Results 301 to 310 of about 5,117,644 (334)

Study of retinoic acid polymorphism

Journal of Pharmaceutical Sciences, 2006
Some authors recently hypothesized the existence of a new retinoic acid (RA) phase in addition to the two already known polymorphs. We investigated RA polymorphism and our results exclude the presence of new modifications and refine the properties of the known forms.
CAVIGLIOLI, GABRIELE, PANI, MARCELLA, GATTI, PIERLUIGI, PARODI, BRUNELLA, CAFAGGI, SERGIO, BIGNARDI, GAETANO   +5 more
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Retinoic Acid for Psoriasis

Australasian Journal of Dermatology, 1972
SUMMARY This study was undertaken to ascertain whether Retinoic Acid is of clinical use in the treatment of psoriasis and further, to compare its efficacy with an acknowledged successful method of treatment, i.e. the modified Leeds regime.
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Retinoic Acid Receptor Alpha Amplifications and Retinoic Acid Sensitivity in Breast Cancers

Clinical Breast Cancer, 2013
Molecular segmentation of breast cancer allows identification of small groups of patients who present high sensitivity to targeted agents. A patient, with chemo- and trastuzumab-resistant HER2-overexpressing breast cancer, who presented concomitant acute promyelocytic leukemia, showed a response in her breast lesions to retinoic acid, arsenic, and ...
S. Alsafadi, C. Even, C. Falet, A. Goubar, F. Commo, V. Scott, V. Quidville, L. Albiges, DIECI, MARIA VITTORIA, J. Guegan, V. Lazar, J. C. Ahomadegbe, S. Delaloge, F. André   +13 more
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Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

Nature, 1990
Retinoic acid, the first morphogen described so far in vertebrates, is a vitamin A derivative which exerts striking effects on development and differentiation. The identification of three retinoic acid receptors as members of the nuclear receptor super-family provides an explantation for the molecular action of morphogens on gene expression. Functional
de Thé, Hugues, del Mar Vivanco-Ruiz, Maria, Tiollais, Pierre, Stunnenberg, Henk, Dejean, Anne   +4 more
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Retinoic Acid

Encyclopedia of Molecular Pharmacology, 2021

semanticscholar   +1 more source

History of Retinoic Acid Receptors

2014
The discovery of retinoic acid receptors arose from research into how vitamins are essential for life. Early studies indicated that Vitamin A was metabolized into an active factor, retinoic acid (RA), which regulates RNA and protein expression in cells.
Cécile Rochette-Egly, Pierre Chambon, Doris M. Benbrook, Mary Ann Asson-Batres   +3 more
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The Retinoic Acid Receptors [PDF]

, 2015
Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
Hugues de Th�, Anne Dejean
openaire   +1 more source

Retinoic Acid Receptors in Hematopoiesis

1996
Retinoic acid receptors (RARs) are critical transcriptional regulators that are involved in the development and differentiation of a wide variety of different cells (Evans 1988). Several lines of evidence suggest that RARs may be involved in the regulation of hematopoiesis.
Irwin D. Bernstein, Schickwann Tsai, Steven J. Collins   +2 more
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The Regulation of Retinoic Acid Formation

Nutrition Reviews, 2009
Rat liver microsomal as well as cytosolic retinol dehydrogenases from cellular retinal-binding protein (CRBP)-retinal from CRBP-retinol. A cytosolic dehydrogenase transforms retinal into retinoic acid. Apo-CRBP and ethanol inhibit the cytosolic but not the microsomal retinol dehydrogenase, the latter being the primary enzyme in the rate-limiting step ...
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Retinoic Acid, All-trans Retinoic Acid (ATRA), and Tamibarotene

2017
Retinoids, all-trans retinoic acid (ATRA), and tamibarotene can induce differentiation of leukemic cells that carry t(15;17) and potentially lead to complete remission (CR) in patients with acute promyelocytic leukemia (APL). Although introduction of ATRA as a differentiating agent has been a major breakthrough in the treatment of APL, ATRA is ...
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