Results 101 to 110 of about 390,951 (380)

Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)

Nuclear Receptor Signaling, 2009
Nuclear retinoic acid receptors (RARs) are transcriptional regulators controlling the expression of specific subsets of genes in a ligand-dependent manner. The basic mechanism for switching on transcription of cognate target genes involves RAR binding at
C. Rochette-Egly, P. Germain
semanticscholar   +1 more source

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion [PDF]

, 2016
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer ...
Attwood, S, Auernheimer, V, Chronopoulos, A, Cortes, E, Del Rio Hernandez, AE, Fabry, B, Garcia, R, Ghassemi, S, Lachowski, D, Robinson, B, Sarper, M   +10 more
core   +1 more source

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells

Journal of Lipid Research, 2004
An acidic phospholipase A2 (LPLA2) was recently purified and cloned. THP-1 cells were used to characterize the gene induction of LPLA2. THP-1 cells were stimulated with several differentiation agents.
Akira Abe, Heather K. Poucher, Miki Hiraoka, James A. Shayman   +3 more
doaj  

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin

Translational Oncology, 2021
Despite advances in personalised medicine and the emerging role of immune checkpoints in directing treatment decisions in subsets of lung cancer patients, non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related deaths worldwide.
Lauren MacDonagh, Rhyla Mae Santiago, Steven G. Gray, Eamon Breen, Sinead Cuffe, Stephen P. Finn, Kenneth J. O'Byrne, Martin P. Barr   +7 more
doaj  

Retinoic Acid-Mediated Gene Expression in Transgenic Reporter Zebrafish [PDF]

, 2001
Retinoic acid-mediated gene activation is important for normal vertebrate development. The size and nature of retinoic acid make it difficult to identify the precise cellular location of this signaling molecule throughout an embryo.
Hardison, Nancy L., Linney, Elwood, Perz-Edwards, Alyssa   +2 more
core   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Біохімічні аспекти сигнальної функції ретиноїдів при регенерації печінки [PDF]

, 2013
Дослiджено роль рецепторiв ретиноєвої кислоти та канонiчної сигналiзацiї ретиноїдiв у регенерацiї печiнки. З використанням моделi клiтинно-специфiчної абляцiї рецепторiв ретиноєвої кислоти шляхом активацiї домiнантної негативної iзоформи (RARαDN ...
Бленер, В.С., Марченко, М.М., Морозевич, Ю.Д., Шмараков, І.О.   +3 more
core  

Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity

Advanced Science, EarlyView.
This study uncovers a spatiotemporal regulation of STING activity by linear ubiquitination in antiviral immunity. At the early stage of the infection, LUBAC promotes STING linear ubiquitination to drive its trafficking from the ER to the Golgi apparatus for activation.
Yong Zhang, Yesheng Fu, Lihua Qiang, Mengyuan Zhao, Zhe Lu, Zhuo Zhao, Guoping Chen, Zehui Lei, Qiyao Chai, Pupu Ge, Bingxi Li, Jing Wang, Cui Hua Liu, Lingqiang Zhang   +13 more
wiley   +1 more source