Results 71 to 80 of about 14,401 (197)

Prioritising research on endocrine disruption in the marine environment: a global perspective

Biological Reviews, EarlyView.
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto, Angelica Miglioli, Carlie A. LaLone, Lisa Baumann, Alice Baynes, Mélanie Blanc‐Legendre, Ibon Cancio, Xavier Cousin, ZhiChao Dang, Rémi Dumollard, Alex T. Ford, Christopher Green, Taisen Iguchi, Philippa Kearney, Thomas Knigge, Christophe Minier, Tiphaine Monsinjon, Marta S. Monteiro, Joachim Sturve, Haruna Watanabe, Hiroshi Yamamoto, Gerald Ankley, Deborah M. Power, Ioanna Katsiadaki   +23 more
wiley   +1 more source

Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation

BMC Biology, 2023
Background The maturation of microRNAs (miRNAs) successively undergoes Drosha, Dicer, and Argonaute ˗mediated processing, however, the intricate regulations of the individual miRNA maturation are largely unknown.
Xiaohong Ye, Yun Yang, Jiayue Yao, Mo Wang, Yixin Liu, Guobin Xie, Zhiping Zeng, Xiao-kun Zhang, Hu Zhou   +8 more
doaj   +1 more source

Differentiating solar lentigines from post‐inflammatory hyperpigmentation with hyperspectral imaging: A pilot study

International Journal of Cosmetic Science, EarlyView.
This preliminary study attempted to characterize solar lentigines and post‐inflammatory hyperpigmentation (PIH) observed on Japanese women. Colorimetric features and chromophore concentrations were measured using hyperspectral imaging for each hyperpigmentation type.
Victor Egana, Carl Blaksley, Ayako Itaya, Mai Edagawa, Alexandre Nicolas   +4 more
wiley   +1 more source

Hypothyroidism Side Effect in Patients Treated with Sunitinib or Sorafenib: Clinical and Structural Analyses. [PDF]

PLoS ONE, 2016
Tyrosine kinase inhibitors (TKIs) provide more effective targeted treatments for cancer, but are subject to a variety of adverse effects, such as hypothyroidism. TKI-induced hypothyroidism is a highly complicated issue, because of not only the unrealized
Mao Shu, Xiaoli Zai, Beina Zhang, Rui Wang, Zhihua Lin   +4 more
doaj   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Gene Expression Patterns Associated with Peroxisome Proliferator-activated Receptor (PPAR) Signaling in the of Hanwoo (Korean Cattle) [PDF]

Asian-Australasian Journal of Animal Sciences, 2015
Adipose tissue deposited within muscle fibers, known as intramuscular fat (IMF or marbling), is a major determinant of meat quality and thereby affects its economic value. The biological mechanisms that determine IMF content are therefore of interest. In
Dajeong Lim, Han-Ha Chai, Seung-Hwan Lee, Yong-Min Cho, Jung-Woo Choi, Nam-Kuk Kim   +5 more
doaj   +1 more source

Erythrokeratodermia‐Cardiomyopathy Syndrome: Expanding the DSP Mutational Spectrum Beyond Proline Substitutions

Pediatric Dermatology, EarlyView.
ABSTRACT Erythrokeratodermia cardiomyopathy (EKC) syndrome is a rare autosomal dominant disorder characterized by generalized erythrokeratoderma and progressive dilated cardiomyopathy, caused by pathogenic variants in the SR6 domain of desmoplakin (DSP).
Sepideh Hamzehlou, Ryland D. Mortlock, Caroline Echeandia‐Francis, Jing Zhou, Chao Xing, Nnenna G. Agim, Keith A. Choate, Donald A. Glass II   +7 more
wiley   +1 more source

Ligand-Independent Coregulator Recruitment by the Triply Activatable OR1/Retinoid X Receptor-α Nuclear Receptor Heterodimer [PDF]

Molecular Endocrinology, 1999
OR1 is a member of the superfamily of steroid/thyroid hormone nuclear receptors and recognizes DNA as a heterodimer with the 9-cis-retinoic acid receptor RXR (retinoid X receptor). The heterodimeric complex has been shown to be transcriptionally activatable by the RXR ligand as well as certain oxysterols via OR1, but to date uniquely also by ...
F F, Wiebel, K R, Steffensen, E, Treuter, D, Feltkamp, J A, Gustafsson   +4 more
openaire   +2 more sources

Immunomodulatory effects of cathelicidin in the gut–brain axis: A novel link between mucosal immunity and neuroinflammation

Experimental Physiology, EarlyView.
Abstract Cathelicidins are evolutionarily conserved host defence peptides known for their dual antimicrobial and immunomodulatory functions. Among them, LL‐37 in humans and CRAMP in rodents have emerged as crucial regulators of both mucosal immunity and CNS inflammation.
Mehrdad Nourizadeh, Amir Arsalan Ghahari, Ehsan Zandi, Seyedeh Zeynab Rasouli, Shaghayegh Davari, Mobina Hoseinzadeh, Mir Alireza Nourazar   +6 more
wiley   +1 more source

BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination

JCI Insight, 2021
Activation of farnesoid X receptor (FXR) by obeticholic acid (OCA) reduces hepatic inflammation and fibrosis in patients with primary biliary cholangitis (PBC), a life-threatening cholestatic liver failure. Inhibition of bromodomain-containing protein 4 (
Hyunkyung Jung, Jinjing Chen, Xiangming Hu, Hao Sun, Shwu-Yuan Wu, Cheng-Ming Chiang, Byron Kemper, Lin-Feng Chen, Jongsook Kim Kemper   +8 more
doaj   +1 more source