Results 31 to 40 of about 14,996 (210)
A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores.
Journal of Lipid Research, 1985 A linear, first-order, constant-coefficient multicompartmental model is presented which describes the dynamics of [3H]retinol turnover in adult rats with normal plasma retinol concentrations but low liver stores (less than 100 micrograms of retinol ...
M H Green, L Uhl, J B Green
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Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology, EarlyView., 2022 Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr +19 more
wiley +1 more source
Scientific Reports, 2023 This paper expands the current state of knowledge on impact of retinoids on redox status of cytochrome c in cancers. Little is known how the expression of cytochromes may influence the development of cancers.
Jakub Maciej Surmacki, Halina Abramczyk
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CD8+ T cell memory is sustained in mice by hepatic stellate cells
Hepatology, EarlyView., 2022 HSC role in memory CD8+ T cell maintenance. Abstract Background and Aims Long‐lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8+ cytotoxic T cells (MemCD8TCs) is thought to be mediated by IL‐15/IL‐15R heterodimer (15HD)‐expressing myeloid cells.
Yi‐Ting Chen +4 more
wiley +1 more source
Cells, 2020 Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is,
Ashish K. Solanki +8 more
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Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol [PDF]
Journal of the American Society of Nephrology, 1999 Abstract. Transepithelial transport of retinol is linked to retinol-binding protein (RBP), which is taken up and also synthesized in a number of epithelia. By immunocytochemistry of human, rat, and mouse renal proximal tubules, a strong staining in apical endocytic vacuoles, lysosomes, endoplasmic reticulum, Golgi, and basal ...
Christensen, Erik Ilsø +8 more
openaire +3 more sources
Retinol Esterification Activity Contributes to Retinol Transport in Stellate Cells.
Cell Structure and Function, 1999 The mechanisms of retinol transport and accumulation in hepatic stellate cells (HSC) remain to be elucidated. Our previous studies suggested that retinol esterification activity, particularly lecithin:retinol acyltransferase (LRAT) activity, in liver retinoid metabolism is important to elucidate the relationship between retinol uptake by HSC and the ...
T, Matsuura +3 more
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Retinoid-binding proteins: similar protein architectures bind similar ligands via completely different ways. [PDF]
PLoS ONE, 2012 BACKGROUND: Retinoids are a class of compounds that are chemically related to vitamin A, which is an essential nutrient that plays a key role in vision, cell growth and differentiation. In vivo, retinoids must bind with specific proteins to perform their
Yu-Ru Zhang, Yu-Qi Zhao, Jing-Fei Huang
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Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions
Journal of Lipid Research, 2021 : Lecithin:retinol acyltransferase and retinol-binding protein enable vitamin A (VA) storage and transport, respectively, maintaining tissue homeostasis of retinoids (VA derivatives).
Maryam Honarbakhsh +15 more
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eLife, 2014 During inflammation, serum amyloid A proteins transport retinol to infected tissues.
Stephanie C Ganal, Andrew J MacPherson
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