Results 131 to 140 of about 905,398 (250)

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

The Next Generation of Skin Care: Transforming Retinoid Therapeutics

Cells
Retinoids are central regulators of skin biology, influencing keratinocyte proliferation, differentiation, immune modulation, and barrier maintenance.
Julia Weronika Łuczak, Małgorzata Palusińska, Karolina Maślińska-Gromadka, Damian Pietrzak, Tomasz Szopiński, Sławomir Lewicki, Tino Schenk, Łukasz Szymański   +7 more
doaj   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Transplantation of Elderly Human Gut Microbiota Into Pigs Reprograms Intestinal Barrier Function, Plasma Metabolome, and Gut Mucosal Transcriptomic Landscape

Aging Cell, Volume 25, Issue 10, October 2026.
Elderly human donor microbiota disrupts intestinal barrier integrity and reshapes host metabolic and mucosal transcriptional profiles in human microbiota‐associated pigs. Integrated multi‐omics analyses identify coordinated microbial, metabolic, and host alterations associated with age‐related intestinal decline.
Jiaxin Wang, Lingyu Li, Lihua Mei, Zhining Tang, Baorui Liao, Qianye Zhao, Yuzeng Wang, Qingyao Fu, Liu Ren, Zhian Zhai, Yifei Xu, Aoyu Yang, Shuai Duan, Zhengyuan Zhai, Yanling Hao, Yalin Zhou, Yajun Xu, Ying Yang, Zhenlong Wu, Yun Ji   +19 more
wiley   +1 more source

Identification of novel pharmacological targets linked to retinoid metabolism for the treatment of advanced prostate cancer

, 2021
Prostate cancer represents the second most frequently diagnosed malignancy among men and the fifth leading cause of cancer-associated death worldwide.
Gianfanti Federico
core  

An Acidic Tubulointerstitial Microenvironment Delays Cell‐Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz, Virginie Dubourg, Lea Schaude, Natalie Schröder, Eva Janßen, Isabelle Görlich, Stefanie Ruhs, Michael Kopf, Michael Gekle   +8 more
wiley   +1 more source

Altered retinoid signaling compromises decidualization in human endometriotic stromal cells

, 2017
Decidualization alters multiple molecular pathways in endometrium to permit successful embryo implantation. We have reported that paracrine factors, including retinoids, secreted from progesterone-treated endometrial stromal cells, act on nearby ...
Mary Ellen Pavone, Serdar E Bulun, Saurabh Malpani, Matthew Dyson   +3 more
core   +1 more source

Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity

Obesity Reviews, Volume 27, Issue 10, October 2026.
ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye, Ursula Hiden, Evelyn Jantscher‐Krenn, Herbert Fluhr, Jonathan C. Wells, Sonja Entringer, Mireille N. M. van Poppel   +6 more
wiley   +1 more source

Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells. [PDF]

Elife, 2020
Lu Z, Xie Y, Huang H, Jiang K, Zhou B, Wang F, Chen T.   +6 more
europepmc   +1 more source

Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio)

, 2012
This study examined the disruptive effect of exposure to polybrominated diphenyl ethers (PBDEs) on retinoid content in zebrafish (Danio rerio). Adult zebrafish were exposed to an environmentally relevant concentration (0.45 mu g/L) and a higher ...
Huang, Changjiang, Zhou, Bingsheng, Yang, Lihua, Wang, Xiaofang, Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China., Chen, Lianguo, Wang, Qiangwei, Hu, Chenyan   +7 more
core   +1 more source