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Retinoblastoma protein and the cell cycle
Current Opinion in Genetics & Development, 1993Deregulation of the cell cycle may contribute one of the primary mechanisms through which cancer arises. Eukaryotic cell division has been found to be a strictly controlled process, involving response to both positive and negative external signals and assessment of the cell's internal state.
R E, Hollingsworth +2 more
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Retinoid-binding proteins in retinoblastoma cells
1990A combination of Western blot, Northern blot, and radiolabeled ligand-binding techniques was used to investigate retinoid-binding proteins in retinoblastoma (RB) cells from fresh tumors and from 19 RB tumor lines cultured in vitro . Using rabbit anti-bovine cellular retinal-binding protein (CRA1BP) antibodies, no CRA1BP could be detected. As determined
S L, Fong, C D, Bridges
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The retinoblastoma protein and its relatives
Seminars in Cancer Biology, 1995The retinoblastoma tumor suppressor gene is inactivated in retinoblastomas and a variety of other tumor types. In addition, it is one of several cellular proteins targeted by the transforming proteins of the small DNA tumor viruses. At least two other cellular proteins that are targeted by the viral transforming proteins are structurally and ...
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Immunohistochemical Detection of the Retinoblastoma Protein
2018The retinoblastoma protein (pRB) plays a key role in proliferative control and genome stability. For these reasons its functions are considered to be tumor suppressive. Its functional status offers critical insight into proliferative control signaling in tissues and in developing malignancies.
Charles A, Ishak +3 more
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Transcriptional regulation by the retinoblastoma protein
Trends in Cell Biology, 1993The retinoblastoma protein (RB) plays a key role in the control of cell proliferation and mediates the terminal differentiation of certain cell types. Increasing evidence suggests that RB functions by contacting and modifying the behaviour of transcription factors.
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Transcriptional control by the retinoblastoma protein
Seminars in Cancer Biology, 1995The retinoblastoma gene product is an abundant nuclear protein whose 'pocket domain' mediates numerous protein-protein interactions. A substantial proportion of the RB-interacting proteins are transcription factors suggesting that RB plays a fundamental role in the regulation of transcription.
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[Histone deacetylase and retinoblastoma protein].
Bulletin du cancer, 1998The balance between cellular proliferation and differentiation is strictly controlled in the cell and the deregulation of this balance can lead to tumour formation. The tumour suppressor protein Rb plays a key role in this balance essentially by repressing progression through the cell cycle and thereby it blocks the cell in G1 phase.
L, Magnaghi-Jaulin +5 more
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly
The protein corona from nanomedicine to environmental science
Nature Reviews Materials, 2023Assist Prof Morteza Mahmoudi +2 more
exaly