Results 161 to 170 of about 14,401 (197)

Involvement of Retinoid X Receptor α in Coenzyme Q Metabolism

Journal of Molecular Biology, 2003
The nuclear retinoid X receptor alpha (RXRalpha) is the heterodimer partner in several nuclear receptors, some of them regulating lipid biosynthesis. Since coenzyme Q (CoQ) levels are greatly modified in aging and a number of diseases, we have investigated the involvement of RXRalpha in the biosynthetic regulation of this lipid by using a hepatocyte ...
Magnus, Bentinger, Mikael, Turunen, Xiao-Xue, Zhang, Yu-Jui Yvonne, Wan, Gustav, Dallner   +4 more
openaire   +2 more sources

Identification and characterization of the human retinoid X receptor alpha gene promoter

Gene, 2006
Retinoid X receptors (RXRs) comprise a family of nuclear retinoid activated transcription factors that are members of the steroid hormone receptor superfamily. RXRs are obligate heterodimerization partners with several other hormone receptor family members, making them critical mediators of a wide range of signaling pathways.
Guojun, Li, Weihong, Yin, Robert, Chamberlain, David, Hewett-Emmett, Jennifer N, Roberts, Xiulan, Yang, Scott M, Lippman, John L, Clifford   +7 more
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Localization of the retinoid X receptor alpha gene (RXRA) to chromosome 9q34

Annals of Human Genetics, 1993
SummaryThe retinoid X receptor α is one of a number of retinoic acid receptors which are members of the steroid/thyroid hormone superfamily. Localization of RXRA was achieved using the polymerase chain reaction on a panel of somatic cell hybrids. A cosmid clone was isolated using the RXRA PCR product, and this was used to further localize the gene by ...
K A, Jones, J, Fitzgibbon, K J, Woodward, D, Goudie, M A, Ferguson-Smith, S, Povey, J, Wolfe, E, Solomon   +7 more
openaire   +2 more sources

Predictive Impact of Retinoid X Receptor-Alpha-Expression in Renal-Cell Carcinoma

Cancer Biotherapy and Radiopharmaceuticals, 2004
Retinoid receptors are nuclear transcription factors that mediate the effects of retinoids on gene expression. In our study, we analyzed the expression of retinoid X receptor-alpha (RXR-alpha) and its prognostic value in renal-cell carcinoma (RCC) patients exhibiting stage IV disease upon first diagnosis or thereafter.Detection of RXR-alpha was ...
Nicole, Buentig, Stefan, Stoerkel, Eve, Richter, Iris, Dallmann, Martina, Reitz, Jens, Atzpodien   +5 more
openaire   +2 more sources

Retinoid-X-receptor alpha (RXRα) expression during laryngeal carcinogenesis: Detrimental or beneficial event?

Cancer Letters, 2003
RXRalpha is an obligatory heterodimerization partner in many signal transducing pathways. To evaluate RXRalpha expression during laryngeal carcinogenesis, immunohistochemistry was performed on laryngeal epithelial specimens of 154 patients with normal-appearing, hyperplastic, dysplastic laryngeal epithelium and squamous cell carcinoma.
Michalis V, Karamouzis, Georgia, Sotiropoulou-Bonikou, Gerasimos, Vandoros, Ioannis, Varakis, Athanasios G, Papavassiliou   +4 more
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The Role of Retinoid X Receptor α in Regulating Alcohol Metabolism

The Journal of Pharmacology and Experimental Therapeutics, 2006
There is substantial overlap in retinol and alcohol metabolism. Mice that lack retinoic acid (RA) receptor retinoid X receptor alpha (RXRalpha) expression in the liver are more susceptible to alcoholic liver disease. To investigate the interaction between RXRalpha and alcoholic liver disease, ethanol metabolism was studied in hepatocyte RXRalpha ...
Maxwell Afari, Gyamfi, Michael George, Kocsis, Lin, He, Guoli, Dai, Alphonse John, Mendy, Yu-Jui Yvonne, Wan   +5 more
openaire   +2 more sources

Sequence requirements for high affinity retinoid X receptor-α homodimer binding

Molecular and Cellular Endocrinology, 1996
To better delineate the sequence requirements for high affinity binding of retinoid X receptor alpha (RXR alpha) homodimers, a selection protocol was used starting from a random pool of oligonucleotides. All recovered sequences contained at least two hexamers related to the consensus sequence for the thyroid/retinoid subfamily of nuclear receptors, A ...
H, Castelein, A, Janssen, P E, Declercq, M, Baes   +3 more
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Analysis of Vitamin D-receptor (VDR) and Retinoid X-receptor α in Breast Cancer

The Histochemical Journal, 2002
The expression of vitamin D-receptor (VDR) and retinoid X-receptor alpha (RXR-alpha) has been analysed immunohistochemically in benign (n = 62 and n = 5 respectively) and malignant (n = 228 and n = 15 respectively) breast tissue samples using a monoclonal antibody 9A7gamma against VDR and a polyclonal antibody against RXR-alpha.
Michael, Friedrich, Roland, Axt-Fliedner, Carlos, Villena-Heinsen, Wolfgang, Tilgen, Werner, Schmidt, Jörg, Reichrath   +5 more
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Expression of Retinoid X Receptor α Is Increased upon Monocytic Cell Differentiation

Biochemical and Biophysical Research Communications, 1996
1 alpha, 25-Dihydroxyvitamin D3 (VD) is a potent inducer of monocytic differentiation of both normal and leukemic cells. Its effects are mediated by its nuclear receptor (VDR). Efficient gene activation requires the heterodimerization of VDR with Retinoid X Receptors (RXR).
H, Defacque, T, Commes, E, Legouffe, C, Sevilla, J F, Rossi, C, Rochette-Egly, J, Marti   +6 more
openaire   +2 more sources

Peroxisome proliferator-activated receptor-α and retinoid X receptor agonists inhibit inflammatory responses of astrocytes

Journal of Neuroimmunology, 2006
The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR-alpha agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).
Jihong, Xu, Janet A, Chavis, Michael K, Racke, Paul D, Drew   +3 more
openaire   +2 more sources