Results 111 to 120 of about 349,317 (300)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR. [PDF]

Nucleic Acids Res, 2020
Osz J, McEwen AG, Bourguet M, Przybilla F, Peluso-Iltis C, Poussin-Courmontagne P, Mély Y, Cianférani S, Jeffries CM, Svergun DI, Rochel N.   +10 more
europepmc   +1 more source

Chronic ethanol administration enhances retinoic acid and triiodothyronine receptor expression in mouse liver [PDF]

, 1993
Véronique Pallet, M. Coustaut, F. Naulet, D. Higueret, H Garcin, Paul Higueret   +5 more
openalex   +1 more source

Retinoic acids and nuclear receptor signaling in liver development: Pathogenic roles in liver diseases

Pediatric Discovery
Retinoic acid (RA) serves as a metabolic intermediate of vitamin A. It plays a crucial physiological role in regulating cell proliferation, differentiation, apoptosis, embryonic development, and immunomodulation.
Wen Jia, Yang Bi
doaj   +1 more source

Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL‐286, a novel retinoic acid receptor‐β agonist for treatment of spinal cord injury, in male healthy participants [PDF]

, 2023
Maria B. Goncalves, Tim Mant, Jörg Täubel, Earl E. Clarke, Hana Hassanin, Daryl Bendel, Henry Fok, John Posner, Jane Holmes, Adrian Mander, Jonathan Corcoran   +10 more
openalex   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

A tumour suppressive relationship between mineralocorticoid and retinoic acid receptors activates a transcriptional program consistent with a reverse Warburg effect in breast cancer. [PDF]

Breast Cancer Res, 2020
Doan TB, Cheung V, Clyne CD, Hilton HN, Eriksson N, Young MJ, Funder JW, Muscat GEO, Fuller PJ, Clarke CL, Graham JD.   +10 more
europepmc   +1 more source

Significance of ETV6 rearrangement in acute promyelocytic leukemia with t(15;17)/promyelocytic leukemia/retinoic acid receptor alpha

, 2016
Na Gao, WEN-ZHENG YU, XUE-XIA WANG, JIAN-RONG SUN, Ning Yu, Zengyan Liu, XIAO-DAN LIU, R Liu, Rui Feng, Butong Ding, Tan Sang, Guo Nong-jian   +11 more
openalex   +2 more sources

Evaluating the Endocrine‐Disrupting and Oxidative Stress Potential of a 50‐Component Human‐Relevant Complex Chemical Mixture Using In Vitro Tests

Journal of Applied Toxicology, EarlyView.
ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt, Nathalie Struwe, Annika Jansson, Vesna Munic Kos, Maria Larsson, Jana M. Weiss   +5 more
wiley   +1 more source

New ligands of the Cellular Retinoic Acid-Binding Protein 2 (CRABP2) suggest a role for this protein in chromatin remodeling

Revista de Ciências Farmacêuticas Básica e Aplicada, 2014
Retinoic acid (RA) regulates the transcription of a series of genes involved in cell proliferation, differentiation and apoptosis by binding to the RA Receptor (RAR) and Retinoid X Receptor (RXR) heterodimers. The cellular retinoic acid-binding protein 2
Daniella Barros Rossetto, Eric Nishimura Kiyomoto, Carlos Eduardo Brantis de Carvalho, Cleslei Fernando Zanelli, Sandro Roberto Valentini   +4 more
doaj   +2 more sources