Results 91 to 100 of about 40,792 (218)

Review Article: Renal Safety Profiles of Tenofovir Alafenamide, Tenofovir Disoproxil Fumarate, and Entecavir for the Treatment of Chronic Hepatitis B Infection—General and Special Populations

open access: yesAlimentary Pharmacology &Therapeutics, Volume 63, Issue 7, Page 945-954, April 2026.
Current first‐line NUCs show comparable renal safety profiles in CHB patients with no or mild kidney dysfunction, with growing evidence that favours TAF. Future prospective studies are needed to validate these findings, and more research should focus on CHB patients with diabetes mellitus who are at risk of CKD.
Lung‐Yi Mak   +2 more
wiley   +1 more source

Taste Preferences Shape Disease Susceptibility via Heritable Nutrient Predispositions: A Behavior–Gene Coevolution Framework

open access: yesGenes, Brain and Behavior, Volume 25, Issue 2, April 2026.
Environmental selection pressures, consistent with the evolutionary principle of survival of the fittest, shaped ancestral dietary behavior and taste preferences; intergenerational adaptations along the brain–gut axis, together with genetic polymorphisms, have left an imprint on tendencies to enrich or clear particular nutrients.
Xinyang Yan   +4 more
wiley   +1 more source

Single Cell Analysis Reveals the Presence of Novel Intermediate Cells in Both Mice and Patients With Severe MASLD

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Schematic overview of the experimental workflow combining single‐cell RNA sequencing and spatial proteomics in a murine model of MASLD. Tissues were isolated, dissociated, and processed for single‐cell transcriptomic profiling to identify distinct cellular clusters and define cell‐type–specific gene expression signatures. Computational analysis enabled
Marica Meroni   +18 more
wiley   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen   +14 more
wiley   +1 more source

Influência da idade gestacional e da paridade sobre a concentração de retinol no colostro humano Influence of gestational age and parity on the concentration of retinol in human colostrums

open access: yesArchivos Latinoamericanos de Nutrición, 2010
A vitamina A é particularmente importante durante os períodos críticos de crescimento, proliferação e desenvolvimento dos tecidos como gestação, período neonatal e infância.
Roberto Dimenstein   +3 more
doaj  

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He   +7 more
wiley   +1 more source

Exploring the Anti‐Diabetic Potential of Anthocyanins: From Biochemical Pathways to Human Trials

open access: yesChronic Diseases and Translational Medicine, Volume 12, Issue 1, Page 1-15, March 2026.
ABSTRACT Diabetes mellitus (DM) is a global health challenge with increasing prevalence rates, particularly in low‐ and middle‐income countries. Anthocyanins (ACs) are potential bioactive compounds found in various fruits and vegetables, attracting the attention of researchers due to their possible role in managing diabetes and its complications ...
Lakshay Panchal   +6 more
wiley   +1 more source

Association between dietary retinol intake and rheumatoid arthritis based on NHANES database

open access: yesBMC Public Health
Objective This study focused on the investigation of the correlation between dietary retinol intake and rheumatoid arthritis (RA) using the National Health and Nutrition Examination Survey (NHANES) database. Methods Data from five NHANES cycles from 2003
Yuexin Ni   +3 more
doaj   +1 more source

Inflammation in Idiopathic Intracranial Hypertension: An Immunometabolic Mechanistic Framework and Clinical Implications

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Systemic metabolic dysfunction and comorbidities may act as upstream modulators converging on inflammatory activation, which is closely intertwined with excessive CSF production and impaired clearance, potentially contributing to sustained ICP elevation.
Guangyu Han   +5 more
wiley   +1 more source

Transcriptome–Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass‐Specific Phenotypes

open access: yesEuropean Journal of Immunology, Volume 56, Issue 3, March 2026.
We performed combined proteome and transcriptome analysis of human isotype‐defined B cell subsets. IgG4‐switched B cells were most distinct from naive B cells in terms of mRNA as well as protein expression profiles. SDR16C5 was identified as uniquely upregulated in IgG4‐switched B cells.
Jana Koers   +6 more
wiley   +1 more source

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