Results 41 to 50 of about 905,398 (250)

An LC/MS method for d8-β-carotene and d4-retinyl esters: β-carotene absorption and its conversion to vitamin A in humans

Journal of Lipid Research, 2012
The intestinal absorption and metabolism of β-carotene is of vital importance in humans, especially in populations that obtain the majority of their vitamin A from provitamin A carotenoids.
Matthew K. Fleshman, Ken M. Riedl, Janet A. Novotny, Steven J. Schwartz, Earl H. Harrison   +4 more
doaj   +1 more source

Retinoids in the visual cycle: role of the retinal G protein-coupled receptor

Journal of Lipid Research, 2021
Driven by the energy of a photon, the visual pigments in rod and cone photoreceptor cells isomerize 11-cis-retinal to the all-trans configuration.
Elliot H. Choi, Anahita Daruwalla, Susie Suh, Henri Leinonen, Krzysztof Palczewski   +4 more
doaj   +1 more source

RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells

Journal of Lipid Research, 2013
All-trans retinoic acid (ATRA) has a key role in dendritic cells (DCs) and affects T cell subtype specification and gut homing. However, the identity of the permissive cell types and the required steps of conversion of vitamin A to biologically active ...
Adrienn Gyöngyösi, Istvan Szatmari, Attila Pap, Balazs Dezső, Zoltan Pos, Lajos Széles, Tamas Varga, Laszlo Nagy   +7 more
doaj   +1 more source

Disruption of androgen metabolism, regulation and effects : involvement of steroidogenic enzymes [PDF]

, 2014
Communication between organs and tissues is predominately controlled by hormones. Hormones regulate a vast variety of physiological and behavioural activities, including metabolism, growth and development, reproduction, sleep and mood.
Fürstenberger, Cornelia
core   +1 more source

Single-Cell Analysis Reveals Regional Reprogramming During Adaptation to Massive Small Bowel Resection in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: The small intestine (SI) displays regionality in nutrient and immunological function. Following SI tissue loss (as occurs in short gut syndrome, or SGS), remaining SI must compensate, or “adapt”; the capacity of SI epithelium to ...
Kristen M. Seiler, Sarah E. Waye, Wenjun Kong, Kenji Kamimoto, Adam Bajinting, William H. Goo, Emily J. Onufer, Cathleen Courtney, Jun Guo, Brad W. Warner, Samantha A. Morris   +10 more
doaj   +1 more source

Hepatic metabolism of retinoids and disease associations [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
The liver is the most important tissue site in the body for uptake of postprandial retinoid, as well as for retinoid storage. Within the liver, both hepatocytes and hepatic stellate cells (HSCs) are importantly involved in retinoid metabolism. Hepatocytes play an indispensable role in uptake and processing of dietary retinoid into the liver, and in ...
Yohei, Shirakami, Seung-Ah, Lee, Robin D, Clugston, William S, Blaner   +3 more
openaire   +2 more sources

Enzymology of retinoic acid biosynthesis and degradation

Journal of Lipid Research, 2013
All-trans-retinoic acid is a biologically active derivative of vitamin A that regulates numerous physiological processes. The concentration of retinoic acid in the cells is tightly regulated, but the exact mechanisms responsible for this regulation are ...
Natalia Y. Kedishvili
doaj   +1 more source

The Biological Effects of Novel Synthetic Retinoids [PDF]

, 2010
Naturally occurring Retinoids are known to play a role in many developmental processes in the early embryo as well as being a potent tool for in vitro differentiation of stem cells. The exogenous application of these naturally occurring retinoids as well
BUDGE, JAMES,JOHN,ROWLAND
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells?

Biomolecules, 2021
Congenital PAX6-aniridia is a rare panocular disease resulting from limbal stem cell deficiency. In PAX6-aniridia, the downregulation of the retinol-metabolizing enzymes ADH7 (All-trans-retinol dehydrogenase 7) and ALDH1A1/A3 (Retinal dehydrogenase 1 ...
Lorenz Latta, Igor Knebel, Constanze Bleil, Tanja Stachon, Priya Katiyar, Claire Zussy, Fabian Norbert Fries, Barbara Käsmann-Kellner, Berthold Seitz, Nóra Szentmáry   +9 more
doaj   +1 more source