Results 131 to 140 of about 390,951 (380)

A combination of a T cell-derived lymphokine differentiation-inducing activity and a physiologic concentration of retinoic acid induces HL-60 to differentiate to cells with functional chemotactic peptide receptors [PDF]

, 1986
M Imaizumi, T. R. Breitman
openalex   +1 more source

The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling

Advanced Science, EarlyView.
The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu, Suhui He, Wen Shi, Jinxia Xu, Shiyang Liu, Zexu Yu, Danyue Li, Qiao Jin, Yumeng Wang, Zian Zhang, Qian Lv, Yuanxiang Ge, Yunjie Li, Xinyue Li, Nan Chen, Xinyu Fu, Yang Yang, Fushan Shi   +17 more
wiley   +1 more source

Effects of a n-3 PUFA deficient diet on the expression of retinoid nuclear receptors, neurogranin and neuromodulin in rat brain

Oléagineux, Corps gras, Lipides, 2007
A lot of studies performed in rodents revealed that n-3 polyunsaturated fatty acid (PUFA) deficient diets could induce deficits of learning capacities but the mechanisms involved are not well known.
Buaud Benjamin, Boue Carole, Combe Nicole, Higueret Paul, Pallet Véronique   +4 more
doaj   +1 more source

All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity

Cell & Bioscience, 2018
Background Bone regenerative heterodimeric bone morphogenetic protein 2/7 (BMP2/7) enhances but all-trans retinoic acid (ATRA) inhibits osteoclastogenesis.
Wenjuan Bi, Yi Liu, Jing Guo, Zhen Lin, Jinsong Liu, Miao Zhou, Daniel Wismeijer, Janak L. Pathak, Gang Wu   +8 more
doaj   +1 more source

Mycosis Fungoides, Sézary Syndrome, and Cutaneous B‐Cell Lymphomas: 2025 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov, Trilokraj Tejasvi, Ryan A. Wilcox   +2 more
wiley   +1 more source

Alitretinoin in treatment of chronic hand eczema – mechanism of action

Przegląd Dermatologiczny, 2016
Hand eczema is a common skin disorder with significant functional and economic impacts. Conventional therapy options, such as topical corticosteroids, calcineurin inhibitors, phototherapy and systemic immunosuppressants, often give unsatisfactory results,
Maria Matejko, Beata Kręcisz
doaj   +1 more source

Diglycerides of Natural Phenols and Organic Acids for Enhanced Biological Activities

Asian Journal of Organic Chemistry, EarlyView.
Diglycerides of natural organic acids and phenols were synthesized regio‐selectively. Diglycerides are structurally similar to cell membranes and are expected to exhibit cell affinity and permeability. The flexible glycerol linkers allow the diglycerides to exhibit not only the physiological activities of each constituent organic acid but also the ...
Jisu Hong, Seunghyo Han, Huisu Yeo, Chanyoung Boo, Hyein Kim, Eunbi Kim, Boram Lim, Yeon Jeong Jo, Ji‐Seon Hyun, Nam Ho Lee, Sangho Koo   +10 more
wiley   +1 more source

Multiple members of the retinoic acid receptor family are capable of mediating the granulocytic differentiation of HL-60 cells. [PDF]

, 1992
Kent A. Robertson, B Emami, LeMoyne Mueller, Steven Collins   +3 more
openalex   +1 more source

Differential Retinoic Acid Signaling in Tumors of Long- and Short-term Glioblastoma Survivors [PDF]

, 2017
Although the prognosis of most glioblastoma patients is poor, 3%-5% patients show long-term survival of 36 months or longer after diagnosis. To study the differences in activation of biochemical pathways, we performed mRNA and protein expression analyses
Barbus, Sebastian, Delhomme, Nicolas, Felsberg, Jörg, Hahn, Meinhard, Hartmann, Christian, Karra, Daniela, Krex, Dietmar, Lichter, Peter, Martinez, Ramon, Radlwimmer, Bernhard, Reifenberger, Guido, Schackert, Gabriele, Tews, Björn   +12 more
core  

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source