Results 1 to 10 of about 50,541 (213)

Topical Retinoids in Acne Vulgaris and Acne Scars—From Monotherapy to Combining Regimens [PDF]

Pharmaceuticals
Topical retinoids are the cornerstone of the treatment of multiple dermatological conditions. Long established in acne therapy, they exert effects on keratinization, inflammation, fibroblast activity, and collagen remodeling, suggesting a potential role ...
Aleksandra Tobiasz, Alina Jankowska-Konsur, Danuta Nowicka   +2 more
doaj   +2 more sources

Retinoid Signaling in Pancreatic Cancer, Injury and Regeneration

PLoS ONE, 2011
BackgroundActivation of embryonic signaling pathways quiescent in the adult pancreas is a feature of pancreatic cancer (PC). These discoveries have led to the development of novel inhibitors of pathways such as Notch and Hedgehog signaling that are ...
Mark Pinese, Andrew Biankin, Christopher Scarlett   +2 more
exaly   +3 more sources

Signalling through RXRβ and its agonist, bexarotene, promotes neuron formation in Xenopus laevis embryos [PDF]

Biology Open
Daniela Lopes Cardoso, Marilena Loizou, Danai D. Fourla, Charles Woodman, Matthew J. Guille, Colin Sharpe   +5 more
doaj   +2 more sources

Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans

Frontiers in Molecular Biosciences, 2022
Carotenoid metabolism is critical for diverse physiological processes. The nematode Caenorhabditis elegans has two genes that are annotated as β-carotene 15,15′-monooxygenase (BCMO) and are 17 centimorgan apart on chromosome II, but the function of BCMO ...
Weimin Pan, Yong-Ling Zhou, Jian Wang, Huai-En Dai, Xiao Wang, Xiao Wang, Lin Liu, Lin Liu   +7 more
doaj   +1 more source

Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro

Frontiers in Immunology, 2022
Altering T cell trafficking to mucosal regions can enhance immune responses towards pathogenic infections and cancers at these sites, leading to better outcomes.
Kavita R. Manhas, Pamela A. Marshall, Carl E. Wagner, Peter W. Jurutka, Michelle V. Mancenido, Hannah Z. Debray, Joseph N. Blattman   +6 more
doaj   +1 more source

Possible Therapeutics for Pseudomyxoma Peritonei: A Rare, Lethal, and the Least Investigated Disease

Journal of Coloproctology, 2023
Pseudomyxoma peritonei (PMP) refers to a growth disorder characterized by glycoprotein neoplasm in the peritoneum, where mucin oversecretion occurs.
Aarifa Nazmeen
doaj   +1 more source

Interphotoreceptor Retinoid-Binding Protein (IRBP) in Retinal Health and Disease

Frontiers in Cellular Neuroscience, 2020
Interphotoreceptor retinoid-binding protein (IRBP), also known as retinol binding protein 3 (RBP3), is a lipophilic glycoprotein specifically secreted by photoreceptors.
Shaoxue Zeng, Shaoxue Zeng, Ting Zhang, Michele C. Madigan, Michele C. Madigan, Nilisha Fernando, Riemke Aggio-Bruce, Riemke Aggio-Bruce, Fanfan Zhou, Matthew Pierce, Yingying Chen, Yingying Chen, Lianlin Huang, Lianlin Huang, Riccardo Natoli, Riccardo Natoli, Mark C. Gillies, Ling Zhu   +17 more
doaj   +1 more source

Improvements in acne and skin oiliness with tazarotene 0.045% lotion in patients with oily skin

Journal of Dermatological Treatment, 2023
Background Excessive sebum production is a factor in acne development. Tazarotene 0.045% lotion has demonstrated reductions in acne lesions and acne-induced sequelae. Objective Evaluate efficacy, changes in skin oiliness, and safety with tazarotene 0.045%
Emil A. Tanghetti, Joshua A. Zeichner, Michael Gold, Neil Sadick, Fran E. Cook-Bolden, Leon H. Kircik, Linda Stein Gold, Jonathan Weiss, Stephen K. Tyring, James Q. Del Rosso, Eric Guenin   +10 more
doaj   +1 more source

The Transcriptional Role of Vitamin A and the Retinoid Axis in Brown Fat Function

Frontiers in Endocrinology, 2020
In recent years, brown adipose tissue (BAT) has gained significance as a metabolic organ dissipating energy through heat production. Promotion of a thermogenic program in fat holds great promise as potential therapeutic tool to counteract weight gain and
Carsten T. Herz, Florian W. Kiefer
doaj   +1 more source

Enhancement of Efficacy of Retinoids through Enhancing Retinoid-Induced RAR Activity and Inhibiting Hydroxylation of Retinoic Acid, and Its Clinical Efficacy on Photo-Aging

Pharmaceutics, 2022
Retinoids, one of the most robust bioactive materials, have been widely used to improve various dermatological and pathological conditions. The body has an endogenous mechanism that modulates the exogenous retinoid above physiological concentrations ...
Seongsu Kang, Hyejin Lee, Seung-Hyun Jun, Sun-Gyoo Park, Nae-Gyu Kang   +4 more
doaj   +1 more source