Results 91 to 100 of about 905,398 (250)

New Treatment Strategy and Future Research Direction for BRAF‐Mutated Cancer

Cancer Science, EarlyView.
Treatment with BRAF inhibitor plus MEK inhibitor is currently used in BRAF‐mutated various malignancies except colorectal cancer, and treatments with BRAF and/or MEK inhibitors and anti‐EGFR antibody are used in BRAF‐mutated colorectal cancer. Despite recent advances in BRAF‐targeted therapies, their efficacy is still limited.
Masanobu Takahashi, Sakura Hiraide Taniguchi, Yuya Yoshida   +2 more
wiley   +1 more source

Identification of Macrophage Genotype and Key Biological Pathways in Circulating Angiogenic Cell Transcriptome

Stem Cells International, 2019
Background. Circulating angiogenic cells (CAC) have been identified as important regulators of vascular biology. However, there is still considerable debate about the genotype and function of CAC. Methods and Results.
Bert R. Everaert, Steven J. Van Laere, Robrecht Lembrechts, Vicky Y. Hoymans, Jean-Pierre Timmermans, Christiaan J. Vrints   +5 more
doaj   +1 more source

The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients

Frontiers in Aging Neuroscience, 2019
These days, the important role of retinoids in adult brain functionality and homeostasis is well accepted and has been proven by genomic as well as non-genomic mechanisms.
Malena dos Santos Guilherme, Nicolai M. Stoye, Stefan Rose-John, Christoph Garbers, Andreas Fellgiebel, Kristina Endres   +5 more
doaj   +1 more source

S1 Guideline: Therapy of generalized pustular psoriasis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The S1 guideline “Therapy of generalized pustular psoriasis (GPP)” is a German guideline developed in accordance with the criteria of the AWMF. The full version addresses clinical presentation, pathogenesis, diagnosis and differential diagnosis, comorbidities, and therapy.
Rotraut Mößner, Neda Cramer, Sascha Gerdes, Ulrike Hüffmeier, Andreas Körber, Kai Krause, Christian Kromer, Katharina Antonia Langen, Sandra Philipp, Knut Schäkel, Michael P. Schön, Michael Schultheis, Lukas Sollfrank, Petra Staubach, Michael Sticherling, Johannes Wohlrab, Dagmar Wilsmann‐Theis, Cornelia Paul   +17 more
wiley   +1 more source

Mild whole-body heat stress alters retinoid metabolism in the rat small intestine

, 2006
Mild heat treatment can modulate metabolism and prevent stress-induced alterations in cells and tissues. Retinoids are known to influence cellular metabolism and are essential for growth and differentiation, particularlepithelial tissue.
Prabhu Ramamoorthy, Thomas, Simmy, Ramachandran, Anup, Ramamoorthy, Prabhu, Kunissery A. Balasubramanian, Anup Ramachandran, Simmy Thomas, Balasubramanian, Kunissery A.   +7 more
core   +1 more source

Vitamin A Metabolism: An Update [PDF]

, 2011
Retinoids are required for maintaining many essential physiological processes in the body, including normal growth and development, normal vision, a healthy immune system, normal reproduction, and healthy skin and barrier functions.
Clugston, Robin D., Robin D. Clugston, William S. Blaner, Blaner, William S., D'Ambrosio, Diana N., Diana N. D’Ambrosio   +5 more
core   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Effects of PPARγ Ligands on Leukemia

PPAR Research, 2012
Peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RARs), members of the nuclear receptor superfamily, are transcription factors that regulate a variety of important cellular functions.
Yoko Tabe, Marina Konopleva, Michael Andreeff, Akimichi Ohsaka   +3 more
doaj   +1 more source

Retinoid metabolism: a balancing act [PDF]

Nature Genetics, 2002
The recent characterization of the alcohol* dehydrogenase Aldh1a2 and the cytochrome P450 Cyp26, two enzymes involved in retinoid metabolism, has helped to explain how bioactive retinoids are made and catabolized. By the elegant definition of an Aldh1a2 null mutation as a dominant suppressor of a Cyp26 null mutation, it is now unequivocally ...
openaire   +1 more source

PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression [PDF]

, 2008
Background The selective absorption of nutrients and other food constituents in the small intestine is mediated by a group of transport proteins and metabolic enzymes, often collectively called 'intestinal barrier proteins'.
Hooiveld, Guido J E J, Bosch, H.M., van den, de Groot, Philip, de Vogel-van den Bosch, Heleen, de Groot Philip J, de Groot, P.J., Hooiveld Guido JEJ, de Vogel-van den Bosch Heleen M, Müller, M.R., Bosch-Vermeulen, Hanneke, Heleen M de Vogel-van den Bosch, Hooiveld, Guido, Bosch - Vermeulen, Hanneke, Philip J de Groot, Bünger, Meike, Bosch-Vermeulen Hanneke, Bünger Meike, de Vogel-van den Bosch, Heleen M, Müller Michael, Müller, Michael, Meike Bünger, Michael Müller, Hanneke Bosch-Vermeulen, Bosch-Vermeulen, H., van den Bosch, H.M., Bünger, M., Groot, P.J., de, Guido JEJ Hooiveld, Heleen M de Vogel-van den Bosch, Hooiveld, G.J.E.J., de Groot, Philip J   +30 more
core   +1 more source