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Retinoic Acid Nuclear Receptors [PDF]
, 1991 The pleiotropic effects that RA exerts during vertebrate development have been studied in a number of experimental systems. For example, retinoic acid (RA) is thought to be the morphogen released by the zone of polarizing activity (ZPA) in the developing chick limb bud (see Smith et al., 1989) for review, and also several other articles in the present ...
N. Brand +7 more
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Identification of a receptor for the morphogen retinoic acid
Nature, 1987Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors. Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.
Ronald M. Evans +3 more
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1995
Retinoids, a class of hydrophobic compounds including retinol (vitamin A), retinoic acid (RA) and a series of natural and synthetic derivatives, exhibit a vast array of profound and diverse effects on vertebrate development from early embryogenesis to maturity.
Marie Keaveney, Hendrik G. Stunnenberg
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Retinoids, a class of hydrophobic compounds including retinol (vitamin A), retinoic acid (RA) and a series of natural and synthetic derivatives, exhibit a vast array of profound and diverse effects on vertebrate development from early embryogenesis to maturity.
Marie Keaveney, Hendrik G. Stunnenberg
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Altered retinoic acid receptors
The FASEB Journal, 1996Structurally and functionally altered retinoic acid receptors have been associated with rare human neoplasms: acute promyelocytic leukemia and hepatocellular carcinoma. Whereas the retinoic acid receptor beta (RARbeta) rearrangement in hepatocellular carcinoma is unique, in acute promyelocytic leukemia (APL), RARalpha fusion to the promyelocytic ...
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Retinoic Acid Receptor Alpha Amplifications and Retinoic Acid Sensitivity in Breast Cancers
Clinical Breast Cancer, 2013Molecular segmentation of breast cancer allows identification of small groups of patients who present high sensitivity to targeted agents. A patient, with chemo- and trastuzumab-resistant HER2-overexpressing breast cancer, who presented concomitant acute promyelocytic leukemia, showed a response in her breast lesions to retinoic acid, arsenic, and ...
S. Alsafadi +13 more
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Development, 1990
We report here the gene expression patterns, as revealed by in situ hybridisation, of the retinoic acid receptors alpha, beta and gamma (RAR-alpha, -beta and -gamma), and the cellular binding proteins for retinol and retinoic acid (CRBP, CRABP) in non ...
P. Dollé +4 more
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We report here the gene expression patterns, as revealed by in situ hybridisation, of the retinoic acid receptors alpha, beta and gamma (RAR-alpha, -beta and -gamma), and the cellular binding proteins for retinol and retinoic acid (CRBP, CRABP) in non ...
P. Dollé +4 more
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Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene
Nature, 1990Retinoic acid, the first morphogen described so far in vertebrates, is a vitamin A derivative which exerts striking effects on development and differentiation. The identification of three retinoic acid receptors as members of the nuclear receptor super-family provides an explantation for the molecular action of morphogens on gene expression. Functional
de Thé, Hugues +4 more
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Biochemical and Biophysical Research Communications, 1990
Retinoids of a structurally new type, 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylcarbamoyl)benzoic acid (Am80) and (E)-4-[3-(3,5-di-tert-butylphenyl)-3-oxo-1-propenyl]-benzoic acid (Ch55), were used for the investigation of retinoid receptors in some human cell lines.
Hiroyuki Kagechika +2 more
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Retinoids of a structurally new type, 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylcarbamoyl)benzoic acid (Am80) and (E)-4-[3-(3,5-di-tert-butylphenyl)-3-oxo-1-propenyl]-benzoic acid (Ch55), were used for the investigation of retinoid receptors in some human cell lines.
Hiroyuki Kagechika +2 more
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Receptors | Retinoic Acid Receptors
Encyclopedia of Biological Chemistry III, 2021M. Petkovich, Vivian Kitainda
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Mechanisms of transactivation by retinoic acid receptors
BioEssays, 1993AbstractRetinoids play an important role in development and differentiation(1,2). Their effect is mediated through nuclear receptors, RAR (α, β and γ) and RXR (α, β and γ),Abbreviations. RAR: retinoic acid receptor; RXR: retinoid X receptor; T3:thyroid hormone receptor; VD3R: vitamin D3 receptor; PPAR: peroxisome proliferator activated receptor; EcR ...
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