Results 21 to 30 of about 50,541 (213)
eLife, 2021 The RLBP1 gene encodes the 36 kDa cellular retinaldehyde-binding protein, CRALBP, a soluble retinoid carrier, in the visual cycle of the eyes. Mutations in RLBP1 are associated with recessively inherited clinical phenotypes, including Bothnia dystrophy ...
Domino K Schlegel +3 more
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Epigenetic Silencing of Cellular Retinol-Binding Proteins in Nasopharyngeal Carcinoma
Neoplasia: An International Journal for Oncology Research, 2005 Aberrant retinoid signaling in human cancers is extending from the nucleus to the cytoplasm. Recently, we have demonstrated frequent epigenetic inactivation of a retinoic acid receptor (RAR), RARβ2, in nasopharyngeal carcinoma (NPC).
Joseph Kwong +7 more
doaj +1 more source
Systemic retinoids and scar dehiscence
Indian Journal of Dermatology, 2019 Systemic retinoids such as isotretinoin and acitretin are associated with numerous side effects but are therapeutically valuable in dermatological practice.
Hasan Mete Aksoy, Berna Aksoy
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Nanomaterials, 2020 Retinyl palmitate is a vitamin A ester belonging to the family of endogenous natural retinoid and used to treat various skin disorders like acne, skin aging, wrinkles, and dark spots, as well as to protect against psoriasis. Despite the known therapeutic
Mohammed S. Algahtani +2 more
doaj +1 more source
Angewandte Chemie, EarlyView.Modifying the conformational ensemble of “molten‐globule” protein by the site‐specific incorporation of stereoisomeric 4‐fluoroproline residues modulated its binding affinity and aggregation behavior. 19F NMR spectroscopy enabled the detection of key interactions responsible for structural and dynamic changes. ABSTRACT Recently, the application of deep
Abir Ben Bouzayene +5 more
wiley +2 more sources
Allergology International, 2000 Some retinoids show an anti-inflammatory action through regulation of transcription of various genes. In the present study, the inhibitory effect of 4-((5,6,7,8- tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) carbamoyl) benzoic acid (Am-80), a synthetic ...
Satoru Niwa +6 more
doaj +1 more source
Biomolecules, 2019 During development, growth cones are essential for axon pathfinding by sensing numerous guidance cues in their environment. Retinoic acid, the metabolite of vitamin A, is important for neurite outgrowth during vertebrate development, but may also play a ...
Alysha Johnson +2 more
doaj +1 more source
Potential Effects of Oral Isotretinoin on Growth Plate and Height
Endocrines, 2023 Longitudinal growth and puberty are the result of a complex interaction of genetic, hormonal, nutritional, and environmental factors. Acne vulgaris is a chronic disease of the pilosebaceous unit that affects 85% of adolescents worldwide.
Adriane A. Cardoso-Demartini +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Trifarotene: A Current Review and Perspectives in Dermatology
Biomedicines, 2021 Retinoids have numerous applications in inflammatory, dyskeratotic, and oncohematology diseases. Retinoids have now reached the fourth generation, progressively reducing toxicity whilst increasing their efficacy.
Terenzio Cosio +7 more
doaj +1 more source