Results 31 to 40 of about 15,495 (243)

A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish

Cells, 2020
Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is,
Ashish K. Solanki, Altaf A. Kondkar, Joseph Fogerty, Yanhui Su, Seok-Hyung Kim, Joshua H. Lipschutz, Deepak Nihalani, Brian D. Perkins, Glenn P. Lobo   +8 more
doaj   +1 more source

Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol [PDF]

Journal of the American Society of Nephrology, 1999
Abstract. Transepithelial transport of retinol is linked to retinol-binding protein (RBP), which is taken up and also synthesized in a number of epithelia. By immunocytochemistry of human, rat, and mouse renal proximal tubules, a strong staining in apical endocytic vacuoles, lysosomes, endoplasmic reticulum, Golgi, and basal ...
Christensen, Erik Ilsø, Moskaug, J.Ø., Vorum, Henrik, Jacobsen, Christian, Gundersen, T.E., Nykjær, Anders; id_orcid 0000-0001-6422-6736, Blomhoff, R., Willnow, T.E., Moestrup, Søren Kragh   +8 more
openaire   +3 more sources

Retinoid-binding proteins: similar protein architectures bind similar ligands via completely different ways. [PDF]

PLoS ONE, 2012
BACKGROUND: Retinoids are a class of compounds that are chemically related to vitamin A, which is an essential nutrient that plays a key role in vision, cell growth and differentiation. In vivo, retinoids must bind with specific proteins to perform their
Yu-Ru Zhang, Yu-Qi Zhao, Jing-Fei Huang
doaj   +1 more source

Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions

Journal of Lipid Research, 2021
: Lecithin:retinol acyltransferase and retinol-binding protein enable vitamin A (VA) storage and transport, respectively, maintaining tissue homeostasis of retinoids (VA derivatives).
Maryam Honarbakhsh, Aaron Ericsson, Guo Zhong, Nina Isoherranen, Chengsheng Zhu, Yana Bromberg, Charlene Van Buiten, Kiana Malta, Laurie Joseph, Harini Sampath, Atreju I. Lackey, Judith Storch, Costantino Vetriani, Michael L. Chikindas, Paul Breslin, Loredana Quadro   +15 more
doaj   +1 more source

Retinol Esterification Activity Contributes to Retinol Transport in Stellate Cells.

Cell Structure and Function, 1999
The mechanisms of retinol transport and accumulation in hepatic stellate cells (HSC) remain to be elucidated. Our previous studies suggested that retinol esterification activity, particularly lecithin:retinol acyltransferase (LRAT) activity, in liver retinoid metabolism is important to elucidate the relationship between retinol uptake by HSC and the ...
T, Matsuura, S, Hasumura, S, Nagamori, K, Murakami   +3 more
openaire   +3 more sources

Production of functional human vitamin A transporter/RBP receptor (STRA6) for structure determination. [PDF]

PLoS ONE, 2015
STRA6 is a plasma membrane protein that mediates the transport of vitamin A, or retinol, from plasma retinol binding protein (RBP) into the cell. Mutations in human STRA6 are associated with Matthew-Wood syndrome, which is characterized by severe ...
Conor J Breen, Darren S Martin, Hui Ma, Kate McQuaid, Richard O'Kennedy, John B C Findlay   +5 more
doaj   +1 more source

Serum and intracellular retinol transport in the equine [PDF]

British Journal of Nutrition, 1982
1. Serum and intracellular distribution of retinol was determined in equines maintained on four levels of vitamin A intake.2. The form of retinol transported in serum was determined by gel filtration and chromatography to be a complex of retinol bound to a protein of molecular weight (MW) of approximately 20000, which was in turn complexed probably ...
D. Sklan, Susan Donoghue
openaire   +1 more source

Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure.

Journal of Lipid Research, 1995
Retinol-binding protein (RBP) is the specific blood carrier for the transport of retinol (vitamin A) to target tissues. As the kidney is involved in RBP metabolism, the analysis of RBP species in the serum of patients with chronic renal failure (CRF) was
S. Jaconi, K. Rose, G.J. Hughes, J.H. Saurat, G. Siegenthaler   +4 more
doaj   +1 more source

Effects of acute inflammation on plasma retinol, retinol-binding protein, and its mRNA in the liver and kidneys of vitamin A-sufficient rats

Journal of Lipid Research, 1996
The acute inflammatory response to tissue injury and infection is associated with low concentrations of plasma retinol and its specific transport proteins, retinol-binding protein (RBP) and transthyretin (TTR).
F J Rosales, S J Ritter, R Zolfaghari, J E Smith, A C Ross   +4 more
doaj   +1 more source

Retinol metabolism in rats with low vitamin A status: a compartmental model

Journal of Lipid Research, 1990
A compartmental model was developed to describe the metabolism of vitamin A in rats with low vitamin A status maintained by a low dietary intake of vitamin A (approximately 2 micrograms retinol equivalents/day).
KC Lewis, MH Green, JB Green, LA Zech
doaj   +1 more source