Transthyretin and Vitamin A Metabolism: A Review for the Cardiac Amyloidosis Specialist. [PDF]
J Cardiovasc Dev DisTransthyretin (TTR) amyloidosis is a systemic, progressive, and fatal disease. TTR is integral in vitamin A (retinol) transport via its binding to retinol binding protein 4 (RBP4).
Brown D +4 more
europepmc +2 more sources
Retinol tracing within murine neural retina reveals cell type-specific retinol transport and distribution. [PDF]
J Clin Invest11-cis-Retinal is essential for light perception in mammalian photoreceptors (PRs), and aberrations in retinoid transformations cause severe retinal diseases. Understanding these processes is crucial for combating blinding diseases.
Engfer ZJ +12 more
europepmc +2 more sources
Serum Amyloid a Is a Retinol Binding Protein That Transports Retinol During Bacterial Infection.
ELife, 2014 Retinol plays a vital role in the immune response to infection, yet proteins that mediate retinol transport during infection have not been identified.
Sureka Gattu +2 more
exaly +3 more sources
Maternal obesity remodels nutrient transport transcriptional programs in early mouse embryonic and extraembryonic cell lineages. [PDF]
Mol MetabBackground: Maternal obesity increases the risk of congenital anomalies and later-life metabolic disease in offspring. Still, underlying mechanisms remain unclear, particularly in extraembryonic lineages at the maternal–fetal interface, which remain ...
Caballero A, Chi L, Delgado-Olguín P.
europepmc +2 more sources
Severe dengue in children associates with dysregulation of lipid homeostasis, complement cascade and retinol transport. [PDF]
Clin Transl Med, 2023 Panwar A +11 more
europepmc +2 more sources
Beyond a gatekeeper: the non-classical signaling role of STRA6 in driving endothelial senescence and atherosclerosis. [PDF]
Front ImmunolEndothelial cell (EC) senescence is a fundamental driver of atherosclerosis. This review posits that the primary pathogenic role of Stimulated by Retinoic Acid 6 (STRA6) in the endothelium is not its canonical vitamin A transport but its non-classical ...
Yuan Y +7 more
europepmc +2 more sources
Biological Functions of RBP4 and Its Relevance for Human Diseases
Frontiers in Physiology, 2021 Retinol binding protein 4 (RBP4) is a member of the lipocalin family and the major transport protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation.
Julia S. Steinhoff +3 more
doaj +1 more source
An in vitro model for vitamin A transport across the human blood–brain barrier
eLife, 2023 Vitamin A, supplied by the diet, is critical for brain health, but little is known about its delivery across the blood–brain barrier (BBB). Brain microvascular endothelial-like cells (BMECs) differentiated from human-derived induced pluripotent stem ...
Chandler B Est, Regina M Murphy
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Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis
Molecular Metabolism, 2020 Objective: Transformation of white into brown fat (“browning”) reduces obesity in many preclinical models and holds great promise as a therapeutic concept in metabolic disease. Vitamin A metabolites (retinoids) have been linked to thermogenic programming
Anna Fenzl +11 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 The distribution of dietary vitamin A/all-trans retinol/ROL throughout the body is critical for maintaining retinoid function in peripheral tissues and for retinoid delivery to the eye in the support of visual function.
Rakesh Radhakrishnan +5 more
doaj +1 more source