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Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System.

Annual Review of Immunology, 2016
Vitamin A is a multifunctional vitamin implicated in a wide range of biological processes. Its control over the immune system and functions are perhaps the most pleiotropic not only for development but also for the functional fate of almost every cell ...
Alexandre Larangé, H. Cheroutre
semanticscholar   +3 more sources

Evolution of retinoic acid receptors and retinoic acid signaling.

Sub-cellular biochemistry, 2014
Retinoic acid (RA) is a vitamin A-derived morphogen controlling important developmental processes in vertebrates, and more generally in chordates, including axial patterning and tissue formation and differentiation. In the embryo, endogenous RA levels are controlled by RA synthesizing and degrading enzymes and the RA signal is transduced by two ...
Juliana Gutierrez-Mazariegos   +2 more
semanticscholar   +5 more sources

The interplay between retinoic acid binding proteins and retinoic acid degrading enzymes in modulating retinoic acid concentrations.

Current Topics in Developmental Biology
The active metabolite of vitamin A, all-trans-retinoic acid (atRA), is critical for maintenance of many cellular processes. Although the enzymes that can synthesize and clear atRA in mammals have been identified, their tissue and cell-type specific roles are still not fully established.
N. Isoherranen, Y. Wen
semanticscholar   +3 more sources

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