Results 131 to 140 of about 68,477 (247)

Comparison of Diagnostic Utilities in a Canine Retrobulbar Large B‐Cell Lymphoma With Multifocal Involvement

open access: yesVeterinary Medicine and Science, Volume 12, Issue 1, January 2026.
This case details a rare retrobulbar lymphoma with multifocal involvement. Diagnostic modalities included MRI/CT, cytology of various sites, immunophenotyping and PARR. These tests confirmed diverse cellular populations and Ig clonality across affected tissues. ABSTRACT Lymphoma is the most common malignant neoplasm in dogs.
Rankyung Jung   +4 more
wiley   +1 more source

Risk definition and management strategies in retinoblastoma: current perspectives

open access: yesClinical Ophthalmology, 2015
Fariba Ghassemi, Alireza Khodabande Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Tehran Province, Islamic Republic of Iran Abstract: This manuscript focuses on high-risk factors of metastatic disease in ...
Ghassemi F, Khodabande A
doaj  

Genomic Perspective on Heterogeneity of Organs and Body Aging

open access: yesAging Cell, Volume 25, Issue 1, January 2026.
Organ‐specific and whole‐body intrinsic aging metrics reveal heterogeneous organ aging, which potentially can arise from the interplay between static germline variation, somatic mutations, epigenetic drift, transposable elements, and mitochondrial DNA changes, highlighting genomic pathways for precision, organ‐targeted aging interventions.
Shabnam Salimi   +2 more
wiley   +1 more source

Cellular Senescence, Inflammaging and Cardiovascular Disease

open access: yesImmunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Aging is the most important yet unmodifiable risk factor for cardiovascular disease (CVD). As a result, targeting cardiovascular aging has emerged as a promising strategy to promote long‐term cardiovascular health. This review summarizes current knowledge on the effects of aging within the cardiovascular system as well as systemic processes ...
Lukas Zanders   +3 more
wiley   +1 more source

SWI/SNF Chromatin Remodelling Complex in Hepatic Physiology: Mechanistic Insights Into Development, Homeostasis and Pathogenesis

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT The liver executes essential metabolic functions including energy homeostasis, lipid biosynthesis, cholesterol regulation and xenobiotic detoxification. While hepatocyte metabolic activity forms the foundation of these processes, their precise regulation is achieved through chromatin remodelling mechanisms, with the SWI/SNF complex emerging as
Rui Li   +4 more
wiley   +1 more source

Molecular Insights and Therapeutic Innovations in Cervical Cancer: Emerging Drug Targets

open access: yesAdvances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Cervical cancer is a significant global health challenge, ranking as the fourth most prevalent cancer among women worldwide. While human papillomavirus infection is the primary cause, the disease’s progression involves complex molecular mechanisms.
Abhijit Debnath   +6 more
wiley   +1 more source

Severe Hypercalcemia and Confusion in a Middle‐Aged Male: The Hidden Diagnosis of Parathyroid Carcinoma

open access: yesCase Reports in Endocrinology, Volume 2026, Issue 1, 2026.
Parathyroid cancer (PC) is one of the rarest causes of primary hyperparathyroidism (PHPT), typically exhibiting an indolent course but presenting with more severe symptoms compared to its benign counterparts. The diagnosis is most often made postoperatively through histopathological examination; however, certain clinical and biochemical features may ...
Helena Fahmi   +5 more
wiley   +1 more source

Personalizing therapies over the course of hormone receptor‐positive/HER2‐negative metastatic breast cancer

open access: yesCA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.
ABSTRACT The hormone receptor (HR)‐positive/human epidermal growth factor receptor 2 (HER2)‐negative breast cancer subtype accounts for most early and metastatic breast cancer (MBC) cases. HR‐positive/HER2‐negative MBC is characterized by a relatively prolonged, although variable, disease course and substantial intertumoral and intratumoral ...
Akshara Singareeka Raghavendra   +5 more
wiley   +1 more source

Targeting MCM6 Enhances Melphalan Chemosensitivity in Retinoblastoma by Modulating DNA Damage Response. [PDF]

open access: yesInvest Ophthalmol Vis Sci
Wang M   +12 more
europepmc   +1 more source

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