Results 81 to 90 of about 137,312 (290)

Combining Fine- and Coarse-Grained Classifiers for Diabetic Retinopathy Detection

, 2020
Visual artefacts of early diabetic retinopathy in retinal fundus images are usually small in size, inconspicuous, and scattered all over retina. Detecting diabetic retinopathy requires physicians to look at the whole image and fixate on some specific ...
Adrià Recasens, DY Carson Lam, E Decencière, G Quellec, J Amin, L Seoud, MD Abràmoff, MU Akram, N Ramachandran, P Costa, R Welikala, V Gulshan, Z Wang, Ze Yang   +13 more
core   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Retinal vessel segmentation using Gabor Filter and Textons [PDF]

, 2014
This paper presents a retinal vessel segmentation method that is inspired by the human visual system and uses a Gabor filter bank. Machine learning is used to optimize the filter parameters for retinal vessel extraction.
Fisher, Mark, Wang, Wenjia, Zhang, Lei
core  

Glaucomatous vertical vessel density asymmetry of the temporal raphe detected with optical coherence tomography angiography. [PDF]

, 2020
Changes in retinal vasculature and ocular circulation may play an important role in the glaucoma development and progression. We evaluated the vertical asymmetry across the temporal raphe of the deep retinal layer vessel density, using swept-source ...
Araie, Makoto, Ibuki, Hisashi, Kanno, Junji, Shinoda, Kei, Shoji, Takuhei, Weinreb, Robert N, Yoshikawa, Yuji   +6 more
core  

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Characterization of retinal vessels by fractal analysis: its importance in pathology

Applied Medical Informatics, 2019
The retinal circulation is the only part of human circulation that can be directly observed by ophthalmosopy. By this assessment, a lot of connection between the appearances of retinal microcirculation has been already established.
Adriana Elena BULBOACĂ, Valeriu BUT, Dinu BOLUNDUŢ, Alexandra BULBOACĂ, Sorana D. BOLBOACĂ   +4 more
doaj  

Monitoring the Patient with Retinal Angiopathy Associated with Hereditary Transthyretin Amyloidosis: Current Perspectives

Clinical Ophthalmology, 2022
João Heitor Marques,1 João Coelho,1 Maria João Menéres,1,2 João Melo Beirão1,2 1Serviço de Oftalmologia, Centro Hospitalar Universitário do Porto, Porto, Portugal; 2Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto ...
Marques JH, Coelho J, Menéres MJ, Melo Beirão J   +3 more
doaj  

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source