Results 41 to 50 of about 50,541 (213)

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Aggressive Periodontitis and Palmoplantar Keratoderma: Papillon–Lefèvre Syndrome in an 11‐Year‐Old Nepalese Girl

Clinical Case Reports
Papillon–Lefèvre syndrome is a rare autosomal recessive disorder characterized by palmoplantar keratoderma and aggressive periodontitis. We report an 11‐year‐old Nepalese girl presenting with severe periodontal destruction and characteristic cutaneous ...
Jenisha Bhattarai, Sanish Pokhrel, Yogendra Poudel, Ujjwal Rimal   +3 more
doaj   +2 more sources

Effect of Hyperoxia on Retinoid Metabolism and Retinoid Receptor Expression in the Lungs of Newborn Mice. [PDF]

PLoS ONE, 2015
Preterm newborns that receive oxygen therapy often develop bronchopulmonary dysplasia (BPD), which is abnormal lung development characterized by impaired alveologenesis.
Hsing-Jin Chen, Bor-Luen Chiang
doaj   +1 more source

Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation

Advanced Science, 2022
A recently developed synthetic retinoid abrogates proliferation and induces apoptosis of drug‐resistant malignant‐cancer‐stem‐cell‐like cells. However, the underlying mechanisms of how the synthetic retinoid induces cancer‐stem‐cell‐like cell tumor ...
Yao Zhang, Qi Dong, Quanlin An, Chumei Zhang, Erfan Mohagheghian, Bing Niu, Feng Qi, Fuxiang Wei, Sihan Chen, Xinman Chen, Anqi Wang, Xin Cao, Ning Wang, Junwei Chen   +13 more
doaj   +1 more source

Targeted disruption of the mouse cis-retinol dehydrogenase gene: visual and nonvisual functions

Journal of Lipid Research, 2002
It has been proposed that cis-retinol dehydrogenase (cRDH) acts within the body to catalyze the oxidation of 9-cis-retinol, an oxidative step needed for 9-cis-retinoic acid synthesis, the oxidation of 11-cis-retinol [an oxidative step needed for 11-cis ...
Enyuan Shang, Katherine Lai, Alan I. Packer, Jisun Paik, William S. Blaner, Milena de Morais Vieira, Peter Gouras, Debra J. Wolgemuth   +7 more
doaj   +1 more source

Unraveling the Plasma Extracellular Vesicles Proteome: Predictors of Resistance in Immunotherapy of Advanced Melanoma

International Journal of Cancer, EarlyView.
ABSTRACT Despite substantial clinical benefit from immune checkpoint inhibitors (ICI), advanced melanoma remains challenging due to frequent treatment resistance. Resistance may be intrinsic (primary) or emerge over time (secondary). Biomarkers predicting distinct resistance phenotypes before therapy are lacking.
Julian Kött, Glenn Geidel, Carmen M. T. Roeper, Lucija Ačkar, Bente Siebels, Hannah Voß, Hartmut Schlüter, Michaela Schweizer, Kilian Müller, Alessandra Rünger, Tim Zell, Benjamin Deitert, Ali Zeinal‐Abedini, Isabel Heidrich, Stefan W. Schneider, Klaus Pantel, Daniel J. Smit, Christoffer Gebhardt   +17 more
wiley   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik, Asuman Deveci Ozkan, Tuğba Kotil, Nazan Deniz Yön   +3 more
wiley   +1 more source

Differentiation of human epidermal keratinocytes is accompanied by increased expression of CRABP-II and increased cellular concentration of retinoic acids: retention of newly synthesized retinoic acids by CRABP-II

Journal of Lipid Research, 1998
Keratinocytes differentiating in vitro exhibit greater cytosolic capacity for retinoic acid synthesis from retinol or retinaldehyde as compared to nondifferentiated cells (Siegenthaler et al. 1990. Biochem. J.
Dominique Chatellard-Gruaz, R. Keith Randolph, Gerry Hagens, Jean-Hilaire Saurat, Georges Siegenthaler   +4 more
doaj   +1 more source

Transparent Surfactant‐Based Isotropic Systems for Topical Co‐Delivery of Hydrophilic and Lipophilic Actives for Striae Distensae

Journal of Surfactants and Detergents, EarlyView.
ABSTRACT Striae distensae are common dermal lesions that negatively affect skin appearance, and topical management remains limited by challenges related to skin deposition and residence time. Here, we developed transparent surfactant‐based isotropic systems for the topical co‐delivery of ascorbic acid (AA), retinoic acid (RA), and lavender essential ...
Claudiane Ayres Prochno, Anna Paula Brusamarello, Anna Cláudia Morais de Oliveira Capote, Thais Leticia Moreira da Silva, Gabriela Ruva Fagundes, Giovani Marino Favero, Marina Tolentino Marinho, Benjamim Melo de Carvalho, Priscileila Colerato Ferrari   +8 more
wiley   +1 more source

Self-Assembly Of Retinoid Nanoparticles For Melanoma Therapy

International Journal of Nanomedicine, 2019
Han Liao,1,2 Shan Zhao,1,2 Huihui Wang,1,2 Yang Liu,1 Ying Zhang,1 Guangwei Sun1 1Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People’s Republic of China ...
Liao H, Zhao S, Wang H, Liu Y, Zhang Y, Sun G   +5 more
doaj