Results 41 to 50 of about 121,956 (356)

Trifarotene: A Current Review and Perspectives in Dermatology

Biomedicines, 2021
Retinoids have numerous applications in inflammatory, dyskeratotic, and oncohematology diseases. Retinoids have now reached the fourth generation, progressively reducing toxicity whilst increasing their efficacy.
Terenzio Cosio, Monia Di Prete, Roberta Gaziano, Caterina Lanna, Augusto Orlandi, Paolo Di Francesco, Luca Bianchi, Elena Campione   +7 more
doaj   +1 more source

Abnormal retinoid and TrkB signaling in the prefrontal cortex in mood disorders.

Cerebral Cortex, 2015
The prefrontal cortex shows structural and functional alterations in mood disorders. Retinoid signaling, brain-derived neurotrophic factor (BDNF), and its receptor TrkB are reported to be involved in depression.
Xin-Rui Qi, Jun Zhao, Ji Liu, Hui Fang, D. Swaab, Jiang-Ning Zhou   +5 more
semanticscholar   +1 more source

Effect of Am-80, A Novel Retinoid Derivative, On Contact Hypersensitivity Caused by Repeated Applications of Hapten in Mice

Allergology International, 2000
Some retinoids show an anti-inflammatory action through regulation of transcription of various genes. In the present study, the inhibitory effect of 4-((5,6,7,8- tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) carbamoyl) benzoic acid (Am-80), a synthetic ...
Satoru Niwa, Yousuke Hirano, Ting Wang, Takashi Ochi, Naoki Inagaki, Koichi Shudo, Hiroichi Nagai   +6 more
doaj   +1 more source

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

Genes & Development, 1995
We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA) activates transcription in the presence of LXR alpha, a member of the nuclear receptor superfamily.
P. J. Willy, K. Umesono, E. Ong, R. Evans, R. Heyman, D. Mangelsdorf   +5 more
semanticscholar   +1 more source

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

Nucleic Acids Research, 2012
Cellular oxidative and electrophilic stress triggers a protective response in mammals regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes.
B. Chorley, Michelle R. Campbell, Xuting Wang, M. Karaca, Deepa Sambandan, Fatu Bangura, P. Xue, J. Pi, S. Kleeberger, D. Bell   +9 more
semanticscholar   +1 more source

Disturbed retinoid metabolism upon loss of rlbp1a impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina

eLife, 2021
The RLBP1 gene encodes the 36 kDa cellular retinaldehyde-binding protein, CRALBP, a soluble retinoid carrier, in the visual cycle of the eyes. Mutations in RLBP1 are associated with recessively inherited clinical phenotypes, including Bothnia dystrophy ...
Domino K Schlegel, Srinivasagan Ramkumar, Johannes von Lintig, Stephan CF Neuhauss   +3 more
doaj   +1 more source

Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.

Journal of Biological Chemistry, 2000
Tangier disease, a condition characterized by low levels of high density lipoprotein and cholesterol accumulation in macrophages, is caused by mutations in the ATP-binding cassette transporter ABC1.
P. Costet, Yi Luo, Nan Wang, A. Tall
semanticscholar   +1 more source

Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate. [PDF]

, 2017
The light absorbing chromophore in opsin visual pigments is the protonated Schiff base of 11-cis-retinaldehyde (11cRAL). Absorption of a photon isomerizes 11cRAL to all-trans-retinaldehyde (atRAL), briefly activating the pigment before it dissociates ...
Fain, Gordon L, Hakobyan, Hayk, Ingram, Norianne T, Kaylor, Joanna J, Travis, Gabriel H, Tsan, Avian, Xu, Tongzhou   +6 more
core   +1 more source

Genetic Variations of Vitamin A-Absorption and Storage-Related Genes, and Their Potential Contribution to Vitamin A Deficiency Risks Among Different Ethnic Groups

Frontiers in Nutrition, 2022
Vitamin A, an essential fat-soluble micronutrient, plays a critical role in the body, by regulating vision, immune responses, and normal development, for instance.
Masako Suzuki, Meika Tomita
doaj   +1 more source

Chemistry of the Retinoid (Visual) Cycle

Chemical Reviews, 2013
As succinctly summarized by Wolf,1 lack of vitamin A (all-trans-retinol) was recognized by ancient Egyptians as causing a visual deficiency involving the retina and cornea that could be cured by eating liver.
P. Kiser, M. Golczak, K. Palczewski
semanticscholar   +1 more source