Results 321 to 330 of about 390,951 (380)
Some of the next articles are maybe not open access.
Retinoic acid and retinoic acid receptors in craniofacial development
Seminars in Cell & Developmental Biology, 1997Interest in retinoids and craniofacial development originated independently from nutritional and teratological studies; however, the site of action of retinoids in normal development remains contentious. Recent transgenic strategies have shown that retinoic acid and nuclear retinoid receptors are required for the morphogenetic specification of cranial ...
Paul M. Brickell, Peter Thorogood
openaire +3 more sources
The Retinoic Acid Receptors [PDF]
, 2015 Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
Hugues de Th�, Anne Dejean
openaire +1 more source
Vitamin A and Retinoic Acid in Cognition and Cognitive Disease.
Annual review of nutrition, 2020The history of vitamin A goes back over one hundred years, but our realization of its importance for the brain and cognition is much more recent. The brain is more efficient than other target tissues at converting vitamin A to retinoic acid (RA), which ...
M. Wołoszynowska-Fraser +2 more
semanticscholar +1 more source
Nuclear retinoic acid receptors: Conductors of the retinoic acid symphony during development
Molecular and Cellular Endocrinology, 2012The vitamin A derivative, retinoic acid (RA), is essential for embryonic development through the activation of cognate nuclear receptors, RARs, which work as ligand dependent regulators of transcription. In vitro studies revealed how RARs control gene expression at the molecular level and now it appears that it is fine-tuned by a phosphorylation code ...
É. Samarut, C. Rochette-Egly
semanticscholar +5 more sources
Retinoic Acid Receptors in Hematopoiesis
1996Retinoic acid receptors (RARs) are critical transcriptional regulators that are involved in the development and differentiation of a wide variety of different cells (Evans 1988). Several lines of evidence suggest that RARs may be involved in the regulation of hematopoiesis.
Irwin D. Bernstein +2 more
openaire +3 more sources
Developmental roles of the retinoic acid receptors
The Journal of Steroid Biochemistry and Molecular Biology, 1995Retinoic acid, one of the principle active metabolites of vitamin A (retinol), is believed to be essential for numerous developmental and physiological processes. Vitamin A deprivation (VAD) during development leads to numerous congenital defects. Previous studies of retinoic acid receptor (RAR) deficient mice failed to reveal any of these VAD-induced ...
Lohnes, David +8 more
openaire +5 more sources
Chronicle of a discovery: the retinoic acid receptor
Journal of Molecular Endocrinology, 2022The landmark 1987 discovery of the retinoic acid receptor (RAR) came as a surprise, uncovering a genomic kinship between the fields of vitamin A biology and steroid receptors. This stunning breakthrough triggered a cascade of studies to deconstruct the roles played by the RAR and its natural and synthetic ligands in embryonic development, skin, growth,
Vincent Giguère, Ronald M Evans
openaire +2 more sources
2010
Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Fabien Guidez +4 more
openaire +2 more sources
Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Fabien Guidez +4 more
openaire +2 more sources
Retinoic acid and its receptors
The American Journal of Surgery, 1993Retinoic acid (RA)--the active metabolite of vitamin A--and its analogues have pleiotropic effects on growth, differentiation, proliferation, and development. RA, and its analogues, determine embryonic pattern formation and inhibit tumor growth; however, they are also teratogens.
openaire +3 more sources
Transcriptional Activities of Retinoic Acid Receptors
2005Vitamin A derivatives plays a crucial role in embryonic development, as demonstrated by the teratogenic effect of either an excess or a deficiency in vitamin A. Retinoid effects extend however beyond embryonic development, and tissue homeostasis, lipid metabolism, cellular differentiation and proliferation are in part controlled through the retinoid ...
Lefebvre, P. +5 more
openaire +4 more sources