Results 81 to 90 of about 121,956 (356)

Studies on the mechanism of retinoid-induced pattern duplications in the early chick limb bud: temporal and spatial aspects. [PDF]

, 1985
All-trans-retinoic acid causes striking digit pattern changes when it is continuously released from a bead implanted in the anterior margin of an early chick wing bud.
Alberts, BM, Eichele, G, Tickle, C
core  

The Role of Specific Retinoid Receptors in Sebocyte Growth and Differentiation in Culture11Presented in part at the 1999 Annual Meeting of the Pediatric Academic Societies, San Francisco, CA, May 1–4 (Pediat Res 45 (Part 2): 55A [Abst 313] 1999) [PDF]

, 2000
Retinoic acid derivatives (retinoids) exert their pleiotropic effects on cell development through specific nuclear receptors, the retinoic acid receptors and retinoid X receptors.
Ciletti, Nancy, Kim, Mi-Jung, Michel, Serge, Reichert, Uwe, Rosenfield, Robert L.   +4 more
core   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. [PDF]

, 2017
PurposeThe RPE cell line ARPE-19 provides a dependable and widely used alternative to native RPE. However, replication of the native RPE phenotype becomes more difficult because these cells lose their specialized phenotype after multiple passages ...
Duncan, Todd, Jaworski, Cynthia, Kutty, R Krishnan, Lakkaraju, Aparna, Poliakov, Eugenia, Postnikova, Olga A, Redmond, T Michael, Samuel, William, Tan, Li Xuan   +8 more
core   +2 more sources

Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis [PDF]

, 2005
Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed
Commodaro, Alessandra G., Martín, Andrea P., Rabinovich, Gabriel Adrián, Rizzo, Luiz V., Serra, Horacio Marcelo, Tadokoro, Carlos E., Urrets Zavalia, Enrique, Urrets Zavalía, Julio Alberto, Vieira de Moraes, Luciana   +8 more
core   +1 more source

A head start: The relationship of placental factors to craniofacial and brain development

Developmental Dynamics, EarlyView.
Abstract In recent years, the importance of placental function for fetal neurodevelopment has become increasingly studied. This field, known as neuroplacentology, has greatly expanded possible etiologies of neurodevelopmental disorders by exploring the influence of placental function on brain development.
Annemarie Jenna Carver, Martine Dunnwald, Hanna Elizabeth Stevens   +2 more
wiley   +1 more source

Self-Assembly Of Retinoid Nanoparticles For Melanoma Therapy

International Journal of Nanomedicine, 2019
Han Liao,1,2 Shan Zhao,1,2 Huihui Wang,1,2 Yang Liu,1 Ying Zhang,1 Guangwei Sun1 1Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People’s Republic of China ...
Liao H, Zhao S, Wang H, Liu Y, Zhang Y, Sun G   +5 more
doaj  

Efficacy and safety of fixed-dose clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel in Hispanic participants with moderate-to-severe acne: a pooled analysis

Journal of Dermatological Treatment
Introduction Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel is the only fixed-dose, triple-combination approved for acne. In phase 2 and 3 studies, CAB demonstrated superior efficacy to vehicle and component dyads.
Valerie D. Callender, Hilary Baldwin, Linda Stein Gold, Fran E. Cook-Bolden, Eric Guenin, Andrew F. Alexis   +5 more
doaj   +1 more source

Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne. [PDF]

, 2019
BACKGROUND: Acne vulgaris often affects the face, shoulders, chest, and back, but treatment of nonfacial acne has not been rigorously studied. OBJECTIVES: Assess the safety and efficacy of trifarotene 50 μg/g cream, a novel topical retinoid, in moderate ...
Ahmad, Faiz, Alió Saenz, Alessandra, Blume-Peytavi, Ulrike, Del Rosso, James, Gooderham, Melinda, Graeber, Michael, Johnson, Sandra, Lynde, Charles, Parish, Lawrence, Popp, Georg, Sanchez Colon, Nestor, Stein Gold, Linda, Tan, Jerry, Thiboutot, Diane, Weglovska, Jolanta, Weiss, Jonathan, Witkowska, Dagmara   +16 more
core   +1 more source

A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion [PDF]

, 2018
Key Points Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.
Duncavage, Eric J., Griffith, Malachi, Griffith, Obi L., Hassan, Anjum, Lee, Yi-Shan, Miller, Christopher A., O\u27Laughlin, Michelle D., Schmidt, Heather, Skidmore, Zachary L., Tian, Ling, Tricarico, Christopher, Uy, Geoffrey L., Wartman, Lukas D., Welch, John S.   +13 more
core   +2 more sources