Results 161 to 170 of about 905,398 (250)

Endothelium-specific sensing of mechanical signals drives epidermal aging through coordinating retinoid metabolism. [PDF]

Theranostics
Wu X, Zhong J, Jiang J, Zou Y, Wang D, Chen Z, Wang M, Shen X, Li Z, Xiao Y, Yi Y, Tang F, Long X, Qiu W, Tang Q, Xiang X, Zhou X, Lei M, Shu P, Zhou Q.   +19 more
europepmc   +1 more source

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 6, Page 729-747, September 2026.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

Spatial transcriptomics identifies differentiation, lipid metabolism, and retinoid pathway alterations in acne vulgaris

JCI Insight
Acne vulgaris is a common skin condition involving complex interactions among lipid-secreting sebaceous glands, keratinocytes, immune cells, and microbiota.
Joseph S. Durgin, Natalia A. Veniaminova, Thomas J. Huyge, Shih-Ying Tsai, Jennifer Fox, Yuli Cai, Mrinal K. Sarkar, Lam C. Tsoi, Johann E. Gudjonsson, Sunny Y. Wong   +9 more
doaj   +1 more source

Cellular and molecular effects of Baccharis dracunculifolia D.C. and Plectranthus barbatus Andrews medicinal plant extracts on retinoid metabolism in the human hepatic stellate cell LX-2. [PDF]

BMC Complement Altern Med, 2019
da Silva CM, Caetano FH, Pereira FDC, Morales MAM, Sakane KK, Moraes KCM.   +5 more
europepmc   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5476-5495, September 2026.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source

Efficacy and Safety of Yellow Light Monotherapy Versus Yellow Light Combined With 20% Vitamin C for the Treatment of Melasma: A Single‐Center, Randomized, Double‐Blind, Placebo‐Controlled Clinical Study

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Melasma treatment remains challenging due to limited effective and safe options. This study evaluated the efficacy and safety of yellow light phototherapy alone versus combined with 20% vitamin C in treating melasma. Methods Seventy‐one patients were randomly assigned to receive twice‐weekly yellow light phototherapy combined with ...
Dan Du, Xu Liu, Yuwei Huang, Shuwei Wu, Xian Jiang   +4 more
wiley   +1 more source

Naringenin as a Multifunctional Ingredient Targeting Pathways Associated With Skin Inflammaging: Preclinical and Clinical Evidence

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Inflammaging, a sustained state of low‐level inflammatory activity with age, is a driving factor in age‐related changes in skin structure, function, and appearance. By perturbing fundamental biological pathways, inflammaging is a relevant target in skincare and anti‐aging research.
Taylor Oswald, Zixuan Shao, Nicholas Brideau   +2 more
wiley   +1 more source

Topical Epidermal Growth Factor in Acne Vulgaris and Acne‐Related Sequelae: Mechanistic Rationale, Clinical Evidence, and Formulation Challenges

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Acne vulgaris (AV) is a common chronic inflammatory skin disorder, particularly among adolescents and young adults, and its management remains limited by variable treatment response, poor adherence, and treatment‐related adverse effects.
Nasim Gholizadeh, Ghasem Rahmatpour Rokni, Maryam Sahafi, Omid Mohaghegh, Ardalan Etemadzadeh, Reyhaneh Pasandipour, Hamed Fakhrabadi, Ghazal Zoghi   +7 more
wiley   +1 more source

Effect of Dietary Vitamin A, Breed, and Kidney Function on the Onset of Urinary Vitamin A Excretion and the Vitamin A Transport Complex in Growing Dogs

Journal of Animal Physiology and Animal Nutrition, Volume 110, Issue 5, Page 813-819, September 2026.
ABSTRACT Vitamin A (retinol and retinyl esters) is present in substantial amounts in the urine of healthy adult dogs, but the mechanisms affecting its excretion are poorly understood. To assess whether the onset of urinary vitamin A excretion is dependent on dietary vitamin A intake, breed, and/or parameters of kidney function, 48 puppies from two ...
Jens Raila, Haydar Özpinar, Florian J. Schweigert   +2 more
wiley   +1 more source