Results 151 to 160 of about 905,398 (250)

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Piezo1 in digestive homeostasis and disease: Barrier function, immune signalling, cellular injury and metabolism

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Piezo1 functions as a context‐dependent mechanotransduction node linking mechanical cues to inflammation, tissue remodelling and metabolic regulation in digestive homeostasis and disease. In epithelial, immune, stromal and endocrine cells, Piezo1‐mediated Ca2+ signalling contributes to barrier and mucus homeostasis, epithelial renewal and repair ...
Yuan Xia, Chang Liang, Zhuoqing Zhuang, Pingrun Chen, Zhe Xiong, Junzhu Lu, Yan Zhang   +6 more
wiley   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Phasor‐Based Spatio‐Spectral Segmentation for Hyperspectral Fluorescence Microscopy

Journal of Biophotonics, Volume 19, Issue 9, September 2026.
Spatially‐corrected density peak clustering (SC‐DPC) enables high‐accuracy segmentation of hyperspectral fluorescence microscopy data in the presence of significant spectral and spatial overlap between fluorophores. Validated on retinal imaging, SC‐DPC effectively separates overlapping fluorophore spectra in photon‐starved conditions, offering superior
Maciej Barna, Grazyna Palczewska, Grzegorz Soboń, Krzysztof Palczewski, Jakub Bogusławski   +4 more
wiley   +1 more source

Wnt regulates cellular differentiation and retinoid metabolism genes in the mouse stomach. [PDF]

Am J Physiol Gastrointest Liver Physiol
Delgado E, Hibdon ES, Keeley TM, Huynh CQ, Colacino JA, Samuelson LC.   +5 more
europepmc   +1 more source

Retinoid metabolism and all-trans retinoic acid-induced growth inhibition in head and neck squamous cell carcinoma cell lines

, 1997
Retinoids can reverse potentially premalignant lesions and prevent second primary tumours in patients with head and neck squamous cell carcinoma (HNSCC).
Leede, B.M. van der, Snow, G.B., Braakhuis, B.J.M., Teerlink, T., Hendriks, H.F.J., Klaassen, I., Saag, P.T. van der, Cloos, J., Brakenhoff, R.H., Copper, M.P.   +9 more
core  

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source

FOXC1 Regulates Cytokine Signaling, Inflammatory Pathways, and Retinoid Metabolism to Maintain Limbal Epithelial Cell Homeostasis In Vitro. [PDF]

Int J Mol Sci
Kundu S, Amini M, Stachon T, Fries FN, Seitz B, Li Z, Li S, Liu S, Hsu SL, Suiwal S, Szentmáry N.   +10 more
europepmc   +1 more source

The Secretome Derived From Human Umbilical Cord Mesenchymal Stem Cells Improves Skin Photoaging by Enhancing Mitophagy to Inhibit the cGAS‐STING Pathway

Aging Cell, Volume 25, Issue 9, September 2026.
HUC‐MSC‐derived SCT alleviates UV‐induced skin photoaging. It acts by enhancing mitophagy to clear damaged mitochondria, thereby suppressing the pro‐inflammatory cGAS‐STING pathway. This work identifies SCT as a novel cell‐free therapy targeting mitochondrial quality control to counteract sterile inflammation in aging. ABSTRACT Ultraviolet (UV)‐induced
Tingting Tang, Meifen Lin, Jingjing Yang, Xinyu Yang, Xunhong Xu, Xuan Wang, Yarui Zhang, Qimei Chen, Shan Zhao, Chenhui Guo, Hao Zhang, Min Zhang, Lin Zhang, Xueer Wang   +13 more
wiley   +1 more source