Results 41 to 50 of about 15,860 (203)

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Retinol and retinyl esters in parenchymal and nonparenchymal rat liver cell fractions after long-term administration of ethanol.

Journal of Lipid Research, 1985
Chronic ethanol consumption reduces the liver retinoid store in man and rat. We have studied the effect of ethanol on some aspects of retinoid metabolism in parenchymal and nonparenchymal liver cells.
M Rasmussen, R Blomhoff, P Helgerud, L A Solberg, T Berg, K R Norum   +5 more
doaj   +1 more source

Expression Profiles of Cellular Retinol-binding Protein, Type II (CRBP II) in Erlang Mountainous Chickens [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
Cellular retinol-binding protein II (CRBP II) belongs to the family of cellular retinol-binding proteins and plays a major role in absorption, transport, and metabolism of vitamin A.
H. D. Yin, K. Tian, D. Y. Li, E. R. Gilbert, L. H. Xiao, S. Y. Chen, Y. Wang, Y. P. Liu, X. L. Zhao, Q. Zhu   +9 more
doaj   +1 more source

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

Advanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao, Jing Gao, Xiaohui Su, Xiangying Kong, Xiaolu Wei, Tunan Ding, Tiantian Guo, Shuangrong Gao, Yanyan Zhou, Junyi Zhou, Haiyu Zhao   +10 more
wiley   +1 more source

Transcriptome shifts triggered by vitamin A and SCD genotype interaction in Duroc pigs

BMC Genomics, 2022
Background The composition of intramuscular fat depends on genetic and environmental factors, including the diet. In pigs, we identified a haplotype of three SNP mutations in the stearoyl-coA desaturase (SCD) gene promoter associated with higher content ...
Emma Solé, Rayner González-Prendes, Yelyzaveta Oliinychenko, Marc Tor, Roger Ros-Freixedes, Joan Estany, Ramona N. Pena   +6 more
doaj   +1 more source

A Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation

American Journal of Hematology, EarlyView.
ABSTRACT Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part ...
Marilou Tetard, Tianjian Lin, Nana A. Peterson, Rebekah C. Gullberg, Yann Le Guen, Jasmine Moshiri, John G. Doench, Elizabeth S. Egan   +7 more
wiley   +1 more source

Reduction of Intestinal Redox Potential by Coated Ferulic Acid Accelerates Microbial Restoration and Restricts Enterotoxigenic Escherichia coli Colonization in Weaned Piglets

Animal Research and One Health, EarlyView.
Schematic illustration showing the distinct microbe–host crosstalk patterns shaped by intestinal redox potential. The orange‐blue gradient indicated the redox potential transition from a low to a high potential microenvironment. Under low redox potential, Lactobacillus, Ligilactobacillus, Lachnospira, Roseburia, and Lachnoclostridium promoted ...
Ni Feng, Xin Guo, Changsong Fu, Weiyun Zhu, Yong Su   +4 more
wiley   +1 more source

Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells

Journal of Lipid Research, 2007
The purpose of this study was to compare the mechanisms of intestinal retinol (ROL) and carotenoid transport. When differentiated Caco-2 cells were incubated with ROL for varying times, cellular ROL plateaued within 2 h, whereas retinyl ester (RE ...
Alexandrine During, Earl H. Harrison
doaj   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

A phenomap of TTR amyloidosis to aid diagnostic screening

ESC Heart Failure, Volume 12, Issue 2, Page 1113-1118, April 2025.
Abstract Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in clinical practice.
Alexios S. Antonopoulos, Theodoros Tsampras, George Lazaros, Konstantinos Tsioufis, Charalambos Vlachopoulos   +4 more
wiley   +1 more source