Results 101 to 110 of about 905,398 (250)

Supplementary Figure 7 from Retinol Saturase Mediates Retinoid Metabolism to Impair a Ferroptosis Defense System in Cancer Cells

, 2023
RETSAT-RAR-SCD signaling pathway regulates ferroptosis via MUFA generation, and targeting retinoid metabolism might be a promising strategy in future cancer treatment.
Tao Lu (16546009), Qun Wang (16546024), Ming Li (16546012), Mengnan Zhao (16546018), Jiaqi Liang (16545994), Yunyi Bian (16546000), Guangyao Shan (16545997), Cheng Zhan (10361500), Hong Fan (16546021), Guoshu Bi (16545991), Boyi Gan (16546027), Valeria Besskaya (16546015), Zhencong Chen (16546003), Yiwei Huang (16546006)   +13 more
core   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus

Cell Reports
Summary: The hypothalamus contains multiple regions, including the ventromedial hypothalamus (VMH) and arcuate (ARC), which are responsible for sex-differentiated functions such as endocrine signaling, metabolism, and reproductive behaviors.
Bernard Mulvey, Yi Wang, Heena R. Divecha, Svitlana V. Bach, Kelsey D. Montgomery, Sophia Cinquemani, Atharv Chandra, Yufeng Du, Ryan A. Miller, Joel E. Kleinman, Stephanie C. Page, Thomas M. Hyde, Keri Martinowich, Stephanie C. Hicks, Kasper D. Hansen, Kristen R. Maynard   +15 more
doaj   +1 more source

Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene [PDF]

, 2010
Beta-carotene 15,15'-monooxygenase 1 knockout (Bcmo1 (-/-)) mice accumulate beta-carotene (BC) similarly to humans, whereas wild-type (Bcmo1 (+/+)) mice efficiently cleave BC.
Yvonne G. J. van Helden, Georg Lietz, Roger W. L. Godschalk, Jaap Keijer, Teerds, K., Hessel, S., Keijer, J., Schooten, F.J., van, Adrian Wyss, von Lintig, J., Sandra G. Heil, Heil, S.G., Kramer, E., Lietz, G., van Schooten, F.J., Lintig, J., von, Amengual, J., Wyss, A., Ribot, J., Katja Teerds, Frederik J. van Schooten, Helden, Y.G.J., Johannes von Lintig, Godschalk, R.W.L., M. Luisa Bonet, van Helden, Y.G., Evelien Kramer, Joan Ribot, Susanne Hessel, Teerds, K.J., Bonet, M.L., Jaume Amengual   +31 more
core   +1 more source

Histological manifestations of vitamin A toxicity in the liver

Histopathology, EarlyView.
Analysing clinicopathological data from 1960 to 2025, this study characterizes the spectrum of liver injury associated with chronic vitamin A toxicity. Hepatic stellate cell hypertrophy/hyperplasia and sinusoidal fibrosis emerge as the predominant features, providing a morphological basis for diagnosing vitamin A hepatotoxicity.
Giorgio Cazzaniga, Georg Lietz, Dina G. Tiniakos   +2 more
wiley   +1 more source

Retinoid Metabolism in the Degeneration of Pten-Deficient Mouse Retinal Pigment Epithelium. [PDF]

Mol Cells, 2021
Kim YJ, Park S, Ha T, Kim S, Lim S, You H, Kim JW.   +6 more
europepmc   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Lung Retinoid Metabolism and Signaling in Chronic Obstructive Pulmonary Disease

, 2014
499-505There are a number of sites that are required for the production and/or action of all-trans retinoic acid (ATRA). In particular, interruption of different components of the chain of trafficking and metabolism has been associated with cancers ...
Ong, David E, Roy, Somdutta Sinha, Mukherjee, Shyamali, Das, Salil K   +3 more
core  

Lignan‐rich Norway spruce (Picea abies) resin extract exhibits anti‐inflammatory, skin‐regenerative and anti‐acne effects: In vitro, in silico, biocompatibility and exploratory clinical findings

International Journal of Cosmetic Science, EarlyView.
GA text A 30% Picea abies resin extract cream combined antimicrobial, anti‐inflammatory and early pro‐repair activities relevant to acne‐prone skin. The formulation showed strong activity against Cutibacterium acnes, reduced inflammatory cytokines and demonstrated promising tolerability and efficacy in an exploratory in‐use study. Abstract Objective To
Simone Parrotta, Kamilla Yamileva, Laura Punakallio, Maryam Ghanbarirad, Evgen Multia   +4 more
wiley   +1 more source

Therapeutic Uses of Retinol and Retinoid-Related Antioxidants

Molecules
Retinol and retinol-related compounds are essential for human health, particularly in cellular protection, skin health, and the management of medical conditions.
Janka Vašková, Marek Stupák, Martina Vidová Ugurbaş, Jozef Židzik, Helena Mičková   +4 more
doaj   +1 more source