Results 61 to 70 of about 905,398 (250)

Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis

Molecular Metabolism, 2020
Objective: Transformation of white into brown fat (“browning”) reduces obesity in many preclinical models and holds great promise as a therapeutic concept in metabolic disease. Vitamin A metabolites (retinoids) have been linked to thermogenic programming
Anna Fenzl, Oana Cristina Kulterer, Katrin Spirk, Goran Mitulović, Rodrig Marculescu, Martin Bilban, Sabina Baumgartner-Parzer, Alexandra Kautzky-Willer, Lukas Kenner, Jorge Plutzky, Loredana Quadro, Florian W. Kiefer   +11 more
doaj   +1 more source

Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection

Frontiers in Immunology, 2022
Densoviruses (DVs) are single-stranded DNA viruses and exclusively happen in invertebrates. Most of DVs reported in insects are pathogenic to their native hosts, however, no pathogenic effect of them has been examined in vertebrates.
Tong Li, Haichao Li, Haichao Li, Yuqing Wu, Shaojian Li, Guohui Yuan, Pengjun Xu   +6 more
doaj   +1 more source

Surgical stress-induced alterations in retinoid metabolism in the small intestine: role of oxygen free radicals

, 2005
Oxidative stress in the small intestine can result in altered cell proliferation, migration, and differentiation of villus-crypt cells. Retinoid metabolism is recognized as an important mediator of cellular differentiation in the intestine.
Thomas, Simmy, Balasubramanian, K. A., Prabhu, R.   +2 more
core   +1 more source

Compartmental analysis of the dynamics of beta-carotene metabolism in an adult volunteer.

Journal of Lipid Research, 1995
Metabolism of a 73 mumol oral dose of beta-carotene-d8 in olive oil was determined from plasma beta-carotene-d8 and retinol-d4 concentration-time curves in an adult male. beta-Carotene-d8 and retinol-d4 concentrations in serial plasma were measured using
J.A. Novotny, S.R. Dueker, L.A. Zech, A.J Clifford   +3 more
doaj   +1 more source

Molecular Mechanisms of Retinoid Receptors in Diabetes-Induced Cardiac Remodeling

, 2014
Diabetic cardiomyopathy (DCM), a significant contributor to morbidity and mortality in diabetic patients, is characterized by ventricular dysfunction, in the absence of coronary atherosclerosis and hypertension.
Jing Pan, Rakeshwar Guleria, Sen Zhu, Kenneth Baker   +3 more
core   +1 more source

Supplementary Figure 4 from Retinol Saturase Mediates Retinoid Metabolism to Impair a Ferroptosis Defense System in Cancer Cells

, 2023
RETSAT links retinoid metabolism to ferroptosis.
Tao Lu (16546009), Qun Wang (16546024), Ming Li (16546012), Mengnan Zhao (16546018), Jiaqi Liang (16545994), Yunyi Bian (16546000), Guangyao Shan (16545997), Cheng Zhan (10361500), Hong Fan (16546021), Guoshu Bi (16545991), Boyi Gan (16546027), Valeria Besskaya (16546015), Zhencong Chen (16546003), Yiwei Huang (16546006)   +13 more
core   +1 more source

Unraveling the Plasma Extracellular Vesicles Proteome: Predictors of Resistance in Immunotherapy of Advanced Melanoma

International Journal of Cancer, EarlyView.
ABSTRACT Despite substantial clinical benefit from immune checkpoint inhibitors (ICI), advanced melanoma remains challenging due to frequent treatment resistance. Resistance may be intrinsic (primary) or emerge over time (secondary). Biomarkers predicting distinct resistance phenotypes before therapy are lacking.
Julian Kött, Glenn Geidel, Carmen M. T. Roeper, Lucija Ačkar, Bente Siebels, Hannah Voß, Hartmut Schlüter, Michaela Schweizer, Kilian Müller, Alessandra Rünger, Tim Zell, Benjamin Deitert, Ali Zeinal‐Abedini, Isabel Heidrich, Stefan W. Schneider, Klaus Pantel, Daniel J. Smit, Christoffer Gebhardt   +17 more
wiley   +1 more source

Overview of the retinoid metabolism in vertebrates

, 2012
. A. Major pathways in retinoid metabolism. In the intestine, retinoids and carotenoids taken in the diet (from animal and vegetable sources, respectively) are mainly converted to REs, which are incorporated into chylomicrons and taken to the liver ...
Maria Armanda Reis-Henriques (172828), Manuel Gesto (172822), L. Filipe C. Castro (9371), Miguel Machado Santos (172833)   +3 more
core   +1 more source

Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21 [PDF]

, 2009
OBJECTIVE—Fibroblast growth factor (FGF)-21 improves insulin sensitivity and lipid metabolism in obese or diabetic animal models, while human studies revealed increased FGF-21 levels in obesity and type 2 diabetes.
Pfeiffer, Andreas F. H., Meinus, S., Andres, Janin, Biedasek, Katrin, Biedasek, K., Spranger, J., Mai, K., Reinecke, F., Spuler, S., Pfeiffer, A.F., Moehlig, M., Sabath, Markus, Clemenz, M., Mai, Knut, Bobbert, T., Meinus, Sabine, Spranger, Joachim, Reinecke, Franziska, Weickert, Martin O., Bobbert, Thomas, Weicht, J., Möhlig, Matthias, Andres, J., Weicht, Jessica, Kintscher, U., Spuler, Simone, Clemenz, Markus, Sabath, M., Weickert, M.O., Kintscher, Ulrich   +29 more
core   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik, Asuman Deveci Ozkan, Tuğba Kotil, Nazan Deniz Yön   +3 more
wiley   +1 more source