptor damage account for the majority of vision loss in the industrial world. Animal models are of pivotal importance to study such diseases.
Maurer, Ellinor +5 more
core +2 more sources
Lentiviral Vectors for Ocular Gene Therapy
Pharmaceutics, 2022 This review offers the basics of lentiviral vector technologies, their advantages and pitfalls, and an overview of their use in the field of ophthalmology.
Yvan Arsenijevic +3 more
doaj +1 more source
Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish. [PDF]
, 2017 A fascinating difference between teleost and mammals is the lifelong potential of the teleost retina for retinal neurogenesis and regeneration after severe damage.
Arendt, Petra +9 more
core +1 more source
Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody
Arthritis Research & Therapy, 2017 Background A novel anti-mouse CD3ε antibody, Dow2, recognizes mouse CD3ε without activating T cells and suppresses T-cell activation. The purpose of this study was to determine whether Dow2 can inhibit T cells in uveitis.
Sunao Sugita +5 more
doaj +1 more source
Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons [PDF]
, 2014 This work was supported by the Medical Research Council, the Christopher and Dana Reeve Foundation, the John and Lucille van Geest Foundation, the Henry Smith Charity, the Commonwealth and Overseas scholarships, and the Hinduja Cambridge Trust.PNS axons ...
Cheah, Menghon +7 more
core +1 more source
Cell Transplantation, 2010 Using the mouse ES cell line with green fluorescent protein knocked-in at the Rx locus (Rx-KI ES cell), we previously showed that photoreceptors can be efficiently obtained in defined culture conditions by enriching Rx-positive retinal progenitor cells ...
Michiko Mandai +5 more
doaj +1 more source
A microRNA for retinal regeneration [PDF]
Science, 2014 Retinal Regeneration![Figure][1] Glia cell progenitors (cyan) divide after retina damage CREDIT: K. RAJARAM ET AL., DEVELOPMENTAL BIOLOGY 392 , 393 © ELSEVIER LIMITED Damage to the retina causes blindness in humans but not in zebrafish. Muller glia, a cell type shared by both mammals and zebrafish, helps zebrafish retinas regenerate. Rajaram et al.
openaire +1 more source
Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract
Experimental and Molecular Medicine, 2018 Hereditary eye disease: Looking for blindness in the family tree In-depth genomic analysis of the family of a young man with severe visual impairment reveals a new gene involved in eye development. Ocular coloboma encompasses various hereditary disorders
Xiu-Feng Huang +13 more
doaj +1 more source
Stem Cell Reports, 2016 There is an ongoing controversy as to whether major histocompatibility complex (MHC) matching is a solution for allogeneic stem cell transplantation. In the present study, we established retinal pigment epithelial (RPE) cells from induced pluripotent ...
Sunao Sugita +9 more
doaj +1 more source
Adult limbal neurosphere cells: a potential autologous cell resource for retinal cell generation [PDF]
, 2014 The Corneal limbus is a readily accessible region at the front of the eye, separating the cornea and sclera. Neural colonies (neurospheres) can be generated from adult corneal limbus in vitro.
Jessica Cooke (637632) +23 more
core +1 more source