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Nano-Biomaterials for Retinal Regeneration [PDF]
Nanomaterials, 2021 Nanoscience and nanotechnology have revolutionized key areas of environmental sciences, including biological and physical sciences. Nanoscience is useful in interconnecting these sciences to find new hybrid avenues targeted at improving daily life.
Nikhlesh Singh +2 more
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Trends in Neurosciences, 1992 The goal of research on neural regeneration is to restore brain function following injury. To many, this suggests regrowing damaged axons and re-establishing the interrupted pathways. A second, but little studied aspect of brain regeneration, is the replacement of lost neurons.
Hitchcock, Peter F., Raymond, Pamela A.
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The Retinal Homeobox (Rx) Gene Is Necessary for Retinal Regeneration
Developmental Biology, 2011 The Retinal Homeobox (Rx) gene is essential for vertebrate eye development. Rx function is required for the specification and maintenance of retinal progenitor cells (RPCs). Loss of Rx function leads to a lack of eye development in a variety of species. Here we show that Rx function is also necessary during retinal regeneration. We performed a thorough
Heithem M El-Hodiri, Lisa E Kelly
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Activated retinal glia mediated axon regeneration in experimental glaucoma
Neurobiology of Disease, 2012 Glaucoma, a leading cause of blindness, is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons in the optic nerve and their cell bodies in the retina.
Barbara Lorber +3 more
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iScience, 2021 Summary: ESC/iPSC-retinal sheet transplantation, which supplies photoreceptors as well as other retinal cells, has been shown to be able to restore visual function in mice with end-stage retinal degeneration.
Take Matsuyama +9 more
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Scientific Reports, 2021 Several clinical studies have been conducted into the practicality and safety of regenerative therapy using hESC/iPSC-retinal pigment epithelium (RPE) as a treatment for the diseases including age-related macular degeneration.
Mitsuhiro Nishida +11 more
doaj +1 more source
Retinal regeneration in birds and mice [PDF]
Current Opinion in Genetics & Development, 2016 Retinal regeneration from resident Müller glia cells is robust in teleost fish, but is severely limited in birds and mammals. After neurotoxic injury, chick Müller glia can proliferate, and activate neurogenic genes, but they display limited capacity to differentiate into neurons. Developmental signaling molecules enhance this process.
Matthew S, Wilken, Thomas A, Reh
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Scientific Reports, 2020 In patients with retinitis pigmentosa (RP), color fundus photography and fundus autofluorescence (FAF) have been used to estimate the disease progression.
Kenichi Makabe +4 more
doaj +1 more source
iScience, 2022 Summary: Pluripotent stem cell (PSC)-derived retinal sheet transplanted in vivo can form structured photoreceptor layers, contact with host bipolar cells, and transmit light signals to host retinas.
Suguru Yamasaki +10 more
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Stem Cell Research & Therapy, 2020 Background Significant progress has been made in cell replacement therapy for neural retinal diseases using retinal cells differentiated from human pluripotent stem cells.
Deng Pan +7 more
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