Results 61 to 70 of about 121,956 (356)
Retinoid signaling in pancreatic cancer, injury and regeneration.
PLoS ONE, 2011 BackgroundActivation of embryonic signaling pathways quiescent in the adult pancreas is a feature of pancreatic cancer (PC). These discoveries have led to the development of novel inhibitors of pathways such as Notch and Hedgehog signaling that are ...
Emily K Colvin +14 more
doaj +1 more source
Advanced Science, EarlyView.This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao +17 more
wiley +1 more source
Offshore Crude Oil Disrupts Retinoid Signaling and Eye Development in Larval Atlantic Haddock
Frontiers in Marine Science, 2019 The aim of this study was to examine the impact of dispersed crude oil on retinoid metabolism and signaling in developing haddock larvae (Melanogrammus aeglefinus).
Kai K. Lie +5 more
doaj +1 more source
Advances in breast cancer treatment and prevention: preclinical studies on aromatase inhibitors and new selective estrogen receptor modulators (SERMs). [PDF]
, 2003 Intensive basic and clinical research over the past 20 years has yielded crucial molecular understanding into how estrogen and the estrogen receptor act to regulate breast cancer and has led to the development of more effective, less toxic, and safer ...
Brown, Powel H +2 more
core +2 more sources
Advanced Science, EarlyView.Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li +11 more
wiley +1 more source
YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis
Advanced Science, EarlyView.This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li +8 more
wiley +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov +2 more
wiley +1 more source
Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function [PDF]
, 2018 Visual function in vertebrates critically depends on the continuous regeneration of visual pigments in rod and cone photoreceptors. RPE65 is a well-established retinoid isomerase in the pigment epithelium that regenerates rhodopsin during the rod visual ...
Angueyra, Juan M +11 more
core +1 more source
Linking Induction and Transrepression of PPARβ/δ with Cellular Function [PDF]
, 2015 The copyrights of all papers published in this journal are retained by the respective authors as per the 'Creative Commons Attribution License' (http://creativecommons.org/licenses/by/3.0/).Peroxisome proliferator activated receptors (PPARs) are ligand ...
MacKenzie, Louise Susan +1 more
core +2 more sources
Diglycerides of Natural Phenols and Organic Acids for Enhanced Biological Activities
Asian Journal of Organic Chemistry, EarlyView.Diglycerides of natural organic acids and phenols were synthesized regio‐selectively. Diglycerides are structurally similar to cell membranes and are expected to exhibit cell affinity and permeability. The flexible glycerol linkers allow the diglycerides to exhibit not only the physiological activities of each constituent organic acid but also the ...
Jisu Hong +10 more
wiley +1 more source