Results 91 to 100 of about 16,489,844 (222)

In vitro interaction of fenretinide with plasma retinol-binding protein and its functional consequences [PDF]

, 1992
The synthetic retinoid fenretinide (4-HPR; N-[4-hydroxyphenyl] all-trans-retinamide) interacts with plasma apo-retinol-binding protein (RBP)to form a tight complex (λHJ = 0.2 μM) which does not exhibit binding affinity to transthyretin (TTR).
Rodolfo Berni, Formelli, Franca, FORMELLI F., Berni, Rodolfo, Franca Formelli   +4 more
core   +1 more source

Retinol Binding Protein 4 (RBP4) in Adipocytes and Obesity

The FASEB Journal, 2019
We have earlier reported the generation and study of transgenic mice that express human RBP4 (hRBP4) in both white and brown adipocytes (Lee et al. Hepatology 2016, 64:1534–1546). Our published studies of these mice (adi‐hRBP4 mice) established that
Igor Shmarakov, Seung‐Ah Lee, William S. Blaner   +2 more
openaire   +1 more source

Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study

Lipids in Health and Disease, 2011
Background The kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin.
Henze Andrea, Raila Jens, Kempf Caroline, Reinke Petra, Sefrin Anett, Querfeld Uwe, Schweigert Florian J   +6 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Retinol-induced secretion of human retinol-binding protein in yeast [PDF]

, 1998
Retinol-binding protein (RBP) functions as a transporter for retinol (vitamin A) in plasma in higher eukaryotes. We have successfully expressed human RBP in Saccharomyces cerevisiae, and its secretion was found to be induced by retinol also in this lower
Sigbjørn Smeland, Sjur Reppe, Moskaug, Jan Ø, Reppe, Sjur, Rune Blomhoff, Smeland, Sigbjørn, Blomhoff, Rune, Jan Ø Moskaug   +7 more
core   +1 more source

Polyphenol dietary supplementation prevents inflammation‐induced muscle atrophy in a zebrafish (Danio rerio) model

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Diet‐induced inflammation is a major cause of muscle degeneration impacting human and animal health. Owing to their anti‐inflammatory and antioxidant properties, polyphenols have attracted considerable interest as feed additives.
Graziella Orso, Monica Matuozzo, Mariapina Rocco, Seyed Hossein Hoseinifar, Ghasem Ashouri, Andrea Scaloni, Marina Paolucci, Chiara D'Ambrosio, Roberta Imperatore   +8 more
wiley   +1 more source

Retinol Modulates Site-Specific Mobility of Apo-Cellular Retinol-Binding Protein to Promote Ligand Binding

, 2016
A fundamental question in protein science is how the inherent dynamics of a protein influence its function. If this function involves interactions with a ligand, the protein−ligand encounter has the potential to modulate the protein dynamics.
Davide Cavazzini (2533249), Gian Luigi Rossi (2154232), Brian Schaffhausen (2533255), Ulrich L. Günther (1263546), Lorella Franzoni (2533246), Tanja Mittag (2533252)   +5 more
core   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Serum Retinol-Binding Protein 4 as a Marker for Cardiovascular Disease in Women

PLoS ONE, 2012
Elevated serum level of retinol-binding protein 4 (RBP4) has been associated with obesity-related co-morbidities including insulin resistance, dyslipidemia and hypertension.The present study examined the relationship between serum level of RBP4 and various risk factors related to cardiovascular disease (CVD) in men and women.284 subjects (139 males ...
Al-Daghri, NM, Alkharfy, KM, Vanhoutte, PMGR, Krishnaswamy, S, Xu, A   +4 more
openaire   +5 more sources