Results 151 to 160 of about 14,401 (197)

Reduced Esterification Rather Than Increased Hydrolysis Is Causative for Loss of Hepatic Retinoids Upon CCl₄-Induced Liver Injury. [PDF]

Liver Int
Wagner C, Košić K, Bulfon D, Breithofer J, Jamnik A, Zitta C, Horvat P, Bilweis K, Schupp M, Zimmermann R, Taschler U, Lass A.   +11 more
europepmc   +1 more source

Exploring the Therapeutic Potential of Antidiabetic Drugs in Cardiac Arrhythmia Management: A Drug Target Mendelian Randomization Study. [PDF]

J Arrhythm
Song ZQ, Zhou ZB, Wang BX, Wu SK, Sun YH, Chen YH, Feng SY, Sun RF.   +7 more
europepmc   +1 more source

Orphan Nuclear Receptors in Metabolic Dysfunction-associated Steatotic Liver Disease Development. [PDF]

J Clin Transl Hepatol
Li H, Chen J, Huang Z, Chen M.
europepmc   +1 more source

Liquid Crystal Monomers and Their Mixtures Alter Nuclear Receptor Signaling and Promote Adipogenesis In Vitro.

Endocrinology
Heldman SM, Eccles KM, Kassotis CD.
europepmc   +1 more source

A Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neurons, Glia and Microglia Cells In Vitro. [PDF]

Int J Mol Sci
Zhang Y, Gailloud L, Shin A, Fewkes J, Pinckney R, Whiting A, Chazot P.   +6 more
europepmc   +1 more source

Blood and adipose tissue DNA methylation in adults born preterm with a very low birth weight - a sibling comparison study. [PDF]

Epigenomics
Hauta-Alus HH, Ronkainen J, Kuula J, Czamara D, Heiskala A, Sandboge S, Björkqvist J, Kaseva N, Räikkönen K, Pietiläinen KH, Sebert S, Kajantie E.   +11 more
europepmc   +1 more source

Classification of Paediatric Celiac Disease Using RNA Sequencing and Real-Time PCR of Duodenal Biomarkers. [PDF]

J Cell Mol Med
Bragde HG, Almer S, Söderman J.
europepmc   +1 more source

Exploration of the potential mechanism of cyclolinopeptides-mediated antiosteoporosis effects via network pharmacology analysis. [PDF]

BMC Complement Med Ther
Xiao Y, Wang R, Long Y, Xie J, Cai Z, Lai Z, Zhao J, Wang Y, Nie H.   +8 more
europepmc   +1 more source

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Rexinoid inhibits Nrf2-mediated transcription through retinoid X receptor alpha

Biochemical and Biophysical Research Communications, 2014
NF-E2 P45-related factor 2 (Nrf2) is a key transcription factor that controls genes encoding cytoprotective and detoxifying enzymes through antioxidant response elements (AREs) in their regulatory regions. We reported recently that retinoid X receptor alpha (RXRα) inhibits Nrf2 function by direct interaction with the Neh7 domain of Nrf2 in a ligand ...
Jiaguo, Wu, Hongyan, Wang, Xiuwen, Tang
openaire   +2 more sources

Structure-Based Design of Potent Retinoid X Receptor α Agonists

Journal of Medicinal Chemistry, 2004
A series of tetrahydrobenzofuranyl and tetrahydrobenzothienyl propenoic acids that showed potent agonist activity against RXRalpha were synthesized via a structure-based design approach. Among the compounds studied, 46a,b showed not only very good potency against RXRalpha (K(i) = 6 nM) but was also found to be greater than 167-fold selective vs ...
Curt D, Haffner, James M, Lenhard, Aaron B, Miller, Darryl L, McDougald, Kate, Dwornik, Olivia R, Ittoop, Robert T, Gampe, H Eric, Xu, Steve, Blanchard, Valerie G, Montana, Tom G, Consler, Randy K, Bledsoe, Andrea, Ayscue, Dallas, Croom   +13 more
openaire   +2 more sources