Results 21 to 30 of about 14,996 (210)

Histopathological Characteristics and Multi-Omics Analysis of Ocular Pigmentation Defects in Albino Percocypris pingi [PDF]

Cells
Percocypris pingi was listed in the China Vertebrate Red List in 2015, and albino P. pingi exhibits remarkable ocular phenotypes due to melanin synthesis defects, including the deficiency of melanin granules in the iris and retinal pigment epithelium ...
Senyue Liu, Xiaoyun Wu, Qiaolin Zou, Jiansheng Lai, Yongqiang Deng, Yang Feng, Chengyan Mou, Mingjiang Song, Pengcheng Li, Jun Du, Yan Liu, Qiang Li, Ya Liu   +12 more
doaj   +2 more sources

Severe dengue in children associates with dysregulation of lipid homeostasis, complement cascade and retinol transport [PDF]

Clinical and Translational Medicine, 2023
Aleksha Panwar, Rinki Kumar, Renu Goel, Suruchi Aggarwal, Shweta Saraswat, Priyanka Bansal, Zaozianlungliu Gonmei, Gurudyal Toteja, Amit Yadav, Rakesh Lodha, Nirpendra Singh, Guruprasad Medigeshi   +11 more
doaj   +2 more sources

Biological Functions of RBP4 and Its Relevance for Human Diseases

Frontiers in Physiology, 2021
Retinol binding protein 4 (RBP4) is a member of the lipocalin family and the major transport protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation.
Julia S. Steinhoff, Achim Lass, Achim Lass, Michael Schupp   +3 more
doaj   +1 more source

The transport of retinol in human plasma [PDF]

FEBS Letters, 1969
Evidence in support of the view that tryptophanrich prealbumin [l] may serve as the specific transport protein for retinol in human plasma has previously been reported by Alvsaker, Haugli and Laland [2]. Since thyroxine is transported partly by this protein [3] , thyroxine and retinol would then share the same transport protein. In order to investigate
Johannessen, S., Alvsaker, J.O., Laland, S.G.   +2 more
openaire   +2 more sources

An in vitro model for vitamin A transport across the human blood–brain barrier

eLife, 2023
Vitamin A, supplied by the diet, is critical for brain health, but little is known about its delivery across the blood–brain barrier (BBB). Brain microvascular endothelial-like cells (BMECs) differentiated from human-derived induced pluripotent stem ...
Chandler B Est, Regina M Murphy
doaj   +1 more source

Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis

Molecular Metabolism, 2020
Objective: Transformation of white into brown fat (“browning”) reduces obesity in many preclinical models and holds great promise as a therapeutic concept in metabolic disease. Vitamin A metabolites (retinoids) have been linked to thermogenic programming
Anna Fenzl, Oana Cristina Kulterer, Katrin Spirk, Goran Mitulović, Rodrig Marculescu, Martin Bilban, Sabina Baumgartner-Parzer, Alexandra Kautzky-Willer, Lukas Kenner, Jorge Plutzky, Loredana Quadro, Florian W. Kiefer   +11 more
doaj   +1 more source

Transport of retinol in the duck plasma [PDF]

Journal of Biosciences, 1981
Retinol-binding protein and prealbumin were isolated from duck plasma by chromatography on DEAE-cellulose-and DEAE-Sephadex A-50, gel filtration on Sephadex G- 100 and preparative Polyacrylamide gel electrophoresis. The molecular weights of the retinolbinding protein-prealbumin complex, prealbumin and retinol-binding protein were found to be 75,000 ...
Sridhara Rao, B, Appaji Rao, N, Cama, HR
openaire   +2 more sources

Mapping of the extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transport

Frontiers in Cell and Developmental Biology, 2023
The distribution of dietary vitamin A/all-trans retinol/ROL throughout the body is critical for maintaining retinoid function in peripheral tissues and for retinoid delivery to the eye in the support of visual function.
Rakesh Radhakrishnan, Matthias Leung, Ashish K. Solanki, Glenn P. Lobo, Glenn P. Lobo, Glenn P. Lobo   +5 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source