Central Serous Chorioretinopathy in a Case of Regressed Familial Retinoblastoma
Journal of Ophthalmic & Vision Research, 2020 Purpose: To present a case of central serous chorioretinopathy (CSC) in association with regressed familial retinoblastoma. Case Report: A 23-year-old man with regressed unilateral familial retinoblastoma in his left eye presented with decreased ...
Saeed Karimi +3 more
doaj +1 more source
Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer. [PDF]
, 2018 Purpose: The retinoblastoma tumor suppressor (RB), a key regulator of cell-cycle progression and proliferation, is functionally suppressed in up to 50% of non-small cell lung cancer (NSCLC).
Addya, Sankar +14 more
core +1 more source
Late Mortality Among Survivors of Childhood Cancer in Canada: A Retrospective Cohort Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with cancer face an increased risk of complications and death beyond the 5‐year survival mark. National surveillance efforts facilitate the systematic tracking of long‐term health outcomes, including treatment‐related complications and late mortality, among childhood cancer survivors.
Katherine McKenzie +5 more
wiley +1 more source
Retinoblastoma in Adults: a Case Report and Literature Review
Journal of Ophthalmic & Vision Research, 2014 Purpose: To report a case of adult retinoblastoma with a wrong diagnosis of melanoma. Case report: Herein, we present an adult retinoblastoma case who was misdiagnosed as melanoma in fine-needle aspiration biopsy with intravitreal hemorrhage and later ...
Mehdi Sharifzadeh +4 more
doaj +1 more source
The insulin-RB synapse in health and disease: cellular rocket science [PDF]
arXiv, 2007 Time has come for a survey of our knowledge on the physical interaction between the growth-promoting insulin molecule and retinoblastoma tumor suppressor protein (RB). Theoretical and experimental observations over the past 15 years reviewed here indicate that the insulin-RB dimer may represent an essential molecular crossroads involved in major ...
arxiv
LncRNA HOTAIR/miR‐613/c‐met axis modulated epithelial‐mesenchymal transition of retinoblastoma cells
Journal of Cellular and Molecular Medicine, 2018 Since lncRNAs could modulate neoplastic development by modulating downstream miRNAs and genes, this study was carried out to figure out the synthetic contribution of HOTAIR, miR‐613 and c‐met to viability, apoptosis and proliferation of retinoblastoma ...
Ge Yang +5 more
semanticscholar +1 more source
Twenty Years of the Paediatric Radiation Oncology Society
Pediatric Blood &Cancer, EarlyView.ABSTRACT In 2005, the Paediatric Radiation Oncology Society (PROS), a multi‐professional association to promote radiotherapy for children and young people, was created. Its mission has been to educate those involved in this field, and to improve the standards of radiation oncology care for children, adolescents, and young adults across the globe, not ...
Mark N. Gaze +18 more
wiley +1 more source
Cell-permeable tumor suppressor peptides for cancer therapy: back to the future [PDF]
arXiv, 2007 Miniaturization is a hallmark of modern technologies. Notably, this feature has not spared molecular biology and its potential applications. Towards developing more effective therapeutics against cancer, studies began to explore more than a decade ago how natural tumor suppression could be translated into antineoplastic drugs.
arxiv
Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. [PDF]
, 2019 The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by ...
Cristea, Sandra +8 more
core