Results 161 to 170 of about 58,345 (262)

Effects of CYP2E1 Polymorphism and Dietary Supplementation With Jerusalem Artichoke on Skatole and Indole Levels in the Back Fat and Feces of Boars, and Liver mRNA Expression

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This study investigated the combined effects of CYP2E1 gene polymorphism (SNP NM_214421.1: c.1423G > A) and short‐term dietary supplementation with Jerusalem artichoke (Helianthus tuberosus, 8.2% tuber meal) on skatole and indole concentrations in back fat and feces of 25 crossbreed boars, and on hepatic CYP2E1 mRNA expression. Animals were assigned to
Kateřina Zadinová, Antonín Stratil, Jaroslav Čítek, Monika Okrouhlá, Jan Calta, Ivan Bahelka, Kateřina Urbancová, Michal Šprysl, Roman Stupka   +8 more
wiley   +1 more source

Calpeptin Reduces Extracellular Vesicle Secretion and Induces Anti‐Inflammatory Effects but Upregulates HO‐1 and Alters Adiponectin Levels in Human Adipocytes

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Recent studies have shown that adipose tissue (AT) secretes elevated levels of extracellular vesicles (EVs) in obesity, and these EVs play roles in metabolic diseases. The inhibition of calpains has anti‐inflammatory and anti‐fibrotic effects on AT in mice and reduces EV secretion in some cell types in vitro.
Johanna Matilainen, Sanni Foster, Viivi Berg, Janne Tampio, Tanja Turunen, Anne‐Mari Mustonen, Heikki Kyykallio, Maija Vaittinen, Ville Männistö, Jussi Pihlajamäki, Marjo Malinen, Sanna Oikari, Pirjo Käkelä, Dorota Kaminska, Veera Luukkonen, Kristiina M. Huttunen, Martin Wabitsch, Petteri Nieminen, Kirsi Rilla   +18 more
wiley   +1 more source

Bioconversion of β-carotene to vitamin A across life stages using stable isotope methodologies: a protocol for the systematic review. [PDF]

Syst Rev
Frane RD, Lat HT, Semilla JJL, Diaz JMS, Zumaraga MPP.   +4 more
europepmc   +1 more source

Systematic Analysis of Plasma‐Derived Extracellular Vesicle‐Enriched Samples in Age‐Related Macular Degeneration Reveals Oxidative Stress Linked to Altered Lipid and Protein Profiles

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Vision impairment caused by age‐related macular degeneration (AMD) is a global health priority. Retinal pathology is driven by ageing and exacerbated by genetic and environmental risk factors. Peripheral blood circulation is increasingly recognised as a contributor to disease initiation and progression, and a source of biomarkers to support ...
Marzena Kurzawa‐Akanbi, Jennifer Haggarty, Carina Hansohn, Mohamed T. Patel, Angela J. Cree, Peisi Teo, Milly Armstrong, Nathan Coles, Mark Platt, Helen Griffiths, Heather J. Cordell, Ahmad Khundakar, Pola Goldberg Oppenheimer, Phillip Whitfield, Andrew Lotery, Henning Urlaub, Sina Mozaffari‐Jovin, Majlinda Lako   +17 more
wiley   +1 more source

Astaxanthin Alleviates Intestinal Ferroptosis through Gut Commensal <i>Lepagella muris</i>-Mediated Retinoic Acid Production and SLC7A11 Activation. [PDF]

Research (Wash D C)
Liu S, Huang L, Xiao S, Li Y, Luo S, Hou E, Zhang Y, Jin M, Wang Y, Zong X.   +9 more
europepmc   +1 more source

Integrative Multi‐Omics Mendelian Randomization Analysis Identifies NIT2 as a Potential Metabolic Risk Gene in Hepatocellular Carcinoma

The Journal of Gene Medicine, Volume 28, Issue 9, September 2026.
Metabolic dysregulation plays an important role in hepatocellular carcinoma (HCC), but causal metabolic genes remain poorly defined. We integrated transcriptomic, methylation, expression, and protein quantitative trait loci data using summary data‐based Mendelian Randomization and colocalization analyses to identify causal metabolism‐related genes ...
Ziyue Liao, Qinghua Fang, Yue Chen, Xiangyu Yang, Haijuan Wu, Hongyang Wang, Jian Gao   +6 more
wiley   +1 more source

Key molecular networks underlying retinol's biphasic effects on cell proliferation through multi-omics integrative analysis using genome-scale metabolic modeling. [PDF]

Synth Syst Biotechnol
He P, Xiang G, Yan Y, Zhong J, Liang Y, Shu P, Lu H.   +6 more
europepmc   +1 more source

Proteo‐Metabolomic Profiling of PMM2‐CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo‐Inositol, and the Hexosamine Pathway

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways, the functional consequences of these alterations remain poorly understood.
Diana Gallego, Giuseppina Andreotti, Maria Monticelli, Debora Paris, Arturo Martín‐Martínez, Alejandra Gámez, Mercedes Serrano, José Córdoba‐Caballero, Pedro Seoane, Juan A. G. Ranea, Belén Pérez   +10 more
wiley   +1 more source

Maternal vitamin A levels during second and third trimester and associations with offspring's birth weight: a longitudinal cohort <i>post-hoc</i> study. [PDF]

Front Nutr
Dirnena-Fusini I, Stafne SN, Gustafsson MK, Mosti MP, Sujan MAJ, Syversen U, Stunes AK.   +6 more
europepmc   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source